A hypercapnia-based normalization method for improved spatial localization of human brain activation with fMRI. Bandettini, P A & Wong, E C NMR in Biomedicine, 10(4-5):197--203, June, 1997. Paper abstract bibtex An issue in blood oxygenation level dependent contrast-based functional MRI is the accurate interpretation of the activation-induced signal changes. Hemodynamic factors other than activation-induced changes in blood oxygenation are known to contribute to the signal change magnitudes and dynamics, and therefore need to be accounted for or removed. In this paper, a general method for removal of effects other than activation-induced blood oxygenation changes from fMRI brain activation maps by the use of hypercapnic stress normalization is introduced. First, the effects of resting blood volume distribution across voxels on activation-induced BOLD-based fMRI signal changes are shown to be significant. Second, the effects of hypercapnia and hypoxia on resting and activation-induced signal changes are demonstrated. These results suggest that global hemodynamic stresses may be useful for non-invasive mapping of blood volume. Third, the normalization technique is demonstrated.
@article{bandettini_hypercapnia-based_1997,
title = {A hypercapnia-based normalization method for improved spatial localization of human brain activation with {fMRI}},
volume = {10},
issn = {0952-3480},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9430348},
abstract = {An issue in blood oxygenation level dependent contrast-based functional MRI is the accurate interpretation of the activation-induced signal changes. Hemodynamic factors other than activation-induced changes in blood oxygenation are known to contribute to the signal change magnitudes and dynamics, and therefore need to be accounted for or removed. In this paper, a general method for removal of effects other than activation-induced blood oxygenation changes from fMRI brain activation maps by the use of hypercapnic stress normalization is introduced. First, the effects of resting blood volume distribution across voxels on activation-induced BOLD-based fMRI signal changes are shown to be significant. Second, the effects of hypercapnia and hypoxia on resting and activation-induced signal changes are demonstrated. These results suggest that global hemodynamic stresses may be useful for non-invasive mapping of blood volume. Third, the normalization technique is demonstrated.},
number = {4-5},
urldate = {2009-02-13},
journal = {NMR in Biomedicine},
author = {Bandettini, P A and Wong, E C},
month = jun,
year = {1997},
pmid = {9430348},
keywords = {ASL, BOLD, hypercapnia, calibratedBOLD, CO2},
pages = {197--203},
file = {bandettini1997.pdf:/Users/nickb/Zotero/storage/TWGW8IWM/bandettini1997.pdf:application/pdf;PubMed Snapshot:/Users/nickb/Zotero/storage/AG78NKN3/entrez.html:text/html}
}
Downloads: 0
{"_id":"3R9YNJwoSBqA5potD","bibbaseid":"bandettini-wong-ahypercapniabasednormalizationmethodforimprovedspatiallocalizationofhumanbrainactivationwithfmri-1997","downloads":0,"creationDate":"2017-07-20T09:27:29.280Z","title":"A hypercapnia-based normalization method for improved spatial localization of human brain activation with fMRI","author_short":["Bandettini, P A","Wong, E C"],"year":1997,"bibtype":"article","biburl":"https://users.fmrib.ox.ac.uk/~nickb/ExportedItemsLge.bib","bibdata":{"bibtype":"article","type":"article","title":"A hypercapnia-based normalization method for improved spatial localization of human brain activation with fMRI","volume":"10","issn":"0952-3480","url":"http://www.ncbi.nlm.nih.gov/pubmed/9430348","abstract":"An issue in blood oxygenation level dependent contrast-based functional MRI is the accurate interpretation of the activation-induced signal changes. Hemodynamic factors other than activation-induced changes in blood oxygenation are known to contribute to the signal change magnitudes and dynamics, and therefore need to be accounted for or removed. In this paper, a general method for removal of effects other than activation-induced blood oxygenation changes from fMRI brain activation maps by the use of hypercapnic stress normalization is introduced. First, the effects of resting blood volume distribution across voxels on activation-induced BOLD-based fMRI signal changes are shown to be significant. Second, the effects of hypercapnia and hypoxia on resting and activation-induced signal changes are demonstrated. These results suggest that global hemodynamic stresses may be useful for non-invasive mapping of blood volume. Third, the normalization technique is demonstrated.","number":"4-5","urldate":"2009-02-13","journal":"NMR in Biomedicine","author":[{"propositions":[],"lastnames":["Bandettini"],"firstnames":["P","A"],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["E","C"],"suffixes":[]}],"month":"June","year":"1997","pmid":"9430348","keywords":"ASL, BOLD, hypercapnia, calibratedBOLD, CO2","pages":"197--203","file":"bandettini1997.pdf:/Users/nickb/Zotero/storage/TWGW8IWM/bandettini1997.pdf:application/pdf;PubMed Snapshot:/Users/nickb/Zotero/storage/AG78NKN3/entrez.html:text/html","bibtex":"@article{bandettini_hypercapnia-based_1997,\n\ttitle = {A hypercapnia-based normalization method for improved spatial localization of human brain activation with {fMRI}},\n\tvolume = {10},\n\tissn = {0952-3480},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/9430348},\n\tabstract = {An issue in blood oxygenation level dependent contrast-based functional MRI is the accurate interpretation of the activation-induced signal changes. Hemodynamic factors other than activation-induced changes in blood oxygenation are known to contribute to the signal change magnitudes and dynamics, and therefore need to be accounted for or removed. In this paper, a general method for removal of effects other than activation-induced blood oxygenation changes from fMRI brain activation maps by the use of hypercapnic stress normalization is introduced. First, the effects of resting blood volume distribution across voxels on activation-induced BOLD-based fMRI signal changes are shown to be significant. Second, the effects of hypercapnia and hypoxia on resting and activation-induced signal changes are demonstrated. These results suggest that global hemodynamic stresses may be useful for non-invasive mapping of blood volume. Third, the normalization technique is demonstrated.},\n\tnumber = {4-5},\n\turldate = {2009-02-13},\n\tjournal = {NMR in Biomedicine},\n\tauthor = {Bandettini, P A and Wong, E C},\n\tmonth = jun,\n\tyear = {1997},\n\tpmid = {9430348},\n\tkeywords = {ASL, BOLD, hypercapnia, calibratedBOLD, CO2},\n\tpages = {197--203},\n\tfile = {bandettini1997.pdf:/Users/nickb/Zotero/storage/TWGW8IWM/bandettini1997.pdf:application/pdf;PubMed Snapshot:/Users/nickb/Zotero/storage/AG78NKN3/entrez.html:text/html}\n}\n\n","author_short":["Bandettini, P A","Wong, E C"],"key":"bandettini_hypercapnia-based_1997","id":"bandettini_hypercapnia-based_1997","bibbaseid":"bandettini-wong-ahypercapniabasednormalizationmethodforimprovedspatiallocalizationofhumanbrainactivationwithfmri-1997","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/9430348"},"keyword":["ASL","BOLD","hypercapnia","calibratedBOLD","CO2"],"downloads":0,"html":""},"search_terms":["hypercapnia","based","normalization","method","improved","spatial","localization","human","brain","activation","fmri","bandettini","wong"],"keywords":["asl","bold","hypercapnia","calibratedbold","co2"],"authorIDs":[],"dataSources":["ZnSCiZ543imjXQzRu"]}