Post-treatment analysis of irreversible electroporation waveforms delivered to human pancreatic cancer patients. Beitel-White, N., Martin, R. C. G., & Davalos, R. V. Annu Int Conf IEEE Eng Med Biol Soc, 2019:5518-5521, 2019. 2694-0604 Beitel-White, Natalie Martin, R C G Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't United States 2020/01/18 Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:5518-5521. doi: 10.1109/EMBC.2019.8857259.doi abstract bibtex Irreversible electroporation (IRE) is a focal ablation therapy that uses high voltage, short electrical pulses to destroy tumor tissue. The success of treatment directly depends on exposure of the entire tumor to a lethal electric field magnitude. However, this exposure is difficult to predict ahead of time and it is challenging for clinicians to determine optimal treatment parameters. One method clinicians rely upon for the cessation of pulse delivery is to monitor the resistance value of the tissue, as the cells within the tissue will undergo changes during electroporation. This work presents a computational model which incorporates human pancreatic tumor conductivity, and compares predicted and measured output currents from IRE treatments of human patients. The measured currents vary widely from patient to patient, suggesting there may areas of high local conductivity in the treatment area.
@article{RN138,
author = {Beitel-White, N. and Martin, R. C. G. and Davalos, R. V.},
title = {Post-treatment analysis of irreversible electroporation waveforms delivered to human pancreatic cancer patients},
journal = {Annu Int Conf IEEE Eng Med Biol Soc},
volume = {2019},
pages = {5518-5521},
note = {2694-0604
Beitel-White, Natalie
Martin, R C G
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
United States
2020/01/18
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:5518-5521. doi: 10.1109/EMBC.2019.8857259.},
abstract = {Irreversible electroporation (IRE) is a focal ablation therapy that uses high voltage, short electrical pulses to destroy tumor tissue. The success of treatment directly depends on exposure of the entire tumor to a lethal electric field magnitude. However, this exposure is difficult to predict ahead of time and it is challenging for clinicians to determine optimal treatment parameters. One method clinicians rely upon for the cessation of pulse delivery is to monitor the resistance value of the tissue, as the cells within the tissue will undergo changes during electroporation. This work presents a computational model which incorporates human pancreatic tumor conductivity, and compares predicted and measured output currents from IRE treatments of human patients. The measured currents vary widely from patient to patient, suggesting there may areas of high local conductivity in the treatment area.},
keywords = {Computer Simulation
Electric Conductivity
*Electroporation
Humans
*Pancreatic Neoplasms/therapy},
ISSN = {2375-7477},
DOI = {10.1109/embc.2019.8857259},
year = {2019},
type = {Journal Article}
}
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