@TECHREPORT{arxiv_barton_sontag_1210_3809,
   AUTHOR       = {J. Barton and E.D. Sontag},
   INSTITUTION  = {http://arxiv.org/abs/1210.3809},
   TITLE        = {The energy costs of biological insulators},
   YEAR         = {2012},
   OPTADDRESS   = {},
   MONTH        = {October},
   OPTNOTE      = {},
   OPTNUMBER    = {},
   OPTTYPE      = {},
   KEYWORDS     = {retroactivity, systems biology, biochemical networks, 
      futile cycles, singular perturbations, modularity},
   ABSTRACT     = {Biochemical signaling pathways can be insulated from 
      impedance and competition effects through enzymatic "futile cycles" 
      which consume energy, typically in the form of ATP. We hypothesize 
      that better insulation necessarily requires higher energy 
      consumption, and provide evidence, through the computational analysis 
      of a simplified physical model, to support this hypothesis.}
}

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