@article{barragn-campos2015diagnosis,
	title        = {Diagnosis and {{Treatment Options}} of {{Spinal Metastases}}},
	author       = {
		{Barrag{\'a}n-Campos}, H{\'e}ctor Manuel and {Jim{\'e}nez-Zaraz{\'u}a}, Omar
		and Mondrag{\'o}n, Jaime D.
	},
	year         = {2015 May-Jun},
	journal      = {
		Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La
		Nutricion
	},
	volume       = 67,
	number       = 3,
	pages        = {140--157},
	issn         = {0034-8376},
	abstract     = {
		Cancer patients with spinal metastases are a diagnostic and treatment
		challenge for the clinician. This challenge must be addressed through a
		multidisciplinary, multimodal, and individualized management. The presence of
		tumor cells in bone metastases results in homeostatic disruption between bone
		formation and remodeling. Bone destruction is a late event in the formation
		of lytic bone metastasis, starting when tumor cells proliferate; this in turn
		activates osteoclasts, seen as trabecular destruction in imaging studies.
		There may be excessive bone destruction and increased bone formation, which
		produce blastic lesions. Bone scintigraphy is currently the most widely used
		diagnostic method and is considered as the reference test for the diagnosis
		of spinal bone metastasis. However, we believe that in the near future
		positron emission tomography associated to computed tomography with 18F-NaF,
		or magnetic resonance using diffusion-weighted whole-body imaging with
		background body signal suppression, will replace bone scintigraphy due to
		their improved diagnostic accuracy. These new diagnostic tools will help
		prevent bone metastasis complications such as: intractable pain; spinal cord
		or cauda equina compression; hypercalcemia; pathological fractures; and
		spinal instability. With regards to the treatment, it can be uni- or
		multimodal, depending on the type and number of bone metastases. Among the
		types of treatment available for bone metastasis are chemotherapy,
		radiotherapy, and invasive procedures. The prognosis of patient survival
		depends on the histopathology of the primary tumor, the presence of bone
		metastasis, and the presence of neurological deficits.
	},
	langid       = {english},
	pmid         = 26202738
}

{"_id":"uBEaqAJWs2Xihpuvn","bibbaseid":"barragncampos-jimnezzaraza-mondragn-diagnosisandtreatmentoptionsofspinalmetastases-2015mayjun","author_short":["Barragán-Campos, H. M.","Jiménez-Zarazúa, O.","Mondragón, J. D."],"bibdata":{"bibtype":"article","type":"article","title":"Diagnosis and Treatment Options of Spinal Metastases","author":[{"propositions":[],"lastnames":["Barragán-Campos"],"firstnames":["Héctor","Manuel"],"suffixes":[]},{"propositions":[],"lastnames":["Jiménez-Zarazúa"],"firstnames":["Omar"],"suffixes":[]},{"propositions":[],"lastnames":["Mondragón"],"firstnames":["Jaime","D."],"suffixes":[]}],"year":"2015 May-Jun","journal":"Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion ","volume":"67","number":"3","pages":"140–157","issn":"0034-8376","abstract":"Cancer patients with spinal metastases are a diagnostic and treatment challenge for the clinician. This challenge must be addressed through a multidisciplinary, multimodal, and individualized management. The presence of tumor cells in bone metastases results in homeostatic disruption between bone formation and remodeling. Bone destruction is a late event in the formation of lytic bone metastasis, starting when tumor cells proliferate; this in turn activates osteoclasts, seen as trabecular destruction in imaging studies. There may be excessive bone destruction and increased bone formation, which produce blastic lesions. Bone scintigraphy is currently the most widely used diagnostic method and is considered as the reference test for the diagnosis of spinal bone metastasis. However, we believe that in the near future positron emission tomography associated