LY 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors. Belzung, C., Cabib, S., Fabiani, L., Tolentino, P., & Puglisi-Allegra, S. Psychopharmacology, 103(4):449--454, 1991. abstract bibtex In naive mice the selective D2 agonist LY171555 dose-dependently (0.5-5 mg/kg) induces defensive responses toward non-aggressive conspecifics. In order to investigate possible anxiogenic properties of the D2 agonist, its behavioural effects were compared with those produced by the benzodiazepine receptor inverse agonist methyl-beta-carboline-3-carboxylate(beta-CCM) in the elevated plus maze and in social interactions with non-aggressive opponents. When tested in the elevated plus maze, mice injected with LY 171555 (0.005-1 mg/kg) showed no decrease either of the number of entries or of the time spent in the open arms. At 5 mg/kg an actual increase of these two measures was observed. By contrast, beta-CCM (1-3 mg/kg) dose-dependently decreased both the number of entries and the time spent in the open arms without altering locomotion. The effects of beta-CCM were antagonized by the benzodiazepine receptor antagonist RO 15-1788 (3 mg/kg) showing a selective involvement of benzodiazepine receptors in their modulation. On the other hand, beta-CCM, (1-3 mg/kg) did not produce significant effects on defensive behaviour of mice interacting with non-aggressive opponents and the defensive responses of mice treated with 1 mg/kg LY 171555 were not prevented by 5 mg/kg chlordiazepoxide. These results show that DA D2-mediated hyperdefensiveness and anxiety modulated by benzodiazepine receptors are unrelated phenomena and suggest that this behavioural response may represent a model of those forms of fear-related reaction that do not respond to benzodiazepine treatment.
@article{ belzung_ly_1991,
title = {{LY} 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors},
volume = {103},
issn = {0033-3158},
abstract = {In naive mice the selective D2 agonist {LY}171555 dose-dependently (0.5-5 mg/kg) induces defensive responses toward non-aggressive conspecifics. In order to investigate possible anxiogenic properties of the D2 agonist, its behavioural effects were compared with those produced by the benzodiazepine receptor inverse agonist methyl-beta-carboline-3-carboxylate(beta-{CCM}) in the elevated plus maze and in social interactions with non-aggressive opponents. When tested in the elevated plus maze, mice injected with {LY} 171555 (0.005-1 mg/kg) showed no decrease either of the number of entries or of the time spent in the open arms. At 5 mg/kg an actual increase of these two measures was observed. By contrast, beta-{CCM} (1-3 mg/kg) dose-dependently decreased both the number of entries and the time spent in the open arms without altering locomotion. The effects of beta-{CCM} were antagonized by the benzodiazepine receptor antagonist {RO} 15-1788 (3 mg/kg) showing a selective involvement of benzodiazepine receptors in their modulation. On the other hand, beta-{CCM}, (1-3 mg/kg) did not produce significant effects on defensive behaviour of mice interacting with non-aggressive opponents and the defensive responses of mice treated with 1 mg/kg {LY} 171555 were not prevented by 5 mg/kg chlordiazepoxide. These results show that {DA} D2-mediated hyperdefensiveness and anxiety modulated by benzodiazepine receptors are unrelated phenomena and suggest that this behavioural response may represent a model of those forms of fear-related reaction that do not respond to benzodiazepine treatment.},
language = {eng},
number = {4},
journal = {Psychopharmacology},
author = {Belzung, C. and Cabib, S. and Fabiani, L. and Tolentino, P. and Puglisi-Allegra, S.},
year = {1991},
pmid = {1676525},
keywords = {Aggression, Animals, Behavior, Animal, Carbolines, Chlordiazepoxide, Convulsants, Dopamine Agents, Dose-Response Relationship, Drug, Ergolines, Flumazenil, Mice, Mice, Inbred C57BL, Quinpirole, Receptors, {GABA}-A, Social Behavior},
pages = {449--454}
}
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{"_id":"Q3FSci3ELRuGPAkeo","authorIDs":[],"author_short":["Belzung, C.","Cabib, S.","Fabiani, L.","Tolentino, P.","Puglisi-Allegra, S."],"bibbaseid":"belzung-cabib-fabiani-tolentino-puglisiallegra-ly171555inducedhyperdefensivenessinthemousedoesnotimplicatebenzodiazepinereceptors-1991","bibdata":{"abstract":"In naive mice the selective D2 agonist LY171555 dose-dependently (0.5-5 mg/kg) induces defensive responses toward non-aggressive conspecifics. In order to investigate possible anxiogenic properties of the D2 agonist, its behavioural effects were compared with those produced by the benzodiazepine receptor inverse agonist methyl-beta-carboline-3-carboxylate(beta-CCM) in the elevated plus maze and in social interactions with non-aggressive opponents. When tested in the elevated plus maze, mice injected with LY 171555 (0.005-1 mg/kg) showed no decrease either of the number of entries or of the time spent in the open arms. At 5 mg/kg an actual increase of these two