Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference. Baracz, S. J., Rourke, P. I., Pardey, M. C., Hunt, G. E., McGregor, I. S., & Cornish, J. L. Behavioural Brain Research, 228(1):185–193, March, 2012. ![Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Accumulating evidence indicates that the neuropeptide oxytocin (OXY) may modulate reward-related behavioural responses to methamphetamine (METH) administration. Limited research has examined the effect of OXY on METH-induced conditioned place preference (CPP) and little is known about the neural mechanisms involved. A Fos immunohistochemistry study recently demonstrated that peripheral OXY administration reduced METH-induced Fos expression within the nucleus accumbens (NAc) core and subthalamic nucleus (STh) in rats. The current study aimed to (i) investigate the effect of systemically administered OXY on METH-induced CPP, (ii) determine the effectiveness of a single-trial CPP procedure with METH, in order to (iii) evaluate whether pretreatment with OXY injected directly into the NAc core or the STh attenuates METH-induced CPP. Results showed that male Sprague Dawley rats learned to associate unique compartmental cues with METH (1mg/kg, i.p.) such that they spent more time in the METH-paired compartment and less time in the saline-paired compartment. Pretreatment with systemic OXY (0.6mg, i.p.), or OXY (0.6ng, i.c.) microinjected into the NAc core or the STh prior to METH administration attenuated the formation of a CPP to METH. This provides further evidence that OXY acts within either the NAc core or the STh to reduce the rewarding effects of METH administration.
@article{baracz_oxytocin_2012,
title = {Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference},
volume = {228},
issn = {0166-4328},
url = {https://www.sciencedirect.com/science/article/pii/S0166432811008370},
doi = {10.1016/j.bbr.2011.11.038},
abstract = {Accumulating evidence indicates that the neuropeptide oxytocin (OXY) may modulate reward-related behavioural responses to methamphetamine (METH) administration. Limited research has examined the effect of OXY on METH-induced conditioned place preference (CPP) and little is known about the neural mechanisms involved. A Fos immunohistochemistry study recently demonstrated that peripheral OXY administration reduced METH-induced Fos expression within the nucleus accumbens (NAc) core and subthalamic nucleus (STh) in rats. The current study aimed to (i) investigate the effect of systemically administered OXY on METH-induced CPP, (ii) determine the effectiveness of a single-trial CPP procedure with METH, in order to (iii) evaluate whether pretreatment with OXY injected directly into the NAc core or the STh attenuates METH-induced CPP. Results showed that male Sprague Dawley rats learned to associate unique compartmental cues with METH (1mg/kg, i.p.) such that they spent more time in the METH-paired compartment and less time in the saline-paired compartment. Pretreatment with systemic OXY (0.6mg, i.p.), or OXY (0.6ng, i.c.) microinjected into the NAc core or the STh prior to METH administration attenuated the formation of a CPP to METH. This provides further evidence that OXY acts within either the NAc core or the STh to reduce the rewarding effects of METH administration.},
language = {en},
number = {1},
urldate = {2023-06-07},
journal = {Behavioural Brain Research},
author = {Baracz, Sarah J. and Rourke, Poppy I. and Pardey, Margery C. and Hunt, Glenn E. and McGregor, Iain S. and Cornish, Jennifer L.},
month = mar,
year = {2012},
keywords = {Conditioned place preference, Methamphetamine, Nucleus accumbens core, Oxytocin, Subthalamic nucleus},
pages = {185--193},
}
Downloads: 0
{"_id":"bJ2DkTQmfMZS3a6GH","bibbaseid":"baracz-rourke-pardey-hunt-mcgregor-cornish-oxytocindirectlyadministeredintothenucleusaccumbenscoreorsubthalamicnucleusattenuatesmethamphetamineinducedconditionedplacepreference-2012","author_short":["Baracz, S. J.","Rourke, P. I.","Pardey, M. C.","Hunt, G. E.","McGregor, I. S.","Cornish, J. L."],"bibdata":{"bibtype":"article","type":"article","title":"Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference","volume":"228","issn":"0166-4328","url":"https://www.sciencedirect.com/science/article/pii/S0166432811008370","doi":"10.1016/j.bbr.2011.11.038","abstract":"Accumulating evidence indicates that the neuropeptide oxytocin (OXY) may modulate reward-related behavioural responses to methamphetamine (METH) administration. Limited research has examined the effect of OXY on METH-induced conditioned place preference (CPP) and little is known about the neural mechanisms involved. A Fos immunohistochemistry study recently demonstrated that peripheral OXY administration reduced METH-induced Fos expression within the nucleus accumbens (NAc) core and subthalamic nucleus (STh) in rats. The