@article{ WOS:001227832200001,
Author = {Balikci, Esra and Marques, Anne-Sophie M. C. and Bauer, Ludwig G. and
   Seupel, Raina and Bennett, James and Raux, Brigitt and Buchan, Karly and
   Simelis, Klemensas and Singh, Usha and Rogers, Catherine and Ward,
   Jennifer and Cheng, Carol and Szommer, Tamas and Schutzenhofer, Kira and
   Elkins, Jonathan M. and Sloman, David L. and Ahel, Ivan and Fedorov,
   Oleg and Brennan, Paul E. and Huber, Kilian V. M.},
Title = {Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors
   Leads to Discovery of a Dual NUDT5/14 Antagonist},
Journal = {JOURNAL OF MEDICINAL CHEMISTRY},
Year = {2024},
Volume = {67},
Number = {9},
Pages = {7245-7259},
Month = {APR 18},
DOI = {10.1021/acs.jmedchem.4c00072},
ISSN = {0022-2623},
EISSN = {1520-4804},
ResearcherID-Numbers = {Huber, Kilian/L-6921-2015
   RAUX, BRIGITT/H-7391-2018
   Fedorov, Oleg/B-6412-2014
   },
ORCID-Numbers = {Bauer, Ludwig G./0000-0002-2235-3945
   Szommer, Tamas/0000-0002-3811-4068
   Marques, Anne-Sophie M. C./0009-0005-5726-508X
   Balikci, Esra/0009-0000-9160-5790
   Bennett, James/0000-0003-1396-8400
   Simelis, Klemensas/0000-0001-7578-4370},
Unique-ID = {WOS:001227832200001},
}

{"_id":"eMxY5byAhbjwwbTJA","bibbaseid":"balikci-marques-bauer-seupel-bennett-raux-buchan-simelis-etal-unexpectednoncovalentofftargetactivityofclinicalbtkinhibitorsleadstodiscoveryofadualnudt514antagonist-2024","author_short":["Balikci, E.","Marques, A. M. C.","Bauer, L. G.","Seupel, R.","Bennett, J.","Raux, B.","Buchan, K.","Simelis, K.","Singh, U.","Rogers, C.","Ward, J.","Cheng, C.","Szommer, T.","Schutzenhofer, K.","Elkins, J. M.","Sloman, D. L.","Ahel, I.","Fedorov, O.","Brennan, P. E.","Huber, K. V. M."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Balikci"],"firstnames":["Esra"],"suffixes":[]},{"propositions":[],"lastnames":["Marques"],"firstnames":["Anne-Sophie","M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Bauer"],"firstnames":["Ludwig","G."],"suffixes":[]},{"propositions":[],"lastnames":["Seupel"],"firstnames":["Raina"],"suffixes":[]},{"propositions":[],"lastnames":["Bennett"],"firstnames":["James"],"suffixes":[]},{"propositions":[],"lastnames":["Raux"],"firstnames":["Brigitt"],"suffixes":[]},{"propositions":[],"lastnames":["Buchan"],"firstnames":["Karly"],"suffixes":[]},{"propositions":[],"lastnames":["Simelis"],"firstnames":["Klemensas"],"suffixes":[]},{"propositions":[],"lastnames":["Singh"],"firstnames":["Usha"],"suffixes":[]},{"propositions":[],"lastnames":["Rogers"],"firstnames":["Catherine"],"suffixes":[]},{"propositions":[],"lastnames":["Ward"],"firstnames":["Jennifer"],"suffixes":[]},{"propositions":[],"lastnames":["Cheng"],"firstnames":["Carol"],"suffixes":[]},{"propositions":[],"lastnames":["Szommer"],"firstnames":["Tamas"],"suffixes":[]},{"propositions":[],"lastnames":["Schutzenhofer"],"firstnames":["Kira"],"suffixes":[]},{"propositions":[],"lastnames":["Elkins"],"firstnames":["Jonathan","M."],"suffixes":[]},{"propositions":[],"lastnames":["Sloman"],"firstnames":["David","L."],"suffixes":[]},{"propositions":[],"lastnames":["Ahel"],"firstnames":["Ivan"],"suffixes":[]},{"propositions":[],"lastnames":["Fedorov"],"firstnames":["Oleg"],"suffixes":[]},{"propositions":[],"lastnames":["Brennan"],"firstnames":["Paul","E."],"suffixes":[]},{"propositions":[],"lastnames":["Huber"],"firstnames":["Kilian","V.","M."],"suffixes":[]}],"title":"Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist","journal":"JOURNAL