Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo. Barnes, S., J., Sammons, R., P., Jacobsen, R., I., Mackie, J., Keller, G., B., & Keck, T. Neuron, 86(5):1290-303, 6, 2015. ![Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.
@article{
title = {Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo.},
type = {article},
year = {2015},
identifiers = {[object Object]},
keywords = {Animals,Female,Homeostasis,Homeostasis: physiology,Male,Mice,Mice, Inbred C57BL,Nerve Net,Nerve Net: physiology,Neuronal Plasticity,Neuronal Plasticity: physiology,Photic Stimulation,Photic Stimulation: methods,Sensory Deprivation,Sensory Deprivation: physiology,Visual Cortex,Visual Cortex: physiology,Visual Pathways,Visual Pathways: physiology},
pages = {1290-303},
volume = {86},
websites = {http://www.sciencedirect.com/science/article/pii/S0896627315004171},
month = {6},
day = {3},
id = {570f4aa4-00d6-3d2c-a463-f0f56e9e2820},
created = {2016-10-18T09:31:38.000Z},
accessed = {2016-06-06},
file_attached = {false},
profile_id = {a284bdcb-0ee1-3dea-9317-7f47c0e9b4ec},
group_id = {9e2da818-7db2-32de-9369-b0c1c4c7aea1},
last_modified = {2016-10-18T09:31:39.000Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
citation_key = {Barnes2015},
abstract = {Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.},
bibtype = {article},
author = {Barnes, Samuel J and Sammons, Rosanna P and Jacobsen, R Irene and Mackie, Jennifer and Keller, Georg B and Keck, Tara},
journal = {Neuron},
number = {5}
}
Downloads: 0
{"_id":"9ikh9Jza9AeS8prKa","bibbaseid":"barnes-sammons-jacobsen-mackie-keller-keck-subnetworkspecifichomeostaticplasticityinmousevisualcortexinvivo-2015","downloads":0,"creationDate":"2016-10-18T09:55:23.093Z","title":"Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo.","author_short":["Barnes, S., J.","Sammons, R., P.","Jacobsen, R., I.","Mackie, J.","Keller, G., B.","Keck, T."],"year":2015,"bibtype":"article","biburl":null,"bibdata":{"title":"Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo.","type":"article","year":"2015","identifiers":"[object Object]","keywords":"Animals,Female,Homeostasis,Homeostasis: physiology,Male,Mice,Mice, Inbred C57BL,Nerve Net,Nerve Net: physiology,Neuronal Plasticity,Neuronal Plasticity: physiology,Photic Stimulation,Photic Stimulation: methods,Sensory Deprivation,Sensory Deprivation: physiology,Visual Cortex,Visual Cortex: physiology,Visual Pathways,Visual Pathways: physiology","pages":"1290-303","volume":"86","websites":"http://www.sciencedirect.com/science/article/pii/S0896627315004171","month":"6","day":"3","id":"570f4aa4-00d6-3d2c-a463-f0f56e9e2820","created":"2016-10-18T09:31:38.000Z","accessed":"2016-06-06","file_attached":false,"profile_id":"a284bdcb-0ee1-3dea-9317-7f47c0e9b4ec","group_id":"9e2da818-7db2-32de-9369-b0c1c4c7aea1","last_modified":"2016-10-18T09:31:39.000Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"citation_key":"Barnes2015","abstract":"Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.","bibtype":"article","author":"Barnes, Samuel J and Sammons, Rosanna P and Jacobsen, R Irene and Mackie, Jennifer and Keller, Georg B and Keck, Tara","journal":"Neuron","number":"5","bibtex":"@article{\n title = {Subnetwork-Specific Homeostatic Plasticity in Mouse Visual Cortex In Vivo.},\n type = {article},\n year = {2015},\n identifiers = {[object Object]},\n keywords = {Animals,Female,Homeostasis,Homeostasis: physiology,Male,Mice,Mice, Inbred C57BL,Nerve Net,Nerve Net: physiology,Neuronal Plasticity,Neuronal Plasticity: physiology,Photic Stimulation,Photic Stimulation: methods,Sensory Deprivation,Sensory Deprivation: physiology,Visual Cortex,Visual Cortex: physiology,Visual Pathways,Visual Pathways: physiology},\n pages = {1290-303},\n volume = {86},\n websites = {http://www.sciencedirect.com/science/article/pii/S0896627315004171},\n month = {6},\n day = {3},\n id = {570f4aa4-00d6-3d2c-a463-f0f56e9e2820},\n created = {2016-10-18T09:31:38.000Z},\n accessed = {2016-06-06},\n file_attached = {false},\n profile_id = {a284bdcb-0ee1-3dea-9317-7f47c0e9b4ec},\n group_id = {9e2da818-7db2-32de-9369-b0c1c4c7aea1},\n last_modified = {2016-10-18T09:31:39.000Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n citation_key = {Barnes2015},\n abstract = {Homeostatic regulation has been shown to restore cortical activity in vivo following sensory deprivation, but it is unclear whether this recovery is uniform across all cells or specific to a subset of the network. To address this issue, we used chronic calcium imaging in behaving adult mice to examine the activity of individual excitatory and inhibitory neurons in the same region of the layer 2/3 monocular visual cortex following enucleation. We found that only a fraction of excitatory neurons homeostatically recover activity after deprivation and inhibitory neurons show no recovery. Prior to deprivation, excitatory cells that did recover were more likely to have significantly correlated activity with other recovering excitatory neurons, thus forming a subnetwork of recovering neurons. These network level changes are accompanied by a reduction in synaptic inhibition onto all excitatory neurons, suggesting that both synaptic mechanisms and subnetwork activity are important for homeostatic recovery of activity after deprivation.},\n bibtype = {article},\n author = {Barnes, Samuel J and Sammons, Rosanna P and Jacobsen, R Irene and Mackie, Jennifer and Keller, Georg B and Keck, Tara},\n journal = {Neuron},\n number = {5}\n}","author_short":["Barnes, S., J.","Sammons, R., P.","Jacobsen, R., I.","Mackie, J.","Keller, G., B.","Keck, T."],"urls":{"Website":"http://www.sciencedirect.com/science/article/pii/S0896627315004171"},"bibbaseid":"barnes-sammons-jacobsen-mackie-keller-keck-subnetworkspecifichomeostaticplasticityinmousevisualcortexinvivo-2015","role":"author","keyword":["Animals","Female","Homeostasis","Homeostasis: physiology","Male","Mice","Mice","Inbred C57BL","Nerve Net","Nerve Net: physiology","Neuronal Plasticity","Neuronal Plasticity: physiology","Photic Stimulation","Photic Stimulation: methods","Sensory Deprivation","Sensory Deprivation: physiology","Visual Cortex","Visual Cortex: physiology","Visual Pathways","Visual Pathways: physiology"],"downloads":0},"search_terms":["subnetwork","specific","homeostatic","plasticity","mouse","visual","cortex","vivo","barnes","sammons","jacobsen","mackie","keller","keck"],"keywords":["animals","female","homeostasis","homeostasis: physiology","male","mice","mice","inbred c57bl","nerve net","nerve net: physiology","neuronal plasticity","neuronal plasticity: physiology","photic stimulation","photic stimulation: methods","sensory deprivation","sensory deprivation: physiology","visual cortex","visual cortex: physiology","visual pathways","visual pathways: physiology"],"authorIDs":[]}