current study aimed to (i) investigate the effect of systemically administered OXY on METH-induced CPP, (ii) determine the effectiveness of a single-trial CPP procedure with METH, in order to (iii) evaluate whether pretreatment with OXY injected directly into the NAc core or the STh attenuates METH-induced CPP. Results showed that male Sprague Dawley rats learned to associate unique compartmental cues with METH (1mg/kg, i.p.) such that they spent more time in the METH-paired compartment and less time in the saline-paired compartment. Pretreatment with systemic OXY (0.6mg, i.p.), or OXY (0.6ng, i.c.) microinjected into the NAc core or the STh prior to METH administration attenuated the formation of a CPP to METH. This provides further evidence that OXY acts within either the NAc core or the STh to reduce the rewarding effects of METH administration.","language":"en","number":"1","urldate":"2023-06-07","journal":"Behavioural Brain Research","author":[{"propositions":[],"lastnames":["Baracz"],"firstnames":["Sarah","J."],"suffixes":[]},{"propositions":[],"lastnames":["Rourke"],"firstnames":["Poppy","I."],"suffixes":[]},{"propositions":[],"lastnames":["Pardey"],"firstnames":["Margery","C."],"suffixes":[]},{"propositions":[],"lastnames":["Hunt"],"firstnames":["Glenn","E."],"suffixes":[]},{"propositions":[],"lastnames":["McGregor"],"firstnames":["Iain","S."],"suffixes":[]},{"propositions":[],"lastnames":["Cornish"],"firstnames":["Jennifer","L."],"suffixes":[]}],"month":"March","year":"2012","keywords":"Conditioned place preference, Methamphetamine, Nucleus accumbens core, Oxytocin, Subthalamic nucleus","pages":"185–193","bibtex":"@article{baracz_oxytocin_2012,\n\ttitle = {Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference},\n\tvolume = {228},\n\tissn = {0166-4328},\n\turl = {https://www.sciencedirect.com/science/article/pii/S0166432811008370},\n\tdoi = {10.1016/j.bbr.2011.11.038},\n\tabstract = {Accumulating evidence indicates that the neuropeptide oxytocin (OXY) may modulate reward-related behavioural responses to methamphetamine (METH) administration. Limited research has examined the effect of OXY on METH-induced conditioned place preference (CPP) and little is known about the neural mechanisms involved. A Fos immunohistochemistry study recently demonstrated that peripheral OXY administration reduced METH-induced Fos expression within the nucleus accumbens (NAc) core and subthalamic nucleus (STh) in rats. The current study aimed to (i) investigate the effect of systemically administered OXY on METH-induced CPP, (ii) determine the effectiveness of a single-trial CPP procedure with METH, in order to (iii) evaluate whether pretreatment with OXY injected directly into the NAc core or the STh attenuates METH-induced CPP. Results showed that male Sprague Dawley rats learned to associate unique compartmental cues with METH (1mg/kg, i.p.) such that they spent more time in the METH-paired compartment and less time in the saline-paired compartment. Pretreatment with systemic OXY (0.6mg, i.p.), or OXY (0.6ng, i.c.) microinjected into the NAc core or the STh prior to METH administration attenuated the formation of a CPP to METH. This provides further evidence that OXY acts within either the NAc core or the STh to reduce the rewarding effects of METH administration.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2023-06-07},\n\tjournal = {Behavioural Brain Research},\n\tauthor = {Baracz, Sarah J. and Rourke, Poppy I. and Pardey, Margery C. and Hunt, Glenn E. and McGregor, Iain S. and Cornish, Jennifer L.},\n\tmonth = mar,\n\tyear = {2012},\n\tkeywords = {Conditioned place preference, Methamphetamine, Nucleus accumbens core, Oxytocin, Subthalamic nucleus},\n\tpages = {185--193},\n}\n\n","author_short":["Baracz, S. J.","Rourke, P. I.","Pardey, M. C.","Hunt, G. E.","McGregor, I. S.","Cornish, J. L."],"key":"baracz_oxytocin_2012","id":"baracz_oxytocin_2012","bibbaseid":"baracz-rourke-pardey-hunt-mcgregor-cornish-oxytocindirectlyadministeredintothenucleusaccumbenscoreorsubthalamicnucleusattenuatesmethamphetamineinducedconditionedplacepreference-2012","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/S0166432811008370"},"keyword":["Conditioned place preference","Methamphetamine","Nucleus accumbens core","Oxytocin","Subthalamic nucleus"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/tub49573","dataSources":["zdB47AZpEkG3LzPTn"],"keywords":["conditioned place preference","methamphetamine","nucleus accumbens core","oxytocin","subthalamic nucleus"],"search_terms":["oxytocin","directly","administered","nucleus","accumbens","core","subthalamic","nucleus","attenuates","methamphetamine","induced","conditioned","place","preference","baracz","rourke","pardey","hunt","mcgregor","cornish"],"title":"Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference","year":2012}