@article{RN129,
   author = {Beitel-White, N. and Lorenzo, M. F. and Zhao, Y. and Brock, R. M. and Coutermarsh-Ott, S. and Allen, I. C. and Manuchehrabadi, N. and Davalos, R. V.},
   title = {Multi-Tissue Analysis on the Impact of Electroporation on Electrical and Thermal Properties},
   journal = {IEEE Trans Biomed Eng},
   volume = {68},
   number = {3},
   pages = {771-782},
   note = {1558-2531
Beitel-White, Natalie
Lorenzo, Melvin F
Zhao, Yajun
Brock, Rebecca M
Coutermarsh-Ott, Sheryl
Allen, Irving C
Manuchehrabadi, Navid
Davalos, Rafael V
P01 CA207206/CA/NCI NIH HHS/United States
R01 CA240476/CA/NCI NIH HHS/United States
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
United States
2020/08/04
IEEE Trans Biomed Eng. 2021 Mar;68(3):771-782. doi: 10.1109/TBME.2020.3013572. Epub 2021 Feb 18.},
   abstract = {OBJECTIVE: Tissue electroporation is achieved by applying a series of electric pulses to destabilize cell membranes within the target tissue. The treatment volume is dictated by the electric field distribution, which depends on the pulse parameters and tissue type and can be readily predicted using numerical methods. These models require the relevant tissue properties to be known beforehand. This study aims to quantify electrical and thermal properties for three different tissue types relevant to current clinical electroporation. METHODS: Pancreatic, brain, and liver tissue were harvested from pigs, then treated with IRE pulses in a parallel-plate configuration. Resulting current and temperature readings were used to calculate the conductivity and its temperature dependence for each tissue type. Finally, a computational model was constructed to examine the impact of differences between tissue types. RESULTS: Baseline conductivity values (mean 0.11, 0.14, and 0.12 S/m) and temperature coefficients of conductivity (mean 2.0, 2.3, and 1.2 % per degree Celsius) were calculated for pancreas, brain, and liver, respectively. The accompanying computational models suggest field distribution and thermal damage volumes are dependent on tissue type. CONCLUSION: The three tissue types show similar electrical and thermal responses to IRE, though brain tissue exhibits the greatest differences. The results also show that tissue type plays a role in the expected ablation and thermal damage volumes. SIGNIFICANCE: The conductivity and its changes due to heating are expected to have a marked impact on the ablation volume. Incorporating these tissue properties aids in the prediction and optimization of electroporation-based therapies.},
   keywords = {Animals
Electric Conductivity
*Electricity
*Electroporation
Liver
Swine
Temperature},
   ISSN = {0018-9294 (Print)
0018-9294},
   DOI = {10.1109/tbme.2020.3013572},
   year = {2021},
   type = {Journal Article}
}

{"_id":"TBebRmJDg6T5t7mrR","bibbaseid":"beitelwhite-lorenzo-zhao-brock-coutermarshott-allen-manuchehrabadi-davalos-multitissueanalysisontheimpactofelectroporationonelectricalandthermalproperties-2021","author_short":["Beitel-White, N.","Lorenzo, M. F.","Zhao, Y.","Brock, R. M.","Coutermarsh-Ott, S.","Allen, I. C.","Manuchehrabadi, N.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Beitel-White"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Lorenzo"],"firstnames":["M.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Brock"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Coutermarsh-Ott"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Allen"],"firstnames":["I.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Manuchehrabadi"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Multi-Tissue Analysis on the Impact of Electroporation on Electrical and Thermal Properties","journal":"IEEE Trans Biomed Eng","volume":"68","number":"3","pages":"771-782","note":"1558-2531 Beitel-White, Natalie Lorenzo, Melvin F Zhao, Yajun Brock, Rebecca M Coutermarsh-Ott, Sheryl Allen, Irving C Manuchehrabadi, Navid Davalos, Rafael V P01 CA207206/CA/NCI NIH HHS/United States R01 CA240476/CA/NCI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States 2020/08/04 IEEE Trans Biomed Eng. 2021 Mar;68(3):771-782. doi: 10.1109/TBME.2020.3013572. Epub 2021 Feb 18.","abstract":"OBJECTIVE: Tissue electroporation is achieved by applying a series of electric pulses to destabilize cell membranes within the target tissue. The treatment volume is dictated by the electric field distribution, which depends on the pulse parameters and tissue type and can be readily predicted using numerical methods. These models require the relevant tissue properties to be known beforehand. This study aims to quantify electrical and thermal properties for three different tissue types relevant to current clinical electroporation. METHODS: Pancreatic, brain, and liver tissue were harvested from pigs, then treated with IRE pulses in a parallel-plate configuration. Resulting current and temperature readings were used to calculate the conductivity and its