Predicting growth and mortality of bivalve larvae using gene expression and supervised machine learning. Bassim, S., Chapman, R. W., Tanguy, A., Moraga, D., & Tremblay, R. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 16:59--72, 2015. ![Predicting growth and mortality of bivalve larvae using gene expression and supervised machine learning [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex It is commonly known that the nature of the diet has diverse consequences on larval performance and longevity, however it is still unclear which genes have critical impacts on bivalve development and which pathways are of particular importance in their vulnerability or resistance. First we show that a diet deficient in essential fatty acid (EFA) produces higher larval mortality rates, a reduced shell growth, and lower postlarval performance, all of which are positively correlated with a decline in arachidonic and eicosapentaenoic acids levels, two EFAs known as eicosanoid precursors. Eicosanoids affect the cell inflammatory reactions and are synthesized from long-chain EFAs. Second, we show for the first time that a deficiency in eicosanoid precursors is associated with a network of 29 genes. Their differential regulation can lead to slower growth and higher mortality of Mytilus edulis larvae. Some of these genes are specific to bivalves and others are implicated at the same time in lipid metabolism and defense. Several genes are expressed only during pre-metamorphosis where they are essential for muscle or neurone development and biomineralization, but only in stress-induced larvae. Finally, we discuss how our networks of differentially expressed genes might dynamically alter the development of marine bivalves, especially under dietary influence.
@article{bassim_predicting_2015,
title = {Predicting growth and mortality of bivalve larvae using gene expression and supervised machine learning},
volume = {16},
issn = {1744-117X},
url = {http://www.sciencedirect.com/science/article/pii/S1744117X15000520},
doi = {10.1016/j.cbd.2015.07.004},
abstract = {It is commonly known that the nature of the diet has diverse consequences on larval performance and longevity, however it is still unclear which genes have critical impacts on bivalve development and which pathways are of particular importance in their vulnerability or resistance. First we show that a diet deficient in essential fatty acid (EFA) produces higher larval mortality rates, a reduced shell growth, and lower postlarval performance, all of which are positively correlated with a decline in arachidonic and eicosapentaenoic acids levels, two EFAs known as eicosanoid precursors. Eicosanoids affect the cell inflammatory reactions and are synthesized from long-chain EFAs. Second, we show for the first time that a deficiency in eicosanoid precursors is associated with a network of 29 genes. Their differential regulation can lead to slower growth and higher mortality of Mytilus edulis larvae. Some of these genes are specific to bivalves and others are implicated at the same time in lipid metabolism and defense. Several genes are expressed only during pre-metamorphosis where they are essential for muscle or neurone development and biomineralization, but only in stress-induced larvae. Finally, we discuss how our networks of differentially expressed genes might dynamically alter the development of marine bivalves, especially under dietary influence.},
urldate = {2015-08-24TZ},
journal = {Comparative Biochemistry and Physiology Part D: Genomics and Proteomics},
author = {Bassim, Sleiman and Chapman, Robert W. and Tanguy, Arnaud and Moraga, Dario and Tremblay, Rejean},
year = {2015},
keywords = {ACL, Development, E1, Eicosanoids, Microarray, RNA-seq, fatty acids},
pages = {59--72}
}
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