@article{RN6199,
   author = {Bakker, W. J. and van Dijk, T. B. and Parren-van Amelsvoort, M. and Kolbus, A. and Yamamoto, K. and Steinlein, P. and Verhaak, R. G. and Mak, T. W. and Beug, H. and Löwenberg, B. and von Lindern, M.},
   title = {Differential regulation of Foxo3a target genes in erythropoiesis},
   journal = {Mol Cell Biol},
   volume = {27},
   number = {10},
   pages = {3839-3854},
   note = {1098-5549
Bakker, Walbert J
van Dijk, Thamar B
Parren-van Amelsvoort, Martine
Kolbus, Andrea
Yamamoto, Kazuo
Steinlein, Peter
Verhaak, Roel G W
Mak, Tak W
Beug, Hartmut
Löwenberg, Bob
von Lindern, Marieke
Journal Article
Research Support, Non-U.S. Gov't
United States
2007/03/14
Mol Cell Biol. 2007 May;27(10):3839-3854. doi: 10.1128/MCB.01662-06.},
   abstract = {The cooperation of stem cell factor (SCF) and erythropoietin (Epo) is required to induce renewal divisions in erythroid progenitors, whereas differentiation to mature erythrocytes requires the presence of Epo only. Epo and SCF activate common signaling pathways such as the activation of protein kinase B (PKB) and the subsequent phosphorylation and inactivation of Foxo3a. In contrast, only Epo activates Stat5. Both Foxo3a and Stat5 promote erythroid differentiation. To understand the interplay of SCF and Epo in maintaining the balance between renewal and differentiation during erythroid development, we investigated differential Foxo3a target regulation by Epo and SCF. Expression profiling revealed that a subset of Foxo3a targets was not inhibited but was activated by Epo. One of these genes was Cited2. Transcriptional control of Epo/Foxo3a-induced Cited2 was studied and compared with that of the Epo-repressed Foxo3a target Btg1. We show that in response to Epo, the allegedly growth-inhibitory factor Foxo3a associates with the allegedly growth-stimulatory factor Stat5 in the nucleus, which is required for Epo-induced Cited2 expression. In contrast, Btg1 expression is controlled by the cooperation of Foxo3a with cyclic AMP- and Jun kinase-dependent Creb family members. Thus, Foxo3a not only is an effector of PKB but also integrates distinct signals to regulate gene expression in erythropoiesis.},
   keywords = {Animals
Base Sequence
Cell Differentiation/physiology
Cells, Cultured
Cluster Analysis
Cyclic AMP Response Element-Binding Protein/genetics/metabolism
DNA-Binding Proteins/genetics/metabolism
Erythropoiesis/*physiology
Erythropoietin/*metabolism
Forkhead Box Protein O3
Forkhead Transcription Factors/genetics/*metabolism
Gene Expression Profiling
*Gene Expression Regulation
Humans
Mice
Molecular Sequence Data
Neoplasm Proteins/genetics/metabolism
Oligonucleotide Array Sequence Analysis
Phosphatidylinositol 3-Kinases/metabolism
Repressor Proteins/genetics/metabolism
STAT5 Transcription Factor/genetics/metabolism
Sequence Alignment
Signal Transduction/physiology
Stem Cell Factor/*metabolism
Trans-Activators/genetics/metabolism},
   ISSN = {0270-7306 (Print)
0270-7306},
   DOI = {10.1128/mcb.01662-06},
   year = {2007},
   type = {Journal Article}
}

{"_id":"dWLQmxorMyoT6B6uP","bibbaseid":"bakker-vandijk-parrenvanamelsvoort-kolbus-yamamoto-steinlein-verhaak-mak-etal-differentialregulationoffoxo3atargetgenesinerythropoiesis-2007","author_short":["Bakker, W. J.","van Dijk, T. B.","Parren-van Amelsvoort, M.","Kolbus, A.","Yamamoto, K.","Steinlein, P.","Verhaak, R. G.","Mak, T. W.","Beug, H.","Löwenberg, B.","von Lindern, M."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Bakker"],"firstnames":["W.","J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Dijk"],"firstnames":["T.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Parren-van","Amelsvoort"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Kolbus"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Yamamoto"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Steinlein"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Verhaak"],"firstnames":["R.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Mak"],"firstnames":["T.","W."],"suffixes":[]},{"propositions":[],"lastnames":["Beug"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Löwenberg"],"firstnames":["B."],"suffixes":[]},{"propositions":["von"],"lastnames":["Lindern"],"firstnames":["M."],"suffixes":[]}],"title":"Differential regulation of Foxo3a target genes in erythropoiesis","journal":"Mol Cell Biol","volume":"27","number":"10","pages":"3839-3854","note":"1098-5549 Bakker, Walbert J van Dijk, Thamar B Parren-van Amelsvoort, Martine Kolbus, Andrea Yamamoto, Kazuo Steinlein, Peter Verhaak, Roel G W Mak, Tak W Beug, Hartmut Löwenberg, Bob von Lindern, Marieke Journal Article Research Support, Non-U.S. Gov't United States 2007/03/14 Mol Cell Biol. 2007 May;27(10):3839-3854. doi: 10.1128/MCB.01662-06.","abstract":"The cooperation of stem cell factor (SCF) and erythropoietin (Epo) is required to induce renewal divisions in erythroid progenitors, whereas differentiation to mature erythrocytes requires the presence of Epo only. Epo and SCF activate common signaling pathways such as the activation of protein kinase B (PKB) and the