Escherichia Coli Meningitis Features in 325 Children From 2001 to 2013 in France. Basmaci, R., Bonacorsi, S., Bidet, P., Biran, V., Aujard, Y., Bingen, E., Béchet, S., Cohen, R., & Levy, C. Clinical Infectious Diseases, 61(5):779–786, September, 2015. ![Escherichia Coli Meningitis Features in 325 Children From 2001 to 2013 in France [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background. We aimed to describe features of Escherichia coli meningitis in a large population of children and the molecular characteristics of the involved strains to determine factors associated with severe disease or death. Methods. Between 2001 and 2013, a prospective national survey collected data for 325 children hospitalized with E. coli meningitis. The national reference center genetically characterized 141 isolates. Results. Among the 325 cases, 65.2% were term, 22.4% late preterm, and 12.5% very/extremely preterm infants. Escherichia coli meningitis was 7-fold more frequent in preterm than term infants. Median age at diagnosis was 14 days; 71.1% of infants were neonates, with 2 peaks of infection at age 0–3 days (mostly preterm neonates) and 11–15 days (mostly term neonates); 8.9% were \textgreater89 days old. In total, 51.1% patients were considered to have severe disease, and 9.2% died. B2.1 phylogenetic subgroup (56%) and O1 serogroup (27.7%) were the most frequently identified. On multivariate analysis, death was associated with preterm birth (odds ratio [OR], 3.3 [95% confidence interval \CI\, 1.3–8.4], P = .015 for late preterm infants; OR, 7.3 [95% CI, 2.7–20.9], P \textless .001 for very/extremely preterm infants) and cerebrospinal fluid (CSF) to blood glucose ratio \textless0.10 (OR, 15.3 [95% CI, 1.8–128.3], P = .012). Death was associated with uncommon O serogroup strains (P = .014) and severe disease with O7 serogroup (P = .034) and PapGII adhesin (OR, 2.3 [95% CI, 1.2–4.5], P = .015). Conclusions. In this large study of 325 cases of E. coli meningitis, risk factors of severe disease or death were preterm birth, severe hypoglycorrhachia, CSF/blood glucose ratio \textless0.10, and molecular characteristics of strains, which should help optimize therapeutic management.
@article{basmaci_escherichia_2015,
title = {Escherichia {Coli} {Meningitis} {Features} in 325 {Children} {From} 2001 to 2013 in {France}},
volume = {61},
issn = {1058-4838, 1537-6591},
url = {http://cid.oxfordjournals.org/content/61/5/779},
doi = {10.1093/cid/civ367},
abstract = {Background. We aimed to describe features of Escherichia coli meningitis in a large population of children and the molecular characteristics of the involved strains to determine factors associated with severe disease or death.
Methods. Between 2001 and 2013, a prospective national survey collected data for 325 children hospitalized with E. coli meningitis. The national reference center genetically characterized 141 isolates.
Results. Among the 325 cases, 65.2\% were term, 22.4\% late preterm, and 12.5\% very/extremely preterm infants. Escherichia coli meningitis was 7-fold more frequent in preterm than term infants. Median age at diagnosis was 14 days; 71.1\% of infants were neonates, with 2 peaks of infection at age 0–3 days (mostly preterm neonates) and 11–15 days (mostly term neonates); 8.9\% were {\textgreater}89 days old. In total, 51.1\% patients were considered to have severe disease, and 9.2\% died. B2.1 phylogenetic subgroup (56\%) and O1 serogroup (27.7\%) were the most frequently identified. On multivariate analysis, death was associated with preterm birth (odds ratio [OR], 3.3 [95\% confidence interval \{CI\}, 1.3–8.4], P = .015 for late preterm infants; OR, 7.3 [95\% CI, 2.7–20.9], P {\textless} .001 for very/extremely preterm infants) and cerebrospinal fluid (CSF) to blood glucose ratio {\textless}0.10 (OR, 15.3 [95\% CI, 1.8–128.3], P = .012). Death was associated with uncommon O serogroup strains (P = .014) and severe disease with O7 serogroup (P = .034) and PapGII adhesin (OR, 2.3 [95\% CI, 1.2–4.5], P = .015).
