An amyloid organelle, solid-state NMR evidence for cross-$β$ assembly of gas vesicles. Bayro, M. J, Daviso, E., Belenky, M., Griffin, R. G, & Herzfeld, J. The Journal of biological chemistry, 287(5):3479–3484, January, 2012. ![An amyloid organelle, solid-state NMR evidence for cross-$β$ assembly of gas vesicles. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Functional amyloids have been identified in a wide range of organisms, taking on a variety of biological roles and being controlled by remarkable mechanisms of directed assembly. Here, we report that amyloid fibrils constitute the ribs of the buoyancy organelles of Anabaena flos-aquae. The walls of these gas-filled vesicles are known to comprise a single protein, GvpA, arranged in a low pitch helix. However, the tertiary and quaternary structures have been elusive. Using solid-state NMR correlation spectroscopy we find detailed evidence for an extended cross-$β$ structure. This amyloid assembly helps to account for the strength and amphiphilic properties of the vesicle wall. Buoyancy organelles thus dramatically extend the scope of known functional amyloids.
@article{Bayro2012,
title = {An amyloid organelle, solid-state {NMR} evidence for cross-\$β\$ assembly of gas vesicles.},
volume = {287},
issn = {1083-351X},
url = {http://www.jbc.org/search?author1=&fulltext=&pubdate_year=&volume=287&firstpage=3479&submit=yes},
doi = {10.1074/jbc.M111.313049},
abstract = {Functional amyloids have been identified in a wide range of organisms, taking on a variety of biological roles and being controlled by remarkable mechanisms of directed assembly. Here, we report that amyloid fibrils constitute the ribs of the buoyancy organelles of Anabaena flos-aquae. The walls of these gas-filled vesicles are known to comprise a single protein, GvpA, arranged in a low pitch helix. However, the tertiary and quaternary structures have been elusive. Using solid-state NMR correlation spectroscopy we find detailed evidence for an extended cross-\$β\$ structure. This amyloid assembly helps to account for the strength and amphiphilic properties of the vesicle wall. Buoyancy organelles thus dramatically extend the scope of known functional amyloids.},
number = {5},
journal = {The Journal of biological chemistry},
author = {Bayro, Marvin J and Daviso, Eugenio and Belenky, Marina and Griffin, Robert G and Herzfeld, Judith},
month = jan,
year = {2012},
pmid = {22147705},
keywords = {\#nosource, Amyloid, Amyloid: chemistry, Amyloid: metabolism, Anabaena flos-aquae, Anabaena flos-aquae: chemistry, Anabaena flos-aquae: metabolism, Biomolecular, Nuclear Magnetic Resonance, Organelles, Organelles: chemistry, Organelles: metabolism, Protein Structure, Proteins, Proteins: chemistry, Proteins: metabolism, Secondary},
pages = {3479--3484},
}
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