OF MEDICINAL CHEMISTRY","year":"2024","volume":"67","number":"9","pages":"7245-7259","month":"APR 18","doi":"10.1021/acs.jmedchem.4c00072","issn":"0022-2623","eissn":"1520-4804","researcherid-numbers":"Huber, Kilian/L-6921-2015 RAUX, BRIGITT/H-7391-2018 Fedorov, Oleg/B-6412-2014 ","orcid-numbers":"Bauer, Ludwig G./0000-0002-2235-3945 Szommer, Tamas/0000-0002-3811-4068 Marques, Anne-Sophie M. C./0009-0005-5726-508X Balikci, Esra/0009-0000-9160-5790 Bennett, James/0000-0003-1396-8400 Simelis, Klemensas/0000-0001-7578-4370","unique-id":"WOS:001227832200001","bibtex":"@article{ WOS:001227832200001,\nAuthor = {Balikci, Esra and Marques, Anne-Sophie M. C. and Bauer, Ludwig G. and\n Seupel, Raina and Bennett, James and Raux, Brigitt and Buchan, Karly and\n Simelis, Klemensas and Singh, Usha and Rogers, Catherine and Ward,\n Jennifer and Cheng, Carol and Szommer, Tamas and Schutzenhofer, Kira and\n Elkins, Jonathan M. and Sloman, David L. and Ahel, Ivan and Fedorov,\n Oleg and Brennan, Paul E. and Huber, Kilian V. M.},\nTitle = {Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors\n Leads to Discovery of a Dual NUDT5/14 Antagonist},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2024},\nVolume = {67},\nNumber = {9},\nPages = {7245-7259},\nMonth = {APR 18},\nDOI = {10.1021/acs.jmedchem.4c00072},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Huber, Kilian/L-6921-2015\n RAUX, BRIGITT/H-7391-2018\n Fedorov, Oleg/B-6412-2014\n },\nORCID-Numbers = {Bauer, Ludwig G./0000-0002-2235-3945\n Szommer, Tamas/0000-0002-3811-4068\n Marques, Anne-Sophie M. C./0009-0005-5726-508X\n Balikci, Esra/0009-0000-9160-5790\n Bennett, James/0000-0003-1396-8400\n Simelis, Klemensas/0000-0001-7578-4370},\nUnique-ID = {WOS:001227832200001},\n}\n\n","author_short":["Balikci, E.","Marques, A. M. C.","Bauer, L. G.","Seupel, R.","Bennett, J.","Raux, B.","Buchan, K.","Simelis, K.","Singh, U.","Rogers, C.","Ward, J.","Cheng, C.","Szommer, T.","Schutzenhofer, K.","Elkins, J. M.","Sloman, D. L.","Ahel, I.","Fedorov, O.","Brennan, P. E.","Huber, K. V. M."],"key":"WOS:001227832200001","id":"WOS:001227832200001","bibbaseid":"balikci-marques-bauer-seupel-bennett-raux-buchan-simelis-etal-unexpectednoncovalentofftargetactivityofclinicalbtkinhibitorsleadstodiscoveryofadualnudt514antagonist-2024","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/HECPruWhe6gDg5ZWN","dataSources":["qhzgQBKWKwmm6xY73","NBNKNR2KcNSWDgFcf","4mccB2G6uYe3AhfDs"],"keywords":[],"search_terms":["unexpected","noncovalent","target","activity","clinical","btk","inhibitors","leads","discovery","dual","nudt5","antagonist","balikci","marques","bauer","seupel","bennett","raux","buchan","simelis","singh","rogers","ward","cheng","szommer","schutzenhofer","elkins","sloman","ahel","fedorov","brennan","huber"],"title":"Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist","year":2024}