gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase. Baud, S., Bellec, Y., Miquel, M., Bellini, C., Caboche, M., Lepiniec, L., Faure, J., & Rochat, C. EMBO reports, 5(5):515–520, May, 2004. Publisher: John Wiley & Sons, Ltd![gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Normal embryo development is required for correct seedling formation. The Arabidopsis gurke and pasticcino3 mutants were isolated from different developmental screens and the corresponding embryos exhibit severe defects in their apical region, affecting bilateral symmetry. We have recently identified lethal acc1 mutants affected in acetyl-CoA carboxylase 1 (ACCase 1) that display a similar embryo phenotype. A series of crosses showed that gk and pas3 are allelic to acc1 mutants, and direct sequencing of the ACC1 gene revealed point mutations in these new alleles. The isolation of leaky acc1 alleles demonstrated that ACCase 1 is essential for correct plant development and that mutations in ACCase affect cellular division in plants, as is the case in yeast. Interestingly, significant metabolic complementation of the mutant phenotype was obtained by exogenous supply of malonate, suggesting that the lack of cytosolic malonyl-CoA is likely to be the initial factor leading to abnormal development in the acc1 mutants.
@article{baud_gurke_2004,
title = {gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-{CoA} carboxylase},
volume = {5},
issn = {1469-221X},
url = {https://www.embopress.org/doi/full/10.1038/sj.embor.7400124},
doi = {10.1038/sj.embor.7400124},
abstract = {Normal embryo development is required for correct seedling formation. The Arabidopsis gurke and pasticcino3 mutants were isolated from different developmental screens and the corresponding embryos exhibit severe defects in their apical region, affecting bilateral symmetry. We have recently identified lethal acc1 mutants affected in acetyl-CoA carboxylase 1 (ACCase 1) that display a similar embryo phenotype. A series of crosses showed that gk and pas3 are allelic to acc1 mutants, and direct sequencing of the ACC1 gene revealed point mutations in these new alleles. The isolation of leaky acc1 alleles demonstrated that ACCase 1 is essential for correct plant development and that mutations in ACCase affect cellular division in plants, as is the case in yeast. Interestingly, significant metabolic complementation of the mutant phenotype was obtained by exogenous supply of malonate, suggesting that the lack of cytosolic malonyl-CoA is likely to be the initial factor leading to abnormal development in the acc1 mutants.},
number = {5},
urldate = {2021-06-30},
journal = {EMBO reports},
author = {Baud, Sébastien and Bellec, Yannick and Miquel, Martine and Bellini, Catherine and Caboche, Michel and Lepiniec, Loïc and Faure, Jean-Denis and Rochat, Christine},
month = may,
year = {2004},
note = {Publisher: John Wiley \& Sons, Ltd},
keywords = {cell division, embryo development, plant development, very-long-chain fatty acids},
pages = {515--520},
}
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