P450s controlling metabolic bifurcations in plant terpene specialized metabolism. Banerjee, A. & Hamberger, B. DOI 10.1007/s11101-017-9530-4:DOI 10.1007/s11101-017-9530-4, 2017. ![P450s controlling metabolic bifurcations in plant terpene specialized metabolism [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper doi abstract bibtex Catalyzing stereo- and regio-specific oxi- dation of inert hydrocarbon backbones, and a range of more exotic reactions inherently difficult in formal chemical synthesis, cytochromes P450 (P450s) offer outstanding potential for biotechnological engineer- ing. Plants and their dazzling diversity of specialized metabolites have emerged as rich repository for functional P450s with the advances of deep transcrip- tomics and genome wide discovery. P450s are of outstanding interest for understanding chemical diver- sification throughout evolution, for gaining mechanis- tic insights through the study of their structure--function relationship, and for exploitation in Synthetic Biology. In this review, we highlight recent develop- ments and examples in the discovery of plant P450s involved in the biosynthesis of industrially relevant monoterpenoids, sesquiterpenoids, diterpenoids and triterpenoids, throughout 2016 and early 2017. Exam- ples were selected to illustrate the spectrum of value from commodity chemicals, flavor and fragrance compounds to pharmacologically active terpenoids. We focus on a recently emerging theme, where P450s control metabolic bifurcations and chemical diversity of the final product profile, either within a pathway, or through neo-functionalization in related species. The implications may inform approaches for rational assembly of recombinant pathways, biotechnological production of high value terpenoids and generation of novel chemical entities.
@article{Banerjee:2017aa,
Abstract = {Catalyzing stereo- and regio-specific oxi- dation of inert hydrocarbon backbones, and a range of more exotic reactions inherently difficult in formal chemical synthesis, cytochromes P450 (P450s) offer outstanding potential for biotechnological engineer- ing. Plants and their dazzling diversity of specialized metabolites have emerged as rich repository for functional P450s with the advances of deep transcrip- tomics and genome wide discovery. P450s are of outstanding interest for understanding chemical diver- sification throughout evolution, for gaining mechanis- tic insights through the study of their structure--function relationship, and for exploitation in Synthetic Biology. In this review, we highlight recent develop- ments and examples in the discovery of plant P450s involved in the biosynthesis of industrially relevant monoterpenoids, sesquiterpenoids, diterpenoids and triterpenoids, throughout 2016 and early 2017. Exam- ples were selected to illustrate the spectrum of value from commodity chemicals, flavor and fragrance compounds to pharmacologically active terpenoids. We focus on a recently emerging theme, where P450s control metabolic bifurcations and chemical diversity of the final product profile, either within a pathway, or through neo-functionalization in related species. The implications may inform approaches for rational assembly of recombinant pathways, biotechnological production of high value terpenoids and generation of novel chemical entities.},
Annote = {FL verified 11-8-17 EZ},
Author = {Banerjee, Aparajita and Hamberger, Bj{\"o}rn},
Booktitle = {Phytochemistry Reviews},
Date-Added = {2017-11-17 17:51:47 +0000},
Date-Modified = {2017-11-17 17:51:47 +0000},
Doi = {10.1007/s11101-017-9530-4},
Et = {August 20, 2017},
Id = {1135},
Lb = {Y10Q3 A1},
Local-Url = {internal-pdf://1734575189/Banerjee_Hamberger_2017.pdf},
Pages = {DOI 10.1007/s11101-017-9530-4},
Rn = {1.3.4},
St = {P450s controlling metabolic bifurcations in plant terpene specialized metabolism},
Title = {P450s controlling metabolic bifurcations in plant terpene specialized metabolism},
Ty = {JOUR},
Url = {https://link.springer.com/content/pdf/10.1007%2Fs11101-017-9530-4.pdf},
Volume = {DOI 10.1007/s11101-017-9530-4},
Year = {2017},
Bdsk-Url-1 = {https://link.springer.com/content/pdf/10.1007%2Fs11101-017-9530-4.pdf},
Bdsk-Url-2 = {http://dx.doi.org/10.1007/s11101-017-9530-4}}
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