@article{RN111,
   author = {Beitel-White, N. and Aycock, K. N. and Manuchehrabadi, N. and Zhao, Y. and Imran, K. M. and Coutermarsh-Ott, S. and Allen, I. C. and Lorenzo, M. F. and Davalos, R. V.},
   title = {Properties of tissue within prostate tumors and treatment planning implications for ablation therapies},
   journal = {Annu Int Conf IEEE Eng Med Biol Soc},
   volume = {2021},
   pages = {1539-1542},
   note = {2694-0604
Beitel-White, Natalie
Aycock, Kenneth N
Manuchehrabadi, Navid
Zhao, Yajun
Imran, Khan Mohammad
Coutermarsh-Ott, Sheryl
Allen, Irving C
Lorenzo, Melvin F
Davalos, Rafael V
R01 CA240476/CA/NCI NIH HHS/United States
Journal Article
Research Support, Non-U.S. Gov't
United States
2021/12/12
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1539-1542. doi: 10.1109/EMBC46164.2021.9630534.},
   abstract = {Irreversible electroporation (IRE) is a promising alternative therapy for the local treatment of prostate tumors. The procedure involves the direct insertion of needle electrodes into the target zone, and subsequent delivery of short but high-voltage pulses. Successful outcomes rely on adequate exposure of the tumor to a threshold electrical field. To aid in predicting this exposure, computational models have been developed, yet often do not incorporate the appropriate tissue-specific properties. This work aims to quantify electrical conductivity behavior during IRE for three types of tissue present in the target area of a prostate cancer ablation: the tumor tissue itself, the surrounding healthy tissue, and potential areas of necrosis within the tumor. Animal tissues were used as a stand-in for primary samples. The patient-derived prostate tumor tissue showed very similar responses to healthy porcine prostate tissue. An examination of necrotic tissue inside the tumors revealed a large difference, however, and a computational model showed that a necrotic core with differing electrical properties can cause unexpected inhomogeneities within the treatment region.},
   keywords = {Animals
Electric Conductivity
Electrodes
*Electroporation
Humans
Male
Prostate/surgery
*Prostatic Neoplasms/therapy
Swine},
   ISSN = {2375-7477},
   DOI = {10.1109/embc46164.2021.9630534},
   year = {2021},
   type = {Journal Article}
}

{"_id":"MStQnMigooW8DFhWH","bibbaseid":"beitelwhite-aycock-manuchehrabadi-zhao-imran-coutermarshott-allen-lorenzo-etal-propertiesoftissuewithinprostatetumorsandtreatmentplanningimplicationsforablationtherapies-2021","author_short":["Beitel-White, N.","Aycock, K. N.","Manuchehrabadi, N.","Zhao, Y.","Imran, K. M.","Coutermarsh-Ott, S.","Allen, I. C.","Lorenzo, M. F.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Beitel-White"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Aycock"],"firstnames":["K.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Manuchehrabadi"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Imran"],"firstnames":["K.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Coutermarsh-Ott"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Allen"],"firstnames":["I.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Lorenzo"],"firstnames":["M.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Properties of tissue within prostate tumors and treatment planning implications for ablation therapies","journal":"Annu Int Conf IEEE Eng Med Biol Soc","volume":"2021","pages":"1539-1542","note":"2694-0604 Beitel-White, Natalie Aycock, Kenneth N Manuchehrabadi, Navid Zhao, Yajun Imran, Khan Mohammad Coutermarsh-Ott, Sheryl Allen, Irving C Lorenzo, Melvin F Davalos, Rafael V R01 CA240476/CA/NCI NIH HHS/United States Journal Article Research Support, Non-U.S. Gov't United States 2021/12/12 Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1539-1542. doi: 10.1109/EMBC46164.2021.9630534.","abstract":"Irreversible electroporation (IRE) is a promising alternative therapy for the local treatment of prostate tumors. The procedure involves the direct insertion of needle electrodes into the target zone, and subsequent delivery of short but high-voltage pulses. Successful outcomes rely on adequate exposure of the tumor to a threshold electrical field. To aid in predicting this exposure, computational models have been developed, yet often do not incorporate the appropriate