Conclusions. In this large study of 325 cases of E. coli meningitis, risk factors of severe disease or death were preterm birth, severe hypoglycorrhachia, CSF/blood glucose ratio {\textless}0.10, and molecular characteristics of strains, which should help optimize therapeutic management.},
language = {en},
number = {5},
urldate = {2015-11-16},
journal = {Clinical Infectious Diseases},
author = {Basmaci, Romain and Bonacorsi, Stéphane and Bidet, Philippe and Biran, Valérie and Aujard, Yannick and Bingen, Edouard and Béchet, Stéphane and Cohen, Robert and Levy, Corinne},
month = sep,
year = {2015},
pmid = {25944342},
pages = {779--786},
}
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{"_id":"eDduBNaff5fZn3uGY","bibbaseid":"basmaci-bonacorsi-bidet-biran-aujard-bingen-bchet-cohen-etal-escherichiacolimeningitisfeaturesin325childrenfrom2001to2013infrance-2015","author_short":["Basmaci, R.","Bonacorsi, S.","Bidet, P.","Biran, V.","Aujard, Y.","Bingen, E.","Béchet, S.","Cohen, R.","Levy, C."],"bibdata":{"bibtype":"article","type":"article","title":"Escherichia Coli Meningitis Features in 325 Children From 2001 to 2013 in France","volume":"61","issn":"1058-4838, 1537-6591","url":"http://cid.oxfordjournals.org/content/61/5/779","doi":"10.1093/cid/civ367","abstract":"Background. We aimed to describe features of Escherichia coli meningitis in a large population of children and the molecular characteristics of the involved strains to determine factors associated with severe disease or death. Methods. Between 2001 and 2013, a prospective national survey collected data for 325 children hospitalized with E. coli meningitis. The national reference center genetically characterized 141 isolates. Results. Among the 325 cases, 65.2% were term, 22.4% late preterm, and 12.5% very/extremely preterm infants. Escherichia coli meningitis was 7-fold more frequent in preterm than term infants. Median age at diagnosis was 14 days; 71.1% of infants were neonates, with 2 peaks of infection at age 0–3 days (mostly preterm neonates) and 11–15 days (mostly term neonates); 8.9% were \\textgreater89 days old. In total, 51.1% patients were considered to have severe disease, and 9.2% died. B2.1 phylogenetic subgroup (56%) and O1 serogroup (27.7%) were the most frequently identified. On multivariate analysis, death was associated with preterm birth (odds ratio [OR], 3.3 [95% confidence interval \\CI\\, 1.3–8.4], P = .015 for late preterm infants; OR, 7.3 [95% CI, 2.7–20.9], P \\textless .001 for very/extremely preterm infants) and cerebrospinal fluid (CSF) to blood glucose ratio \\textless0.10 (OR, 15.3 [95% CI, 1.8–128.3], P = .012). Death was associated with uncommon O serogroup strains (P = .014) and severe disease with O7 serogroup (P = .034) and PapGII adhesin (OR, 2.3 [95% CI, 1.2–4.5], P = .015). Conclusions. In this large study of 325 cases of E. coli meningitis, risk factors of severe disease or death were preterm birth, severe hypoglycorrhachia, CSF/blood glucose ratio \\textless0.10, and molecular characteristics of strains, which should help optimize therapeutic management.","language":"en","number":"5","urldate":"2015-11-16","journal":"Clinical Infectious Diseases","author":[{"propositions":[],"lastnames":["Basmaci"],"firstnames":["Romain"],"suffixes":[]},{"propositions":[],"lastnames":["Bonacorsi"],"firstnames":["Stéphane"],"suffixes":[]},{"propositions":[],"lastnames":["Bidet"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Biran"],"firstnames":["Valérie"],"suffixes":[]},{"propositions":[],"lastnames":["Aujard"],"firstnames":["Yannick"],"suffixes":[]},{"propositions":[],"lastnames":["Bingen"],"firstnames":["Edouard"],"suffixes":[]},{"propositions":[],"lastnames":["Béchet"],"firstnames":["Stéphane"],"suffixes":[]},{"propositions":[],"lastnames":["Cohen"],"firstnames":["Robert"],"suffixes":[]},{"propositions":[],"lastnames":["Levy"],"firstnames":["Corinne"],"suffixes":[]}],"month":"September","year":"2015","pmid":"25944342","pages":"779–786","bibtex":"@article{basmaci_escherichia_2015,\n\ttitle = {Escherichia {Coli} {Meningitis} {Features} in 325 {Children} {From} 2001 to 2013 in {France}},\n\tvolume = {61},\n\tissn = {1058-4838, 1537-6591},\n\turl = {http://cid.oxfordjournals.org/content/61/5/779},\n\tdoi = {10.1093/cid/civ367},\n\tabstract = {Background. We aimed to describe features of Escherichia coli meningitis in a large population of children and the molecular characteristics of the involved strains to determine factors associated with severe disease or death.\nMethods. Between 2001 and 2013, a prospective national survey collected data for 325 children hospitalized with E. coli meningitis. The national reference center genetically characterized 141 isolates.\nResults. Among the 325 cases, 65.2\\% were term, 22.4\\% late preterm, and 12.5\\% very/extremely preterm infants. Escherichia coli meningitis was 7-fold more frequent in preterm than term infants. Median age at diagnosis was 14 days; 71.1\\% of infants were neonates, with 2 peaks of infection at age 0–3 days (mostly preterm neonates) and 11–15 days (mostly term neonates); 8.9\\% were {\\textgreater}89 days old. In total, 51.1\\% patients were considered to have severe disease, and 9.2\\% died. B2.1 phylogenetic subgroup (56\\%) and O1 serogroup (27.7\\%) were the most frequently identified. On multivariate analysis, death was associated with preterm birth (odds ratio [OR], 3.3 [95\\% confidence interval \\{CI\\}, 1.3–8.4], P = .015 for late preterm infants; OR, 7.3 [95\\% CI, 2.7–20.9], P {\\textless} .001 for very/extremely preterm infants) and cerebrospinal fluid (CSF) to blood glucose ratio {\\textless}0.10 (OR, 15.3 [95\\% CI, 1.8–128.3], P = .012). Death was associated with uncommon O serogroup strains (P = .014) and severe disease with O7 serogroup (P = .034) and PapGII adhesin (OR, 2.3 [95\\% CI, 1.2–4.5], P = .015).\nConclusions. In this large study of 325 cases of E. coli meningitis, risk factors of severe disease or death were preterm birth, severe hypoglycorrhachia, CSF/blood glucose ratio {\\textless}0.10, and molecular characteristics of strains, which should help optimize therapeutic management.},\n\tlanguage = {en},\n\tnumber = {5},\n\turldate = {2015-11-16},\n\tjournal = {Clinical Infectious Diseases},\n\tauthor = {Basmaci, Romain and Bonacorsi, Stéphane and Bidet, Philippe and Biran, Valérie and Aujard, Yannick and Bingen, Edouard and Béchet, Stéphane and Cohen, Robert and Levy, Corinne},\n\tmonth = sep,\n\tyear = {2015},\n\tpmid = {25944342},\n\tpages = {779--786},\n}\n\n","author_short":["Basmaci, R.","Bonacorsi, S.","Bidet, P.","Biran, V.","Aujard, Y.","Bingen, E.","Béchet, S.","Cohen, R.","Levy, C."],"key":"basmaci_escherichia_2015","id":"basmaci_escherichia_2015","bibbaseid":"basmaci-bonacorsi-bidet-biran-aujard-bingen-bchet-cohen-etal-escherichiacolimeningitisfeaturesin325childrenfrom2001to2013infrance-2015","role":"author","urls":{"Paper":"http://cid.oxfordjournals.org/content/61/5/779"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":[],"search_terms":["escherichia","coli","meningitis","features","325","children","2001","2013","france","basmaci","bonacorsi","bidet","biran","aujard","bingen","béchet","cohen","levy"],"title":"Escherichia Coli Meningitis Features in 325 Children From 2001 to 2013 in France","year":2015}