Learning Contextual Hierarchical Structure of Medical Concepts with Poincairé Embeddings to Clarify Phenotypes. Beaulieu-Jones, B. K, Kohane, I. S, & Beam, A. L In PSB, pages 8–17, 2019.
Learning Contextual Hierarchical Structure of Medical Concepts with Poincairé Embeddings to Clarify Phenotypes. [link]Paper  abstract   bibtex   11 downloads  
Biomedical association studies are increasingly done using clinical concepts, and in particular diagnostic codes from clinical data repositories as phenotypes. Clinical concepts can be represented in a meaningful, vector space using word embedding models. These embeddings allow for comparison between clinical concepts or for straightforward input to machine learning models. Using traditional approaches, good representations require high dimensionality, making downstream tasks such as visualization more difficult. We applied PoincarÈ embeddings in a 2-dimensional hyperbolic space to a large-scale administrative claims database and show performance comparable to 100-dimensional embeddings in a euclidean space. We then examine disease relationships under different disease contexts to better understand potential phenotypes.
@inproceedings{beaulieu2019learning,
  title={Learning Contextual Hierarchical Structure of Medical Concepts with Poincair{\'e} Embeddings to Clarify Phenotypes.},
  author={Beaulieu-Jones, Brett K and Kohane, Isaac S and Beam, Andrew L},
  booktitle={PSB},
  pages={8--17},
  keywords={Distributed Representations},
  abstract={Biomedical association studies are increasingly done using clinical concepts, and in particular diagnostic codes from clinical data repositories as phenotypes. Clinical concepts can be represented in a meaningful, vector space using word embedding models. These embeddings allow for comparison between clinical concepts or for straightforward input to machine learning models. Using traditional approaches, good representations require high dimensionality, making downstream tasks such as visualization more difficult. We applied PoincarÈ embeddings in a 2-dimensional hyperbolic space to a large-scale administrative claims database and show performance comparable to 100-dimensional embeddings in a euclidean space. We then examine disease relationships under different disease contexts to better understand potential phenotypes.},
  url_Paper={https://www.dropbox.com/s/1px56om4qr50yki/bbj_poincare_psb2019.pdf?dl=1},
  year={2019}
}

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