(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Ballon, N., Leroy, S., Roy, C., Bourdel, M. C., Charles-Nicolas, A., Krebs, M. O., & Poirier, M. F. The Pharmacogenomics Journal, 6(2):126--130, April, 2006.
doi  abstract   bibtex   
Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P \textless 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P \textless 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.
@article{ ballon_aatn_2006,
  title = {({AAT})n repeat in the cannabinoid receptor gene ({CNR}1): association with cocaine addiction in an African-Caribbean population},
  volume = {6},
  issn = {1470-269X},
  shorttitle = {({AAT})n repeat in the cannabinoid receptor gene ({CNR}1)},
  doi = {10.1038/sj.tpj.6500352},
  abstract = {Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the ({AAT})n triplet repeat polymorphism nearby the {CNR}1 gene, which encodes human cannabinoid ({CB}1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P {\textless} 10(-4)). The frequency of the ({AAT})12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P {\textless} 10(-4)). Our results support that the ({AAT})n polymorphism nearby the {CNR}1 gene could be associated with predisposition to cocaine dependency.},
  language = {eng},
  number = {2},
  journal = {The Pharmacogenomics Journal},
  author = {Ballon, N. and Leroy, S. and Roy, C. and Bourdel, M. C. and Charles-Nicolas, A. and Krebs, M. O. and Poirier, M. F.},
  month = {April},
  year = {2006},
  pmid = {16314880},
  keywords = {Adult, African Continental Ancestry Group, Animals, Cell Adhesion Molecules, Neuronal, Cocaine-Related Disorders, {DNA}, Female, Gene Frequency, Humans, Male, Martinique, Neuropeptides, Polymorphism, Genetic, Receptors, Cell Surface, Schizophrenia, Trinucleotide Repeats},
  pages = {126--130}
}

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