Higher interleukin-33 levels in aggressive periodontitis cases. Ballambettu, S. P., Pradeep, A. R., Purushottam, M., & Sen, S. Journal of Indian Society of Periodontology, 23(5):424–429, October, 2019. Place: Indiadoi abstract bibtex CONTEXT: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. AIMS: This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene. SETTINGS AND DESIGN: This is a cross-sectional, biochemical, genetic study. MATERIALS AND METHODS: Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. CONCLUSIONS: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.
@article{ballambettu_higher_2019,
title = {Higher interleukin-33 levels in aggressive periodontitis cases.},
volume = {23},
issn = {0972-124X},
doi = {10.4103/jisp.jisp_217_19},
abstract = {CONTEXT: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. AIMS: This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene. SETTINGS AND DESIGN: This is a cross-sectional, biochemical, genetic study. MATERIALS AND METHODS: Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. CONCLUSIONS: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.},
language = {eng},
number = {5},
journal = {Journal of Indian Society of Periodontology},
author = {Ballambettu, Sujatha Pai and Pradeep, A. R. and Purushottam, Meera and Sen, Somdatta},
month = oct,
year = {2019},
pmid = {31543615},
pmcid = {PMC6737856},
note = {Place: India},
keywords = {Aggressive periodontitis, chronic periodontitis, genetic polymorphism, gingival crevicular fluid, interleukin},
pages = {424--429},
}
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{"_id":"WibrMb6obMczDLTYh","bibbaseid":"ballambettu-pradeep-purushottam-sen-higherinterleukin33levelsinaggressiveperiodontitiscases-2019","author_short":["Ballambettu, S. P.","Pradeep, A. R.","Purushottam, M.","Sen, S."],"bibdata":{"bibtype":"article","type":"article","title":"Higher interleukin-33 levels in aggressive periodontitis cases.","volume":"23","issn":"0972-124X","doi":"10.4103/jisp.jisp_217_19","abstract":"CONTEXT: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. AIMS: This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene. SETTINGS AND DESIGN: This is a cross-sectional, biochemical, genetic study. MATERIALS AND METHODS: Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. CONCLUSIONS: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.","language":"eng","number":"5","journal":"Journal of Indian Society of Periodontology","author":[{"propositions":[],"lastnames":["Ballambettu"],"firstnames":["Sujatha","Pai"],"suffixes":[]},{"propositions":[],"lastnames":["Pradeep"],"firstnames":["A.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Purushottam"],"firstnames":["Meera"],"suffixes":[]},{"propositions":[],"lastnames":["Sen"],"firstnames":["Somdatta"],"suffixes":[]}],"month":"October","year":"2019","pmid":"31543615","pmcid":"PMC6737856","note":"Place: India","keywords":"Aggressive periodontitis, chronic periodontitis, genetic polymorphism, gingival crevicular fluid, interleukin","pages":"424–429","bibtex":"@article{ballambettu_higher_2019,\n\ttitle = {Higher interleukin-33 levels in aggressive periodontitis cases.},\n\tvolume = {23},\n\tissn = {0972-124X},\n\tdoi = {10.4103/jisp.jisp_217_19},\n\tabstract = {CONTEXT: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection. AIMS: This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene. SETTINGS AND DESIGN: This is a cross-sectional, biochemical, genetic study. MATERIALS AND METHODS: Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism. RESULTS: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33. CONCLUSIONS: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Journal of Indian Society of Periodontology},\n\tauthor = {Ballambettu, Sujatha Pai and Pradeep, A. R. and Purushottam, Meera and Sen, Somdatta},\n\tmonth = oct,\n\tyear = {2019},\n\tpmid = {31543615},\n\tpmcid = {PMC6737856},\n\tnote = {Place: India},\n\tkeywords = {Aggressive periodontitis, chronic periodontitis, genetic polymorphism, gingival crevicular fluid, interleukin},\n\tpages = {424--429},\n}\n\n","author_short":["Ballambettu, S. P.","Pradeep, A. R.","Purushottam, M.","Sen, S."],"key":"ballambettu_higher_2019","id":"ballambettu_higher_2019","bibbaseid":"ballambettu-pradeep-purushottam-sen-higherinterleukin33levelsinaggressiveperiodontitiscases-2019","role":"author","urls":{},"keyword":["Aggressive periodontitis","chronic periodontitis","genetic polymorphism","gingival crevicular fluid","interleukin"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/13355736/collections/3CAWAWXC/items?key=vRFNBjbSZn1EI2DS1CUS6woU&format=bibtex&limit=100","dataSources":["JBS8CagaA2NEYTD7x","NGymCCPoKRMFPMiiu","u7w3REH2CiFYcCrmn"],"keywords":["aggressive periodontitis","chronic periodontitis","genetic polymorphism","gingival crevicular fluid","interleukin"],"search_terms":["higher","interleukin","levels","aggressive","periodontitis","cases","ballambettu","pradeep","purushottam","sen"],"title":"Higher interleukin-33 levels in aggressive periodontitis cases.","year":2019}