(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Ballon, N., Leroy, S., Roy, C., Bourdel, M. C., Charles-Nicolas, A., Krebs, M. O., & Poirier, M. F. The Pharmacogenomics Journal, 6(2):126--130, April, 2006. doi abstract bibtex Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P \textless 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P \textless 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.
@article{ ballon_aatn_2006,
title = {({AAT})n repeat in the cannabinoid receptor gene ({CNR}1): association with cocaine addiction in an African-Caribbean population},
volume = {6},
issn = {1470-269X},
shorttitle = {({AAT})n repeat in the cannabinoid receptor gene ({CNR}1)},
doi = {10.1038/sj.tpj.6500352},
abstract = {Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the ({AAT})n triplet repeat polymorphism nearby the {CNR}1 gene, which encodes human cannabinoid ({CB}1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P {\textless} 10(-4)). The frequency of the ({AAT})12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P {\textless} 10(-4)). Our results support that the ({AAT})n polymorphism nearby the {CNR}1 gene could be associated with predisposition to cocaine dependency.},
language = {eng},
number = {2},
journal = {The Pharmacogenomics Journal},
author = {Ballon, N. and Leroy, S. and Roy, C. and Bourdel, M. C. and Charles-Nicolas, A. and Krebs, M. O. and Poirier, M. F.},
month = {April},
year = {2006},
pmid = {16314880},
keywords = {Adult, African Continental Ancestry Group, Animals, Cell Adhesion Molecules, Neuronal, Cocaine-Related Disorders, {DNA}, Female, Gene Frequency, Humans, Male, Martinique, Neuropeptides, Polymorphism, Genetic, Receptors, Cell Surface, Schizophrenia, Trinucleotide Repeats},
pages = {126--130}
}
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The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P \\textless 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.","author":["Ballon, N.","Leroy, S.","Roy, C.","Bourdel, M. C.","Charles-Nicolas, A.","Krebs, M. O.","Poirier, M. F."],"author_short":["Ballon, N.","Leroy, S.","Roy, C.","Bourdel, M.<nbsp>C.","Charles-Nicolas, A.","Krebs, M.<nbsp>O.","Poirier, M.<nbsp>F."],"bibtex":"@article{ ballon_aatn_2006,\n title = {({AAT})n repeat in the cannabinoid receptor gene ({CNR}1): association with cocaine addiction in an African-Caribbean population},\n volume = {6},\n issn = {1470-269X},\n shorttitle = {({AAT})n repeat in the cannabinoid receptor gene ({CNR}1)},\n doi = {10.1038/sj.tpj.6500352},\n abstract = {Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the ({AAT})n triplet repeat polymorphism nearby the {CNR}1 gene, which encodes human cannabinoid ({CB}1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P {\\textless} 10(-4)). The frequency of the ({AAT})12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P {\\textless} 10(-4)). Our results support that the ({AAT})n polymorphism nearby the {CNR}1 gene could be associated with predisposition to cocaine dependency.},\n language = {eng},\n number = {2},\n journal = {The Pharmacogenomics Journal},\n author = {Ballon, N. and Leroy, S. and Roy, C. and Bourdel, M. C. and Charles-Nicolas, A. and Krebs, M. O. and Poirier, M. 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