measures was observed. By contrast, beta-CCM (1-3 mg/kg) dose-dependently decreased both the number of entries and the time spent in the open arms without altering locomotion. The effects of beta-CCM were antagonized by the benzodiazepine receptor antagonist RO 15-1788 (3 mg/kg) showing a selective involvement of benzodiazepine receptors in their modulation. On the other hand, beta-CCM, (1-3 mg/kg) did not produce significant effects on defensive behaviour of mice interacting with non-aggressive opponents and the defensive responses of mice treated with 1 mg/kg LY 171555 were not prevented by 5 mg/kg chlordiazepoxide. These results show that DA D2-mediated hyperdefensiveness and anxiety modulated by benzodiazepine receptors are unrelated phenomena and suggest that this behavioural response may represent a model of those forms of fear-related reaction that do not respond to benzodiazepine treatment.","author":["Belzung, C.","Cabib, S.","Fabiani, L.","Tolentino, P.","Puglisi-Allegra, S."],"author_short":["Belzung, C.","Cabib, S.","Fabiani, L.","Tolentino, P.","Puglisi-Allegra, S."],"bibtex":"@article{ belzung_ly_1991,\n title = {{LY} 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors},\n volume = {103},\n issn = {0033-3158},\n abstract = {In naive mice the selective D2 agonist {LY}171555 dose-dependently (0.5-5 mg/kg) induces defensive responses toward non-aggressive conspecifics. In order to investigate possible anxiogenic properties of the D2 agonist, its behavioural effects were compared with those produced by the benzodiazepine receptor inverse agonist methyl-beta-carboline-3-carboxylate(beta-{CCM}) in the elevated plus maze and in social interactions with non-aggressive opponents. When tested in the elevated plus maze, mice injected with {LY} 171555 (0.005-1 mg/kg) showed no decrease either of the number of entries or of the time spent in the open arms. At 5 mg/kg an actual increase of these two measures was observed. By contrast, beta-{CCM} (1-3 mg/kg) dose-dependently decreased both the number of entries and the time spent in the open arms without altering locomotion. The effects of beta-{CCM} were antagonized by the benzodiazepine receptor antagonist {RO} 15-1788 (3 mg/kg) showing a selective involvement of benzodiazepine receptors in their modulation. On the other hand, beta-{CCM}, (1-3 mg/kg) did not produce significant effects on defensive behaviour of mice interacting with non-aggressive opponents and the defensive responses of mice treated with 1 mg/kg {LY} 171555 were not prevented by 5 mg/kg chlordiazepoxide. These results show that {DA} D2-mediated hyperdefensiveness and anxiety modulated by benzodiazepine receptors are unrelated phenomena and suggest that this behavioural response may represent a model of those forms of fear-related reaction that do not respond to benzodiazepine treatment.},\n language = {eng},\n number = {4},\n journal = {Psychopharmacology},\n author = {Belzung, C. and Cabib, S. and Fabiani, L. and Tolentino, P. and Puglisi-Allegra, S.},\n year = {1991},\n pmid = {1676525},\n keywords = {Aggression, Animals, Behavior, Animal, Carbolines, Chlordiazepoxide, Convulsants, Dopamine Agents, Dose-Response Relationship, Drug, Ergolines, Flumazenil, Mice, Mice, Inbred C57BL, Quinpirole, Receptors, {GABA}-A, Social Behavior},\n pages = {449--454}\n}","bibtype":"article","id":"belzung_ly_1991","issn":"0033-3158","journal":"Psychopharmacology","key":"belzung_ly_1991","keywords":"Aggression, Animals, Behavior, Animal, Carbolines, Chlordiazepoxide, Convulsants, Dopamine Agents, Dose-Response Relationship, Drug, Ergolines, Flumazenil, Mice, Mice, Inbred C57BL, Quinpirole, Receptors, GABA-A, Social Behavior","language":"eng","number":"4","pages":"449--454","pmid":"1676525","title":"LY 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors","type":"article","volume":"103","year":"1991","bibbaseid":"belzung-cabib-fabiani-tolentino-puglisiallegra-ly171555inducedhyperdefensivenessinthemousedoesnotimplicatebenzodiazepinereceptors-1991","role":"author","urls":{},"keyword":["Aggression","Animals","Behavior","Animal","Carbolines","Chlordiazepoxide","Convulsants","Dopamine Agents","Dose-Response Relationship","Drug","Ergolines","Flumazenil","Mice","Mice","Inbred C57BL","Quinpirole","Receptors","GABA-A","Social Behavior"],"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/brizard","creationDate":"2015-02-11T09:04:27.146Z","downloads":0,"keywords":["aggression","animals","behavior","animal","carbolines","chlordiazepoxide","convulsants","dopamine agents","dose-response relationship","drug","ergolines","flumazenil","mice","mice","inbred c57bl","quinpirole","receptors","gaba-a","social behavior"],"search_terms":["171555","induced","hyperdefensiveness","mouse","implicate","benzodiazepine","receptors","belzung","cabib","fabiani","tolentino","puglisi-allegra"],"title":"LY 171555-induced hyperdefensiveness in the mouse does not implicate benzodiazepine receptors","year":1991,"dataSources":["H9yznXMN7R8ae2jTA"]}