Approaches to limit systemic antibiotic use in acne: Systemic alternatives, emerging topical therapies, dietary modification, and laser and light-based treatments. Barbieri, J. S., Spaccarelli, N., Margolis, D. J., & James, W. D. Journal of the American Academy of Dermatology, 80(2):538–549, February, 2019. doi abstract bibtex Acne is one of the most common diseases worldwide and affects ∼50 million individuals in the United States. Oral antibiotics are the most common systemic agent prescribed for the treatment of acne. However, their use might be associated with a variety of adverse outcomes including bacterial resistance and disruption of the microbiome. As a result, multiple treatment guidelines call for limiting the use of oral antibiotics in the treatment of acne, although actual prescribing often does not follow these guidelines. In this review, the rationale for concerns regarding the use of oral antibiotics for the management of acne is reviewed. In addition, we will discuss our approach to complying with the intent of the guidelines, with a focus on novel topical agents, dietary modification, laser and light-based modalities, and systemic medications, such as spironolactone, combined oral contraceptives, and oral isotretinoin.
@article{barbieri_approaches_2019-1,
title = {Approaches to limit systemic antibiotic use in acne: {Systemic} alternatives, emerging topical therapies, dietary modification, and laser and light-based treatments},
volume = {80},
issn = {1097-6787},
shorttitle = {Approaches to limit systemic antibiotic use in acne},
doi = {10.1016/j.jaad.2018.09.055},
abstract = {Acne is one of the most common diseases worldwide and affects ∼50 million individuals in the United States. Oral antibiotics are the most common systemic agent prescribed for the treatment of acne. However, their use might be associated with a variety of adverse outcomes including bacterial resistance and disruption of the microbiome. As a result, multiple treatment guidelines call for limiting the use of oral antibiotics in the treatment of acne, although actual prescribing often does not follow these guidelines. In this review, the rationale for concerns regarding the use of oral antibiotics for the management of acne is reviewed. In addition, we will discuss our approach to complying with the intent of the guidelines, with a focus on novel topical agents, dietary modification, laser and light-based modalities, and systemic medications, such as spironolactone, combined oral contraceptives, and oral isotretinoin.},
language = {eng},
number = {2},
journal = {Journal of the American Academy of Dermatology},
author = {Barbieri, John S. and Spaccarelli, Natalie and Margolis, David J. and James, William D.},
month = feb,
year = {2019},
pmid = {30296534},
pmcid = {PMC6333507},
keywords = {Postdoctoral Trainee - Barbieri, Trainer - Margolis},
pages = {538--549},
}
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