to computed tomography with 18F-NaF, or magnetic resonance using diffusion-weighted whole-body imaging with background body signal suppression, will replace bone scintigraphy due to their improved diagnostic accuracy. These new diagnostic tools will help prevent bone metastasis complications such as: intractable pain; spinal cord or cauda equina compression; hypercalcemia; pathological fractures; and spinal instability. With regards to the treatment, it can be uni- or multimodal, depending on the type and number of bone metastases. Among the types of treatment available for bone metastasis are chemotherapy, radiotherapy, and invasive procedures. The prognosis of patient survival depends on the histopathology of the primary tumor, the presence of bone metastasis, and the presence of neurological deficits. ","langid":"english","pmid":"26202738","bibtex":"@article{barragn-campos2015diagnosis,\n\ttitle = {Diagnosis and {{Treatment Options}} of {{Spinal Metastases}}},\n\tauthor = {\n\t\t{Barrag{\\'a}n-Campos}, H{\\'e}ctor Manuel and {Jim{\\'e}nez-Zaraz{\\'u}a}, Omar\n\t\tand Mondrag{\\'o}n, Jaime D.\n\t},\n\tyear = {2015 May-Jun},\n\tjournal = {\n\t\tRevista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La\n\t\tNutricion\n\t},\n\tvolume = 67,\n\tnumber = 3,\n\tpages = {140--157},\n\tissn = {0034-8376},\n\tabstract = {\n\t\tCancer patients with spinal metastases are a diagnostic and treatment\n\t\tchallenge for the clinician. This challenge must be addressed through a\n\t\tmultidisciplinary, multimodal, and individualized management. The presence of\n\t\ttumor cells in bone metastases results in homeostatic disruption between bone\n\t\tformation and remodeling. Bone destruction is a late event in the formation\n\t\tof lytic bone metastasis, starting when tumor cells proliferate; this in turn\n\t\tactivates osteoclasts, seen as trabecular destruction in imaging studies.\n\t\tThere may be excessive bone destruction and increased bone formation, which\n\t\tproduce blastic lesions. Bone scintigraphy is currently the most widely used\n\t\tdiagnostic method and is considered as the reference test for the diagnosis\n\t\tof spinal bone metastasis. However, we believe that in the near future\n\t\tpositron emission tomography associated to computed tomography with 18F-NaF,\n\t\tor magnetic resonance using diffusion-weighted whole-body imaging with\n\t\tbackground body signal suppression, will replace bone scintigraphy due to\n\t\ttheir improved diagnostic accuracy. These new diagnostic tools will help\n\t\tprevent bone metastasis complications such as: intractable pain; spinal cord\n\t\tor cauda equina compression; hypercalcemia; pathological fractures; and\n\t\tspinal instability. With regards to the treatment, it can be uni- or\n\t\tmultimodal, depending on the type and number of bone metastases. Among the\n\t\ttypes of treatment available for bone metastasis are chemotherapy,\n\t\tradiotherapy, and invasive procedures. The prognosis of patient survival\n\t\tdepends on the histopathology of the primary tumor, the presence of bone\n\t\tmetastasis, and the presence of neurological deficits.\n\t},\n\tlangid = {english},\n\tpmid = 26202738\n}\n\n","author_short":["Barragán-Campos, H. M.","Jiménez-Zarazúa, O.","Mondragón, J. D."],"key":"barragn-campos2015diagnosis","id":"barragn-campos2015diagnosis","bibbaseid":"barragncampos-jimnezzaraza-mondragn-diagnosisandtreatmentoptionsofspinalmetastases-2015mayjun","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/FJu9aY3gewtT3hviu/lanirem_full_11nov2024.bib","dataSources":["vttjohQFa52E9tZec","XXCbbsL9GwntDLyo4","9HGwAkj7nkKD4NTi8","vvw9uBnyyiJkNw5Go","YsuwejyCppHFBdLLt","ypmczhtK9hg66BTKi","hhmXucDThMMZXRa2R"],"keywords":[],"search_terms":["diagnosis","treatment","options","spinal","metastases","barragán-campos","jiménez-zarazúa","mondragón"],"title":"Diagnosis and Treatment Options of Spinal Metastases","year":2015}