tissue-specific properties. This work aims to quantify electrical conductivity behavior during IRE for three types of tissue present in the target area of a prostate cancer ablation: the tumor tissue itself, the surrounding healthy tissue, and potential areas of necrosis within the tumor. Animal tissues were used as a stand-in for primary samples. The patient-derived prostate tumor tissue showed very similar responses to healthy porcine prostate tissue. An examination of necrotic tissue inside the tumors revealed a large difference, however, and a computational model showed that a necrotic core with differing electrical properties can cause unexpected inhomogeneities within the treatment region.","keywords":"Animals Electric Conductivity Electrodes *Electroporation Humans Male Prostate/surgery *Prostatic Neoplasms/therapy Swine","issn":"2375-7477","doi":"10.1109/embc46164.2021.9630534","year":"2021","bibtex":"@article{RN111,\n author = {Beitel-White, N. and Aycock, K. N. and Manuchehrabadi, N. and Zhao, Y. and Imran, K. M. and Coutermarsh-Ott, S. and Allen, I. C. and Lorenzo, M. F. and Davalos, R. V.},\n title = {Properties of tissue within prostate tumors and treatment planning implications for ablation therapies},\n journal = {Annu Int Conf IEEE Eng Med Biol Soc},\n volume = {2021},\n pages = {1539-1542},\n note = {2694-0604\nBeitel-White, Natalie\nAycock, Kenneth N\nManuchehrabadi, Navid\nZhao, Yajun\nImran, Khan Mohammad\nCoutermarsh-Ott, Sheryl\nAllen, Irving C\nLorenzo, Melvin F\nDavalos, Rafael V\nR01 CA240476/CA/NCI NIH HHS/United States\nJournal Article\nResearch Support, Non-U.S. Gov't\nUnited States\n2021/12/12\nAnnu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1539-1542. doi: 10.1109/EMBC46164.2021.9630534.},\n abstract = {Irreversible electroporation (IRE) is a promising alternative therapy for the local treatment of prostate tumors. The procedure involves the direct insertion of needle electrodes into the target zone, and subsequent delivery of short but high-voltage pulses. Successful outcomes rely on adequate exposure of the tumor to a threshold electrical field. To aid in predicting this exposure, computational models have been developed, yet often do not incorporate the appropriate tissue-specific properties. This work aims to quantify electrical conductivity behavior during IRE for three types of tissue present in the target area of a prostate cancer ablation: the tumor tissue itself, the surrounding healthy tissue, and potential areas of necrosis within the tumor. Animal tissues were used as a stand-in for primary samples. The patient-derived prostate tumor tissue showed very similar responses to healthy porcine prostate tissue. An examination of necrotic tissue inside the tumors revealed a large difference, however, and a computational model showed that a necrotic core with differing electrical properties can cause unexpected inhomogeneities within the treatment region.},\n keywords = {Animals\nElectric Conductivity\nElectrodes\n*Electroporation\nHumans\nMale\nProstate/surgery\n*Prostatic Neoplasms/therapy\nSwine},\n ISSN = {2375-7477},\n DOI = {10.1109/embc46164.2021.9630534},\n year = {2021},\n type = {Journal Article}\n}\n\n","author_short":["Beitel-White, N.","Aycock, K. N.","Manuchehrabadi, N.","Zhao, Y.","Imran, K. M.","Coutermarsh-Ott, S.","Allen, I. C.","Lorenzo, M. F.","Davalos, R. V."],"key":"RN111","id":"RN111","bibbaseid":"beitelwhite-aycock-manuchehrabadi-zhao-imran-coutermarshott-allen-lorenzo-etal-propertiesoftissuewithinprostatetumorsandtreatmentplanningimplicationsforablationtherapies-2021","role":"author","urls":{},"keyword":["Animals Electric Conductivity Electrodes *Electroporation Humans Male Prostate/surgery *Prostatic Neoplasms/therapy Swine"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["animals electric conductivity electrodes *electroporation humans male prostate/surgery *prostatic neoplasms/therapy swine"],"search_terms":["properties","tissue","within","prostate","tumors","treatment","planning","implications","ablation","therapies","beitel-white","aycock","manuchehrabadi","zhao","imran","coutermarsh-ott","allen","lorenzo","davalos"],"title":"Properties of tissue within prostate tumors and treatment planning implications for ablation therapies","year":2021}