Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBPbeta. Baus-Loncar, M., Al-azzeh, E., Romanska, H., Lalani, E., Stamp, G. W H, Blin, N., & Kayademir, T. Peptides, 25(5):849–854, May, 2004. ![Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBPbeta [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The acute phase response is strictly connected with modulation of gene expression. Transcriptional control of many genes is mediated by binding of diverse transcription factors to cis-acting DNA motifs in the respective promoter sequence. We now describe such regulatory elements for the TFF3 gene coding for a peptide involved in response to gut irritation. TNF-alpha stimulation, which induces NF-kappaB activation, evoked up to 10-fold reduction of TFF3 expression in the colon tumour cell line HT-29. Several consensus binding sites for members of the NF-kappaB transcription factor subunits are located in the 5'-flanking region of TFF3. Mutating these sites was aimed at discovering which one is responsible for NF-kappaB binding and thus regulation of TFF3 expression.
@article{baus-loncar_transcriptional_2004,
title = {Transcriptional control of {TFF3} (intestinal trefoil factor) via promoter binding sites for the nuclear factor {kappaB} and {C}/{EBPbeta}},
volume = {25},
issn = {0196-9781},
url = {http://www.ncbi.nlm.nih.gov.ezproxy1.library.arizona.edu/pubmed/15177881},
doi = {10.1016/j.peptides.2003.11.019},
abstract = {The acute phase response is strictly connected with modulation of gene expression. Transcriptional control of many genes is mediated by binding of diverse transcription factors to cis-acting DNA motifs in the respective promoter sequence. We now describe such regulatory elements for the TFF3 gene coding for a peptide involved in response to gut irritation. TNF-alpha stimulation, which induces NF-kappaB activation, evoked up to 10-fold reduction of TFF3 expression in the colon tumour cell line HT-29. Several consensus binding sites for members of the NF-kappaB transcription factor subunits are located in the 5'-flanking region of TFF3. Mutating these sites was aimed at discovering which one is responsible for NF-kappaB binding and thus regulation of TFF3 expression.},
number = {5},
urldate = {2011-01-07},
journal = {Peptides},
author = {Baus-Loncar, Mirela and Al-azzeh, Ezzal-din and Romanska, Hanna and Lalani, El-Nasir and Stamp, Gordon W H and Blin, Nikolaus and Kayademir, Tuncay},
month = may,
year = {2004},
pmid = {15177881},
keywords = {CCAAT-Enhancer-Binding Proteins, Electrophoretic Mobility Shift Assay, HT29 Cells, Humans, Mucins, Muscle Proteins, Mutation, NF-kappa B, NWG, Peptides, Promoter Regions, Genetic, Transcription Factor RelA, Transcription Factors, Transcriptional Activation, Tumor Necrosis Factor-alpha},
pages = {849--854},
}
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