@article{Bailly2015,
abstract = {OBJECTIF
L’objectif de l’\'{e}tude est d’\'{e}valuer l’utilisation du logiciel FreeSurfer pour l’analyse de la volum\'{e}trie IRM et de l’hypom\'{e}tabolisme glucidique en TEP temporale interne dans les troubles cognitifs l\'{e}gers (MCI) et la maladie d’Alzheimer (MA). 

PATIENTS
Vingt et un sujets (7 MA, 6 MCI, 8 t\'{e}moins) ont \'{e}t\'{e} inclus. Une IRM et une TEP au 18F-FDG c\'{e}r\'{e}brales (activit\'{e} moyenne : 185 MBq) ont \'{e}t\'{e} r\'{e}alis\'{e}es. Les images IRM pond\'{e}r\'{e}es en T1 ont \'{e}t\'{e} segment\'{e}es automatiquement \`{a} l’aide du logiciel gratuit FreeSurfer (http://surfer.nmr.mgh.harvard.edu/). Les images TEP ont \'{e}t\'{e} recal\'{e}es \`{a} l’IRM. Pour chaque r\'{e}gion d’int\'{e}r\^{e}t (hippocampe et amygdale), le volume c\'{e}r\'{e}bral normalis\'{e} par rapport au volume c\'{e}r\'{e}bral total, ainsi que l’intensit\'{e} maximale de fixation du 18F-FDG normalis\'{e}e par rapport \`{a} la fixation c\'{e}r\'{e}belleuse ont \'{e}t\'{e} analys\'{e}s. 

R\'{E}SULTATS
Le volume hippocampique normalis\'{e} moyen (±d\'{e}viation standard [DS]) est statistiquement diff\'{e}rent dans les trois groupes : 0,60±0,07 \%, 0,64±0,11 \% et 0,74±0,07 \%, respectivement, pour les sujets MA, MCI et t\'{e}moins (p<0,05). De m\^{e}me, il existe un hypom\'{e}tabolisme glucidique significatif chez les sujets MCI et MA, avec des ratios d’intensit\'{e} de fixation du 18F-FDG normalis\'{e}s (±DS) de 0,83±0,10, 0,72±0,11 et 0,69±0,06 pour les groupes t\'{e}moins, MCI et MA, respectivement (p<0,05). 

CONCLUSION
Cette \'{e}tude, utilisant FreeSurfer, v\'{e}rifie la r\'{e}duction significative du volume hippocampique chez les MCI et les MA, associ\'{e}e \`{a} un hypom\'{e}tabolisme glucidique, et sugg\`{e}re son utilisation pour des \'{e}tudes de volum\'{e}trie et de quantification TEP automatiques \`{a} grande \'{e}chelle. 

OBJECTIVE
FreeSurfer is an automated structural MRI image processing software used in Alzheimer's disease (AD). The objective of our study was to assess the feasibility and utility of FreeSurfer to study both glucose metabolism by 18F-FDG and atrophy by MRI in patients with AD and mild cognitive impairment (MCI). 

METHODS
Twenty-one subjects (7 patients with AD, 6 patients with amnestic MCI, and 8 healthy controls [HC]) were included. MRI and PET images using 18F-FDG (mean injected dose: 185 MBq) were acquired. MRI images were analyzed using FreeSurfer to generate regional volumes, normalized by total brain volume without ventricles. PET images were registered to the T1-weighted MRI images and medial temporal uptake normalized by cerebellum uptake was measured. 

RESULTS
Mean normalized hippocampal volume was significantly different between the three groups: 0.60\% of brain total volume for patients with AD, 0.64\% for MCI patients and 0.74\% for controls (P<0.05). 18F-FDG uptake was also lower in the hippocampus of patients with AD or MCI than in controls: it was 0.69 for patients with AD, 0.72 for MCI patients and 0.83 for controls (P<0.05). 

