Evidence for a Direct Link between Glutathione Biosynthesis and Stress Defense Gene Expression in Arabidopsis[W]. Ball, L., Accotto, G., Bechtold, U., Creissen, G., Funck, D., Jimenez, A., Kular, B., Leyland, N., Mejia-Carranza, J., Reynolds, H., Karpinski, S., & Mullineaux, P. M. The Plant Cell, 16(9):2448–2462, September, 2004. ![Evidence for a Direct Link between Glutathione Biosynthesis and Stress Defense Gene Expression in Arabidopsis[W] [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The mutant regulator of APX2 1-1 (rax1-1) was identified in Arabidopsis thaliana that constitutively expressed normally photooxidative stress-inducible ASCORBATE PEROXIDASE2 (APX2) and had ≥50% lowered foliar glutathione levels. Mapping revealed that rax1-1 is an allele of γ-GLUTAMYLCYSTEINE SYNTHETASE 1 (GSH1), which encodes chloroplastic γ-glutamylcysteine synthetase, the controlling step of glutathione biosynthesis. By comparison of rax1-1 with the GSH1 mutant cadmium hypersensitive 2, the expression of 32 stress-responsive genes was shown to be responsive to changed glutathione metabolism. Under photo-oxidative stress conditions, the expression of a wider set of defense-related genes was altered in the mutants. In wild-type plants, glutathione metabolism may play a key role in determining the degree of expression of defense genes controlled by several signaling pathways both before and during stress. This control may reflect the physiological state of the plant at the time of the onset of an environmental challenge and suggests that changes in glutathione metabolism may be one means of integrating the function of several signaling pathways.
@article{ball_evidence_2004,
title = {Evidence for a {Direct} {Link} between {Glutathione} {Biosynthesis} and {Stress} {Defense} {Gene} {Expression} in {Arabidopsis}[{W}]},
volume = {16},
issn = {1040-4651},
url = {https://doi.org/10.1105/tpc.104.022608},
doi = {10/dnj446},
abstract = {The mutant regulator of APX2 1-1 (rax1-1) was identified in Arabidopsis thaliana that constitutively expressed normally photooxidative stress-inducible ASCORBATE PEROXIDASE2 (APX2) and had ≥50\% lowered foliar glutathione levels. Mapping revealed that rax1-1 is an allele of γ-GLUTAMYLCYSTEINE SYNTHETASE 1 (GSH1), which encodes chloroplastic γ-glutamylcysteine synthetase, the controlling step of glutathione biosynthesis. By comparison of rax1-1 with the GSH1 mutant cadmium hypersensitive 2, the expression of 32 stress-responsive genes was shown to be responsive to changed glutathione metabolism. Under photo-oxidative stress conditions, the expression of a wider set of defense-related genes was altered in the mutants. In wild-type plants, glutathione metabolism may play a key role in determining the degree of expression of defense genes controlled by several signaling pathways both before and during stress. This control may reflect the physiological state of the plant at the time of the onset of an environmental challenge and suggests that changes in glutathione metabolism may be one means of integrating the function of several signaling pathways.},
number = {9},
urldate = {2021-06-15},
journal = {The Plant Cell},
author = {Ball, Louise and Accotto, Gian-Paolo and Bechtold, Ulrike and Creissen, Gary and Funck, Dietmar and Jimenez, Ana and Kular, Baldeep and Leyland, Nicola and Mejia-Carranza, Jaime and Reynolds, Helen and Karpinski, Stanislaw and Mullineaux, Philip M.},
month = sep,
year = {2004},
pages = {2448--2462},
}
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Mapping revealed that rax1-1 is an allele of γ-GLUTAMYLCYSTEINE SYNTHETASE 1 (GSH1), which encodes chloroplastic γ-glutamylcysteine synthetase, the controlling step of glutathione biosynthesis. By comparison of rax1-1 with the GSH1 mutant cadmium hypersensitive 2, the expression of 32 stress-responsive genes was shown to be responsive to changed glutathione metabolism. Under photo-oxidative stress conditions, the expression of a wider set of defense-related genes was altered in the mutants. In wild-type plants, glutathione metabolism may play a key role in determining the degree of expression of defense genes controlled by several signaling pathways both before and during stress. This control may reflect the physiological state of the plant at the time of the onset of an environmental challenge and suggests that changes in glutathione metabolism may be one means of integrating the function of several signaling pathways.","number":"9","urldate":"2021-06-15","journal":"The Plant Cell","author":[{"propositions":[],"lastnames":["Ball"],"firstnames":["Louise"],"suffixes":[]},{"propositions":[],"lastnames":["Accotto"],"firstnames":["Gian-Paolo"],"suffixes":[]},{"propositions":[],"lastnames":["Bechtold"],"firstnames":["Ulrike"],"suffixes":[]},{"propositions":[],"lastnames":["Creissen"],"firstnames":["Gary"],"suffixes":[]},{"propositions":[],"lastnames":["Funck"],"firstnames":["Dietmar"],"suffixes":[]},{"propositions":[],"lastnames":["Jimenez"],"firstnames":["Ana"],"suffixes":[]},{"propositions":[],"lastnames":["Kular"],"firstnames":["Baldeep"],"suffixes":[]},{"propositions":[],"lastnames":["Leyland"],"firstnames":["Nicola"],"suffixes":[]},{"propositions":[],"lastnames":["Mejia-Carranza"],"firstnames":["Jaime"],"suffixes":[]},{"propositions":[],"lastnames":["Reynolds"],"firstnames":["Helen"],"suffixes":[]},{"propositions":[],"lastnames":["Karpinski"],"firstnames":["Stanislaw"],"suffixes":[]},{"propositions":[],"lastnames":["Mullineaux"],"firstnames":["Philip","M."],"suffixes":[]}],"month":"September","year":"2004","pages":"2448–2462","bibtex":"@article{ball_evidence_2004,\n\ttitle = {Evidence for a {Direct} {Link} between {Glutathione} {Biosynthesis} and {Stress} {Defense} {Gene} {Expression} in {Arabidopsis}[{W}]},\n\tvolume = {16},\n\tissn = {1040-4651},\n\turl = {https://doi.org/10.1105/tpc.104.022608},\n\tdoi = {10/dnj446},\n\tabstract = {The mutant regulator of APX2 1-1 (rax1-1) was identified in Arabidopsis thaliana that constitutively expressed normally photooxidative stress-inducible ASCORBATE PEROXIDASE2 (APX2) and had ≥50\\% lowered foliar glutathione levels. Mapping revealed that rax1-1 is an allele of γ-GLUTAMYLCYSTEINE SYNTHETASE 1 (GSH1), which encodes chloroplastic γ-glutamylcysteine synthetase, the controlling step of glutathione biosynthesis. By comparison of rax1-1 with the GSH1 mutant cadmium hypersensitive 2, the expression of 32 stress-responsive genes was shown to be responsive to changed glutathione metabolism. Under photo-oxidative stress conditions, the expression of a wider set of defense-related genes was altered in the mutants. In wild-type plants, glutathione metabolism may play a key role in determining the degree of expression of defense genes controlled by several signaling pathways both before and during stress. 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