Novel West Nile virus lineage 1a full genome sequences from human cases of infection in north-eastern Italy, 2011. Barzon, L., Pacenti, M., Franchin, E., Squarzon, L., Lavezzo, E., Toppo, S., Martello, T., Cattai, M., Cusinato, R., & Palu, G. Clinical Microbiology and Infection, 18(12):E541-E544, 2012.
Novel West Nile virus lineage 1a full genome sequences from human cases of infection in north-eastern Italy, 2011 [link]Paper  doi  abstract   bibtex   
During 20082009, several human cases of WNV disease caused by an endemic lineage 1a strain were reported in areas surrounding the Po river in north-eastern Italy. Since 2010, cases have been recorded in nearby northern areas, where, in 2011, both lineage 1a and 2 were detected. We describe here two new WNV complete genome sequences from human cases of WNV infection occurring in 2011 in the Veneto Region. Phylogenetic analysis showed that both genome sequences belonged to lineage 1a and were related to WNV strains of the Western Mediterranean subtype. The novel WNV genomes had high nucleotide and amino acid sequence divergence from each other and from the WNV strain circulating in Italy in 20082009. The presence of different WNV strains in a relatively small geographical area is a novel finding with unpredictable impact on human disease that requires further investigation.
@article{ ref9,
  author = {Barzon, L. and Pacenti, M. and Franchin, E. and Squarzon, L. and Lavezzo, E. and Toppo, S. and Martello, T. and Cattai, M. and Cusinato, R. and Palu, G.},
  title = {Novel West Nile virus lineage 1a full genome sequences from human cases of infection in north-eastern Italy, 2011},
  journal = {Clinical Microbiology and Infection},
  volume = {18},
  number = {12},
  pages = {E541-E544},
  abstract = {During 20082009, several human cases of WNV disease caused by an endemic lineage 1a strain were reported in areas surrounding the Po river in north-eastern Italy. Since 2010, cases have been recorded in nearby northern areas, where, in 2011, both lineage 1a and 2 were detected. We describe here two new WNV complete genome sequences from human cases of WNV infection occurring in 2011 in the Veneto Region. Phylogenetic analysis showed that both genome sequences belonged to lineage 1a and were related to WNV strains of the Western Mediterranean subtype. The novel WNV genomes had high nucleotide and amino acid sequence divergence from each other and from the WNV strain circulating in Italy in 20082009. The presence of different WNV strains in a relatively small geographical area is a novel finding with unpredictable impact on human disease that requires further investigation.},
  keywords = {disease outbreak
epidemiology
genome
phylogeny
west nile virus},
  year = {2012},
  doi = {DOI:10.1111/1469-0691.12001},
  url = {<Go to ISI>://000311109100009}
}

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