Quaternary structures of human cytoplasmic and nuclear PCNA are the same. Belyakova, N., Pantina, R., Kovalev, R., Filatov, M., & Naryzhny, S. Biomeditsinskaya Khimiya, 63(4):356-360, Russian Academy of Medical Sciences, 2017. cited By 0![Quaternary structures of human cytoplasmic and nuclear PCNA are the same [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Properties and mechanisms of PCNA (proliferating cell nuclear antigen) functions have been investigated for a long time and are studied in great detail. As follows from its name, most known PCNA functions (DNA replication, DNA repair, DNA recombination and others) are connected with cell proliferation and localization of this protein in nuclei. In addition, there is good reason to believe that PCNA also performs some functions in the cytoplasm. However, the possible role and mechanisms of PCNA action in the cytoplasm require careful study and clarification. Interestingly, such cells as neutrophils differ in that they are non-dividing on one hand and on the other hand contain a rather large amount of PCNA, which is localized only in the cytoplasm, that is, they are an ideal model for the study of cytoplasmic PCNA. Using cross-linkages with formaldehyde, we showed that this cytoplasmic PCNA is cross-linked in a similar way, that is, organized in the same way as the nuclear PCNA that is present in the proliferating cells. Previously, we showed that PCNA in such cells is organized into a dynamic complex of double trimer on the basis of the back-to-back principle (Naryzhny S.N. et al. (2005) J. Biol. Chem., 280, 13888). Apparently, such organization of this hub-protein allows it to better coordinate the processes taking place in the cytoplasm as well.
@ARTICLE{Belyakova2017356,
author={Belyakova, N.V. and Pantina, R.A. and Kovalev, R.A. and Filatov, M.V. and Naryzhny, S.N.},
title={Quaternary structures of human cytoplasmic and nuclear PCNA are the same},
journal={Biomeditsinskaya Khimiya},
year={2017},
volume={63},
number={4},
pages={356-360},
doi={10.18097/PBMC20176304356},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028754223&doi=10.18097%2fPBMC20176304356&partnerID=40&md5=ce5cadb78677efafb3f40f9a9cf8706b},
affiliation={Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Leningrad Region (PNPI), Gatchina, 188300, Russian Federation},
abstract={Properties and mechanisms of PCNA (proliferating cell nuclear antigen) functions have been investigated for a long time and are studied in great detail. As follows from its name, most known PCNA functions (DNA replication, DNA repair, DNA recombination and others) are connected with cell proliferation and localization of this protein in nuclei. In addition, there is good reason to believe that PCNA also performs some functions in the cytoplasm. However, the possible role and mechanisms of PCNA action in the cytoplasm require careful study and clarification. Interestingly, such cells as neutrophils differ in that they are non-dividing on one hand and on the other hand contain a rather large amount of PCNA, which is localized only in the cytoplasm, that is, they are an ideal model for the study of cytoplasmic PCNA. Using cross-linkages with formaldehyde, we showed that this cytoplasmic PCNA is cross-linked in a similar way, that is, organized in the same way as the nuclear PCNA that is present in the proliferating cells. Previously, we showed that PCNA in such cells is organized into a dynamic complex of double trimer on the basis of the back-to-back principle (Naryzhny S.N. et al. (2005) J. Biol. Chem., 280, 13888). Apparently, such organization of this hub-protein allows it to better coordinate the processes taking place in the cytoplasm as well.},
author_keywords={Cytoplasm; Double trimer; Monomer; Neutrophil; PCNA; Structure},
publisher={Russian Academy of Medical Sciences},
issn={23106905},
pubmed_id={28862608},
language={Russian},
abbrev_source_title={Biomeditsinskaya Khim.},
document_type={Article},
source={Scopus},
}
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