temperature dependence for each tissue type. Finally, a computational model was constructed to examine the impact of differences between tissue types. RESULTS: Baseline conductivity values (mean 0.11, 0.14, and 0.12 S/m) and temperature coefficients of conductivity (mean 2.0, 2.3, and 1.2 % per degree Celsius) were calculated for pancreas, brain, and liver, respectively. The accompanying computational models suggest field distribution and thermal damage volumes are dependent on tissue type. CONCLUSION: The three tissue types show similar electrical and thermal responses to IRE, though brain tissue exhibits the greatest differences. The results also show that tissue type plays a role in the expected ablation and thermal damage volumes. SIGNIFICANCE: The conductivity and its changes due to heating are expected to have a marked impact on the ablation volume. Incorporating these tissue properties aids in the prediction and optimization of electroporation-based therapies.","keywords":"Animals Electric Conductivity *Electricity *Electroporation Liver Swine Temperature","issn":"0018-9294 (Print) 0018-9294","doi":"10.1109/tbme.2020.3013572","year":"2021","bibtex":"@article{RN129,\n author = {Beitel-White, N. and Lorenzo, M. F. and Zhao, Y. and Brock, R. M. and Coutermarsh-Ott, S. and Allen, I. C. and Manuchehrabadi, N. and Davalos, R. V.},\n title = {Multi-Tissue Analysis on the Impact of Electroporation on Electrical and Thermal Properties},\n journal = {IEEE Trans Biomed Eng},\n volume = {68},\n number = {3},\n pages = {771-782},\n note = {1558-2531\nBeitel-White, Natalie\nLorenzo, Melvin F\nZhao, Yajun\nBrock, Rebecca M\nCoutermarsh-Ott, Sheryl\nAllen, Irving C\nManuchehrabadi, Navid\nDavalos, Rafael V\nP01 CA207206/CA/NCI NIH HHS/United States\nR01 CA240476/CA/NCI NIH HHS/United States\nJournal Article\nResearch Support, N.I.H., Extramural\nResearch Support, Non-U.S. Gov't\nUnited States\n2020/08/04\nIEEE Trans Biomed Eng. 2021 Mar;68(3):771-782. doi: 10.1109/TBME.2020.3013572. Epub 2021 Feb 18.},\n abstract = {OBJECTIVE: Tissue electroporation is achieved by applying a series of electric pulses to destabilize cell membranes within the target tissue. The treatment volume is dictated by the electric field distribution, which depends on the pulse parameters and tissue type and can be readily predicted using numerical methods. These models require the relevant tissue properties to be known beforehand. This study aims to quantify electrical and thermal properties for three different tissue types relevant to current clinical electroporation. METHODS: Pancreatic, brain, and liver tissue were harvested from pigs, then treated with IRE pulses in a parallel-plate configuration. Resulting current and temperature readings were used to calculate the conductivity and its temperature dependence for each tissue type. Finally, a computational model was constructed to examine the impact of differences between tissue types. RESULTS: Baseline conductivity values (mean 0.11, 0.14, and 0.12 S/m) and temperature coefficients of conductivity (mean 2.0, 2.3, and 1.2 % per degree Celsius) were calculated for pancreas, brain, and liver, respectively. The accompanying computational models suggest field distribution and thermal damage volumes are dependent on tissue type. CONCLUSION: The three tissue types show similar electrical and thermal responses to IRE, though brain tissue exhibits the greatest differences. The results also show that tissue type plays a role in the expected ablation and thermal damage volumes. SIGNIFICANCE: The conductivity and its changes due to heating are expected to have a marked impact on the ablation volume. Incorporating these tissue properties aids in the prediction and optimization of electroporation-based therapies.},\n keywords = {Animals\nElectric Conductivity\n*Electricity\n*Electroporation\nLiver\nSwine\nTemperature},\n ISSN = {0018-9294 (Print)\n0018-9294},\n DOI = {10.1109/tbme.2020.3013572},\n year = {2021},\n type = {Journal Article}\n}\n\n","author_short":["Beitel-White, N.","Lorenzo, M. F.","Zhao, Y.","Brock, R. M.","Coutermarsh-Ott, S.","Allen, I. C.","Manuchehrabadi, N.","Davalos, R. V."],"key":"RN129","id":"RN129","bibbaseid":"beitelwhite-lorenzo-zhao-brock-coutermarshott-allen-manuchehrabadi-davalos-multitissueanalysisontheimpactofelectroporationonelectricalandthermalproperties-2021","role":"author","urls":{},"keyword":["Animals Electric Conductivity *Electricity *Electroporation Liver Swine Temperature"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["animals electric conductivity *electricity *electroporation liver swine temperature"],"search_terms":["multi","tissue","analysis","impact","electroporation","electrical","thermal","properties","beitel-white","lorenzo","zhao","brock","coutermarsh-ott","allen","manuchehrabadi","davalos"],"title":"Multi-Tissue Analysis on the Impact of Electroporation on Electrical and Thermal Properties","year":2021}