@article{bazelier_risk_2012,
	title = {Risk of cataract and glaucoma in patients with multiple sclerosis},
	volume = {18},
	issn = {1477-0970},
	doi = {10.1177/1352458511426737},
	abstract = {BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.
METHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.
RESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95\% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95\% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95\% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95\% CI 1.01-2.86)) was significantly greater in patients {\textless} 50 years, particularly in men {\textless} 50 years: cataract, adj. HR 4.23 (95\% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95\% CI 1.28-5.93).
CONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.},
	language = {eng},
	number = {5},
	journal = {Multiple Sclerosis (Houndmills, Basingstoke, England)},
	author = {Bazelier, Marloes T. and Mueller-Schotte, Sigrid and Leufkens, Hubert G. M. and Uitdehaag, Bernard M. J. and van Staa, Tjeerd and de Vries, Frank},
	month = may,
	year = {2012},
	pmid = {22025330},
	keywords = {Adolescent, Adult, Age Factors, Case-Control Studies, Cataract, Disease-Free Survival, England, Female, Glaucoma, Glucocorticoids, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multiple Sclerosis, Proportional Hazards Models, Registries, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Young Adult, incidence},
	pages = {628--638}
}

{"_id":"SiXe57TyTmHyjiZYj","bibbaseid":"bazelier-muellerschotte-leufkens-uitdehaag-vanstaa-devries-riskofcataractandglaucomainpatientswithmultiplesclerosis-2012","downloads":0,"creationDate":"2017-08-15T09:38:10.204Z","title":"Risk of cataract and glaucoma in patients with multiple sclerosis","author_short":["Bazelier, M. T.","Mueller-Schotte, S.","Leufkens, H. G. M.","Uitdehaag, B. M. J.","van Staa, T.","de Vries, F."],"year":2012,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"Risk of cataract and glaucoma in patients with multiple sclerosis","volume":"18","issn":"1477-0970","doi":"10.1177/1352458511426737","abstract":"BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma. METHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use. RESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95% CI 1.01-2.86)) was significantly greater in patients \\textless 50 years, particularly in men \\textless 50 years: cataract, adj. HR 4.23 (95% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95% CI 1.28-5.93). CONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.","language":"eng","number":"5","journal":"Multiple Sclerosis (Houndmills, Basingstoke, England)","author":[{"propositions":[],"lastnames":["Bazelier"],"firstnames":["Marloes","T."],"suffixes":[]},{"propositions":[],"lastnames":["Mueller-Schotte"],"firstnames":["Sigrid"],"suffixes":[]},{"propositions":[],"lastnames":["Leufkens"],"firstnames":["Hubert","G.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Uitdehaag"],"firstnames":["Bernard","M.","J."],"suffixes":[]},{"propositions":["van"],"lastnames":["Staa"],"firstnames":["Tjeerd"],"suffixes":[]},{"propositions":["de"],"lastnames":["Vries"],"firstnames":["Frank"],"suffixes":[]}],"month":"May","year":"2012","pmid":"22025330","keywords":"Adolescent, Adult, Age Factors, Case-Control Studies, Cataract, Disease-Free Survival, England, Female, Glaucoma, Glucocorticoids, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multiple Sclerosis, Proportional Hazards Models, Registries, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Young Adult, incidence","pages":"628--638","bibtex":"@article{bazelier_risk_2012,\n\ttitle = {Risk of cataract and glaucoma in patients with multiple sclerosis},\n\tvolume = {18},\n\tissn = {1477-0970},\n\tdoi = {10.1177/1352458511426737},\n\tabstract = {BACKGROUND: The aim of the study was to evaluate whether multiple sclerosis (MS) is associated with risk of cataract or glaucoma.\nMETHODS: We conducted a population-based cohort study utilizing the UK General Practice Research Database (1987-2009) linked to the national hospital registry of England (1997-2008). Incident MS patients (5576 cases) were identified and each was matched to six patients without MS (controls) by age, gender, and practice. Cox proportional hazard models were used to estimate hazard ratios (HRs) of incident cataract and glaucoma in MS. Time-dependent adjustments were made for age, history of diseases and drug use.\nRESULTS: MS patients had no overall increased risk of cataract, adjusted (adj.) HR 1.15 (95\\% CI 0.94-1.41) or glaucoma, adj. HR 1.02 (95\\% CI 0.78-1.33). Risk of cataract (adj. HR 2.45 (95\\% CI 1.56-3.86)) and glaucoma (adj. HR 1.70 (95\\% CI 1.01-2.86)) was significantly greater in patients {\\textless} 50 years, particularly in men {\\textless} 50 years: cataract, adj. HR 4.23 (95\\% CI 2.22-8.05) and glaucoma, adj. HR 2.76 (95\\% CI 1.28-5.93).\nCONCLUSION: This is the first study which showed that the risk of cataract and glaucoma is elevated in MS patients younger than 50 years, particularly men.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Multiple Sclerosis (Houndmills, Basingstoke, England)},\n\tauthor = {Bazelier, Marloes T. and Mueller-Schotte, Sigrid and Leufkens, Hubert G. M. and Uitdehaag, Bernard M. J. and van Staa, Tjeerd and de Vries, Frank},\n\tmonth = may,\n\tyear = {2012},\n\tpmid = {22025330},\n\tkeywords = {Adolescent, Adult, Age Factors, Case-Control Studies, Cataract, Disease-Free Survival, England, Female, Glaucoma, Glucocorticoids, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multiple Sclerosis, Proportional Hazards Models, Registries, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Young Adult, incidence},\n\tpages = {628--638}\n}\n\n","author_short":["Bazelier, M. T.","Mueller-Schotte, S.","Leufkens, H. G. M.","Uitdehaag, B. M. 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