CONCLUSION
We found that analysis of imaging data with FreeSurfer revealed low 18F-FDG uptake and atrophy in the hippocampus of patients with AD. Our study demonstrates that this software can be used to analyze and quantify both 18F-FDG and MRI data in the context of dementia.},
author = {Bailly, M. and Destrieux, Christophe and Hommet, Caroline and Mondon, Karl and Beaufils, Emilie and Cottier, Jean-Philippe and Camus, Vincent and Guilloteau, Denis and Santiago-Ribeiro, M. J.},
doi = {10.1016/j.mednuc.2014.12.010},
issn = {09281258},
journal = {M\'{e}decine Nucl\'{e}aire},
keywords = {18F-FDG,Alzheimer,Alzheimer's disease,Atrophie c\'{e}r\'{e}brale,FreeSurfer,IRM,MCI,MRI atrophy,Medial temporal,PET,TEP,Temporal interne},
month = jan,
title = {{\'{E}valuation de la faisabilit\'{e} de l’analyse quantitative combin\'{e}e de la TEP 18F-FDG et de l’IRM dans la maladie d’Alzheimer avec FreeSurfer. Exemple de l’hippocampe}},
year = {2015}
}

{"_id":"9hrdgdXa25zeeGFQD","bibbaseid":"bailly-destrieux-hommet-mondon-beaufils-cottier-camus-guilloteau-etal-valuationdelafaisabilitdelanalysequantitativecombinedelatep18ffdgetdelirmdanslamaladiedalzheimeravecfreesurferexempledelhippocampe-2015","downloads":0,"creationDate":"2015-12-07T17:51:29.425Z","title":"Évaluation de la faisabilité de l’analyse quantitative combinée de la TEP 18F-FDG et de l’IRM dans la maladie d’Alzheimer avec FreeSurfer. Exemple de l’hippocampe","author_short":["Bailly, M.","Destrieux, C.","Hommet, C.","Mondon, K.","Beaufils, E.","Cottier, J.","Camus, V.","Guilloteau, D.","Santiago-Ribeiro, M. J."],"year":2015,"bibtype":"article","biburl":"https://docs.google.com/uc?authuser=0&id=0B2xmYAQCJf7AaGJqTVhlWVNoMjQ&export=download","bibdata":{"bibtype":"article","type":"article","abstract":"OBJECTIF L’objectif de l’étude est d’évaluer l’utilisation du logiciel FreeSurfer pour l’analyse de la volumétrie IRM et de l’hypométabolisme glucidique en TEP temporale interne dans les troubles cognitifs légers (MCI) et la maladie d’Alzheimer (MA). PATIENTS Vingt et un sujets (7 MA, 6 MCI, 8 témoins) ont été inclus. Une IRM et une TEP au 18F-FDG cérébrales (activité moyenne : 185 MBq) ont été réalisées. Les images IRM pondérées en T1 ont été segmentées automatiquement à l’aide du logiciel gratuit FreeSurfer (http://surfer.nmr.mgh.harvard.edu/). Les images TEP ont été recalées à l’IRM. Pour chaque région d’intér\\^et (hippocampe et amygdale), le volume cérébral normalisé par rapport au volume cérébral total, ainsi que l’intensité maximale de fixation du 18F-FDG normalisée par rapport à la fixation cérébelleuse ont été analysés. RÉSULTATS Le volume hippocampique normalisé moyen (±déviation standard [DS]) est statistiquement différent dans les trois groupes : 0,60±0,07 %, 0,64±0,11 % et 0,74±0,07 %, respectivement, pour les sujets MA, MCI et témoins (p<0,05). De m\\^eme, il existe un hypométabolisme glucidique significatif chez les sujets MCI et MA, avec des ratios d’intensité de fixation du 18F-FDG normalisés (±DS) de 0,83±0,10, 0,72±0,11 et 0,69±0,06 pour les groupes témoins, MCI et MA, respectivement (p<0,05). CONCLUSION Cette étude, utilisant FreeSurfer, vérifie la réduction significative du volume hippocampique chez les MCI et les MA, associée à un hypométabolisme glucidique, et suggère son utilisation pour des études de volumétrie et de quantification TEP automatiques à grande échelle. OBJECTIVE FreeSurfer is an automated structural MRI image processing software used in Alzheimer's disease (AD). The objective of our study was to assess the feasibility and utility of FreeSurfer to study both glucose metabolism by 18F-FDG and atrophy by MRI in patients with AD and mild cognitive impairment (MCI). METHODS Twenty-one subjects (7 patients with