subsequent phosphorylation and inactivation of Foxo3a. In contrast, only Epo activates Stat5. Both Foxo3a and Stat5 promote erythroid differentiation. To understand the interplay of SCF and Epo in maintaining the balance between renewal and differentiation during erythroid development, we investigated differential Foxo3a target regulation by Epo and SCF. Expression profiling revealed that a subset of Foxo3a targets was not inhibited but was activated by Epo. One of these genes was Cited2. Transcriptional control of Epo/Foxo3a-induced Cited2 was studied and compared with that of the Epo-repressed Foxo3a target Btg1. We show that in response to Epo, the allegedly growth-inhibitory factor Foxo3a associates with the allegedly growth-stimulatory factor Stat5 in the nucleus, which is required for Epo-induced Cited2 expression. In contrast, Btg1 expression is controlled by the cooperation of Foxo3a with cyclic AMP- and Jun kinase-dependent Creb family members. Thus, Foxo3a not only is an effector of PKB but also integrates distinct signals to regulate gene expression in erythropoiesis.","keywords":"Animals Base Sequence Cell Differentiation/physiology Cells, Cultured Cluster Analysis Cyclic AMP Response Element-Binding Protein/genetics/metabolism DNA-Binding Proteins/genetics/metabolism Erythropoiesis/*physiology Erythropoietin/*metabolism Forkhead Box Protein O3 Forkhead Transcription Factors/genetics/*metabolism Gene Expression Profiling *Gene Expression Regulation Humans Mice Molecular Sequence Data Neoplasm Proteins/genetics/metabolism Oligonucleotide Array Sequence Analysis Phosphatidylinositol 3-Kinases/metabolism Repressor Proteins/genetics/metabolism STAT5 Transcription Factor/genetics/metabolism Sequence Alignment Signal Transduction/physiology Stem Cell Factor/*metabolism Trans-Activators/genetics/metabolism","issn":"0270-7306 (Print) 0270-7306","doi":"10.1128/mcb.01662-06","year":"2007","bibtex":"@article{RN6199,\n author = {Bakker, W. J. and van Dijk, T. B. and Parren-van Amelsvoort, M. and Kolbus, A. and Yamamoto, K. and Steinlein, P. and Verhaak, R. G. and Mak, T. W. and Beug, H. and Löwenberg, B. and von Lindern, M.},\n title = {Differential regulation of Foxo3a target genes in erythropoiesis},\n journal = {Mol Cell Biol},\n volume = {27},\n number = {10},\n pages = {3839-3854},\n note = {1098-5549\nBakker, Walbert J\nvan Dijk, Thamar B\nParren-van Amelsvoort, Martine\nKolbus, Andrea\nYamamoto, Kazuo\nSteinlein, Peter\nVerhaak, Roel G W\nMak, Tak W\nBeug, Hartmut\nLöwenberg, Bob\nvon Lindern, Marieke\nJournal Article\nResearch Support, Non-U.S. Gov't\nUnited States\n2007/03/14\nMol Cell Biol. 2007 May;27(10):3839-3854. doi: 10.1128/MCB.01662-06.},\n abstract = {The cooperation of stem cell factor (SCF) and erythropoietin (Epo) is required to induce renewal divisions in erythroid progenitors, whereas differentiation to mature erythrocytes requires the presence of Epo only. Epo and SCF activate common signaling pathways such as the activation of protein kinase B (PKB) and the subsequent phosphorylation and inactivation of Foxo3a. In contrast, only Epo activates Stat5. Both Foxo3a and Stat5 promote erythroid differentiation. To understand the interplay of SCF and Epo in maintaining the balance between renewal and differentiation during erythroid development, we investigated differential Foxo3a target regulation by Epo and SCF. Expression profiling revealed that a subset of Foxo3a targets was not inhibited but was activated by Epo. One of these genes was Cited2. Transcriptional control of Epo/Foxo3a-induced Cited2 was studied and compared with that of the Epo-repressed Foxo3a target Btg1. We show that in response to Epo, the allegedly growth-inhibitory factor Foxo3a associates with the allegedly growth-stimulatory factor Stat5 in the nucleus, which is required for Epo-induced Cited2 expression. In contrast, Btg1 expression is controlled by the cooperation of Foxo3a with cyclic AMP- and Jun kinase-dependent Creb family members. Thus, Foxo3a not only is an effector of PKB but also integrates distinct signals to regulate gene expression in erythropoiesis.},\n keywords = {Animals\nBase Sequence\nCell Differentiation/physiology\nCells, Cultured\nCluster Analysis\nCyclic AMP Response Element-Binding Protein/genetics/metabolism\nDNA-Binding Proteins/genetics/metabolism\nErythropoiesis/*physiology\nErythropoietin/*metabolism\nForkhead Box Protein O3\nForkhead Transcription Factors/genetics/*metabolism\nGene Expression Profiling\n*Gene Expression Regulation\nHumans\nMice\nMolecular Sequence Data\nNeoplasm Proteins/genetics/metabolism\nOligonucleotide Array Sequence Analysis\nPhosphatidylinositol 3-Kinases/metabolism\nRepressor Proteins/genetics/metabolism\nSTAT5 Transcription Factor/genetics/metabolism\nSequence Alignment\nSignal Transduction/physiology\nStem Cell Factor/*metabolism\nTrans-Activators/genetics/metabolism},\n ISSN = {0270-7306 (Print)\n0270-7306},\n DOI = {10.1128/mcb.01662-06},\n year = {2007},\n type = {Journal Article}\n}\n\n","author_short":["Bakker, W. 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