The Evolving Treatment Landscape of Advanced Renal Cell Carcinoma in Patients Progressing after VEGF Inhibition. Barata, P. C., Ornstein, M. C., & Garcia, J. A. Journal of kidney cancer and VHL, 4(2):10–18, 2017.
doi  abstract   bibtex   
Despite significant changes in the therapeutic landscape of renal cell carcinoma, the majority of patients with metastatic disease eventually progress after first-line treatment with vascular endothelial growth factor receptors (VEGFR) tyrosine kinase inhibitor (TKI) therapy. Understanding existing data on subsequent therapies is crucial to define an optimal treatment sequence following first-line failure. This review examines the data supporting currently approved agents in this setting and provides a framework for decision-making regarding treatment sequencing beyond first-line therapy with VEGFR TKIs.
@article{barata_evolving_2017,
	title = {The {Evolving} {Treatment} {Landscape} of {Advanced} {Renal} {Cell} {Carcinoma} in {Patients} {Progressing} after {VEGF} {Inhibition}},
	volume = {4},
	issn = {2203-5826},
	doi = {10.15586/jkcvhl.2017.69},
	abstract = {Despite significant changes in the therapeutic landscape of renal cell carcinoma, the majority of patients with metastatic disease eventually progress after first-line treatment with vascular endothelial growth factor receptors (VEGFR) tyrosine kinase inhibitor (TKI) therapy. Understanding existing data on subsequent therapies is crucial to define an optimal treatment sequence following first-line failure. This review examines the data supporting currently approved agents in this setting and provides a framework for decision-making regarding treatment sequencing beyond first-line therapy with VEGFR TKIs.},
	language = {eng},
	number = {2},
	journal = {Journal of kidney cancer and VHL},
	author = {Barata, Pedro C. and Ornstein, Moshe C. and Garcia, Jorge A.},
	year = {2017},
	pmid = {28725539},
	pmcid = {PMC5515898},
	keywords = {Clear Cell Renal Cell Carcinoma, Kidney, ccRCC},
	pages = {10--18},
}

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