AD, 6 patients with amnestic MCI, and 8 healthy controls [HC]) were included. MRI and PET images using 18F-FDG (mean injected dose: 185 MBq) were acquired. MRI images were analyzed using FreeSurfer to generate regional volumes, normalized by total brain volume without ventricles. PET images were registered to the T1-weighted MRI images and medial temporal uptake normalized by cerebellum uptake was measured. RESULTS Mean normalized hippocampal volume was significantly different between the three groups: 0.60% of brain total volume for patients with AD, 0.64% for MCI patients and 0.74% for controls (P<0.05). 18F-FDG uptake was also lower in the hippocampus of patients with AD or MCI than in controls: it was 0.69 for patients with AD, 0.72 for MCI patients and 0.83 for controls (P<0.05). CONCLUSION We found that analysis of imaging data with FreeSurfer revealed low 18F-FDG uptake and atrophy in the hippocampus of patients with AD. Our study demonstrates that this software can be used to analyze and quantify both 18F-FDG and MRI data in the context of dementia.","author":[{"propositions":[],"lastnames":["Bailly"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Destrieux"],"firstnames":["Christophe"],"suffixes":[]},{"propositions":[],"lastnames":["Hommet"],"firstnames":["Caroline"],"suffixes":[]},{"propositions":[],"lastnames":["Mondon"],"firstnames":["Karl"],"suffixes":[]},{"propositions":[],"lastnames":["Beaufils"],"firstnames":["Emilie"],"suffixes":[]},{"propositions":[],"lastnames":["Cottier"],"firstnames":["Jean-Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Camus"],"firstnames":["Vincent"],"suffixes":[]},{"propositions":[],"lastnames":["Guilloteau"],"firstnames":["Denis"],"suffixes":[]},{"propositions":[],"lastnames":["Santiago-Ribeiro"],"firstnames":["M.","J."],"suffixes":[]}],"doi":"10.1016/j.mednuc.2014.12.010","issn":"09281258","journal":"Médecine Nucléaire","keywords":"18F-FDG,Alzheimer,Alzheimer's disease,Atrophie cérébrale,FreeSurfer,IRM,MCI,MRI atrophy,Medial temporal,PET,TEP,Temporal interne","month":"January","title":"Évaluation de la faisabilité de l’analyse quantitative combinée de la TEP 18F-FDG et de l’IRM dans la maladie d’Alzheimer avec FreeSurfer. Exemple de l’hippocampe","year":"2015","bibtex":"@article{Bailly2015,\nabstract = {OBJECTIF\nL’objectif de l’\\'{e}tude est d’\\'{e}valuer l’utilisation du logiciel FreeSurfer pour l’analyse de la volum\\'{e}trie IRM et de l’hypom\\'{e}tabolisme glucidique en TEP temporale interne dans les troubles cognitifs l\\'{e}gers (MCI) et la maladie d’Alzheimer (MA). \n\nPATIENTS\nVingt et un sujets (7 MA, 6 MCI, 8 t\\'{e}moins) ont \\'{e}t\\'{e} inclus. Une IRM et une TEP au 18F-FDG c\\'{e}r\\'{e}brales (activit\\'{e} moyenne : 185 MBq) ont \\'{e}t\\'{e} r\\'{e}alis\\'{e}es. Les images IRM pond\\'{e}r\\'{e}es en T1 ont \\'{e}t\\'{e} segment\\'{e}es automatiquement \\`{a} l’aide du logiciel gratuit FreeSurfer (http://surfer.nmr.mgh.harvard.edu/). Les images TEP ont \\'{e}t\\'{e} recal\\'{e}es \\`{a} l’IRM. Pour chaque r\\'{e}gion d’int\\'{e}r\\^{e}t (hippocampe et amygdale), le volume c\\'{e}r\\'{e}bral normalis\\'{e} par rapport au volume c\\'{e}r\\'{e}bral total, ainsi que l’intensit\\'{e} maximale de fixation du 18F-FDG normalis\\'{e}e par rapport \\`{a} la fixation c\\'{e}r\\'{e}belleuse ont \\'{e}t\\'{e} analys\\'{e}s. \n\nR\\'{E}SULTATS\nLe volume hippocampique normalis\\'{e} moyen (±d\\'{e}viation standard [DS]) est statistiquement diff\\'{e}rent dans les trois groupes : 0,60±0,07 \\%, 0,64±0,11 \\% et 0,74±0,07 \\%, respectivement, pour les sujets MA, MCI et t\\'{e}moins (p<0,05). De m\\^{e}me, il existe un hypom\\'{e}tabolisme glucidique significatif chez les sujets MCI et MA, avec des ratios d’intensit\\'{e} de fixation du 18F-FDG normalis\\'{e}s (±DS) de 0,83±0,10, 0,72±0,11 et 0,69±0,06 pour les groupes t\\'{e}moins, MCI et MA, respectivement (p<0,05). \n\nCONCLUSION\nCette \\'{e}tude, utilisant FreeSurfer, v\\'{e}rifie la r\\'{e}duction significative du volume hippocampique chez les MCI et les MA, associ\\'{e}e \\`{a} un hypom\\'{e}tabolisme glucidique, et sugg\\`{e}re son utilisation pour des \\'{e}tudes de volum\\'{e}trie et de quantification TEP automatiques \\`{a} grande \\'{e}chelle. \n\nOBJECTIVE\nFreeSurfer is an automated structural MRI image processing software used in Alzheimer's disease (AD). The objective of our study was to assess the feasibility and utility of FreeSurfer to study both glucose metabolism by 18F-FDG and atrophy by MRI in patients with AD and mild cognitive impairment (MCI). \n\nMETHODS\nTwenty-one subjects (7 patients with AD, 6 patients with amnestic MCI, and 8 healthy controls [HC]) were included. MRI and PET images using 18F-FDG (mean injected dose: 185 MBq) were acquired. MRI images were analyzed using FreeSurfer to generate regional volumes, normalized by total brain volume without ventricles. PET images were registered to the T1-weighted MRI images and medial temporal uptake normalized by cerebellum uptake was measured. \n\nRESULTS\nMean normalized hippocampal volume was significantly different between the three groups: 0.60\\% of brain total volume for patients with AD, 0.64\\% for MCI patients and 0.74\\% for controls (P<0.05). 18F-FDG uptake was also lower in the hippocampus of patients with AD or MCI than in controls: it was 0.69 for patients with AD, 0.72 for MCI patients and 0.83 for controls (P<0.05). \n\nCONCLUSION\nWe found that analysis of imaging data with FreeSurfer revealed low 18F-FDG uptake and atrophy in the hippocampus of patients with AD. Our study demonstrates that this software can be used to analyze and quantify both 18F-FDG and MRI data in the context of dementia.},\nauthor = {Bailly, M. and Destrieux, Christophe and Hommet, Caroline and Mondon, Karl and Beaufils, Emilie and Cottier, Jean-Philippe and Camus, Vincent and Guilloteau, Denis and Santiago-Ribeiro, M. J.},\ndoi = {10.1016/j.mednuc.2014.12.010},\nissn = {09281258},\njournal = {M\\'{e}decine Nucl\\'{e}aire},\nkeywords = {18F-FDG,Alzheimer,Alzheimer's disease,Atrophie c\\'{e}r\\'{e}brale,FreeSurfer,IRM,MCI,MRI atrophy,Medial temporal,PET,TEP,Temporal interne},\nmonth = jan,\ntitle = {{\\'{E}valuation de la faisabilit\\'{e} de l’analyse quantitative combin\\'{e}e de la TEP 18F-FDG et de l’IRM dans la maladie d’Alzheimer avec FreeSurfer. Exemple de l’hippocampe}},\nyear = {2015}\n}\n","author_short":["Bailly, M.","Destrieux, C.","Hommet, C.","Mondon, K.","Beaufils, E.","Cottier, J.","Camus, V.","Guilloteau, D.","Santiago-Ribeiro, M. J."],"key":"Bailly2015","id":"Bailly2015","bibbaseid":"bailly-destrieux-hommet-mondon-beaufils-cottier-camus-guilloteau-etal-valuationdelafaisabilitdelanalysequantitativecombinedelatep18ffdgetdelirmdanslamaladiedalzheimeravecfreesurferexempledelhippocampe-2015","role":"author","urls":{},"keyword":["18F-FDG","Alzheimer","Alzheimer's disease","Atrophie cérébrale","FreeSurfer","IRM","MCI","MRI atrophy","Medial temporal","PET","TEP","Temporal interne"],"downloads":0},"search_terms":["valuation","faisabilit","analyse","quantitative","combin","tep","18f","fdg","irm","dans","maladie","alzheimer","avec","freesurfer","exemple","hippocampe","bailly","destrieux","hommet","mondon","beaufils","cottier","camus","guilloteau","santiago-ribeiro"],"keywords":["18f-fdg","alzheimer","alzheimer's disease","atrophie cérébrale","freesurfer","irm","mci","mri atrophy","medial temporal","pet","tep","temporal interne"],"authorIDs":[],"dataSources":["EtjZYJPqwuNhYrhrE"]}