Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: The complex interplay between additive ions revealed. Ben-Arfa, B., Palamá, I., Miranda Salvado, I., Ferreira, J., & Pullar, R. Journal of Biomedical Materials Research - Part A, 107(12):2680-2693, John Wiley and Sons Inc., 2019. cited By 1![Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: The complex interplay between additive ions revealed [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex We show the influence of two functional ions (Cu2+ and La3+), incorporated into a quaternary (Si, Ca, Na, P) sol-gel derived bioactive glass system, on its particle size, cytotoxicity, and bioactivity. By doping the parent glass with the two ions in singular or combined forms, 15 doped glasses were prepared by a rapid sol-gel technique. The influence of the combined doping on the particle size and cell viability was successfully evaluated by the aid of signal-to-noise-ratio (S/N), using Taguchi analysis. This allowed us to analyze the complex interplay of effects between these ions, and the marked differences in biocompatibility between the three cell types studied. Cu addition had a significant effect on reducing the glass particle size, while both increased density. Cell viability was significantly improved for some doping combinations, demonstrating that while combined Cu–La doping was beneficial for biocompatibility with lymphoblasts, individual high-Cu or low-La doping was better with fibroblasts, and either high-Cu or low-La doping, or certain combined Cu–La combinations, were the optimum for osteoblasts. However, the bioactivity of doped samples was generally similar to that of the parent glass, although both La, and particularly Cu, did appear to aid dissolution of ions when immersed in SBF, act as glass modifiers, and encourage HAp crystallization. The results reveal that potential synergistic benefits can be obtained by combining the effects on the mean particle size, density, cytotoxicity, and bioactivity of the glasses. The greatly improved biocompatibility of some of the doped glasses makes them promising candidates for biomedical applications. © 2019 Wiley Periodicals, Inc.
@ARTICLE{Ben-Arfa20192680,
author={Ben-Arfa, B.A.E. and Palamá, I.E. and Miranda Salvado, I.M. and Ferreira, J.M.F. and Pullar, R.C.},
title={Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: The complex interplay between additive ions revealed},
journal={Journal of Biomedical Materials Research - Part A},
year={2019},
volume={107},
number={12},
pages={2680-2693},
doi={10.1002/jbm.a.36772},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071284911&doi=10.1002%2fjbm.a.36772&partnerID=40&md5=ed8d5e2ea06d659b70459576c3a154e9},
abstract={We show the influence of two functional ions (Cu2+ and La3+), incorporated into a quaternary (Si, Ca, Na, P) sol-gel derived bioactive glass system, on its particle size, cytotoxicity, and bioactivity. By doping the parent glass with the two ions in singular or combined forms, 15 doped glasses were prepared by a rapid sol-gel technique. The influence of the combined doping on the particle size and cell viability was successfully evaluated by the aid of signal-to-noise-ratio (S/N), using Taguchi analysis. This allowed us to analyze the complex interplay of effects between these ions, and the marked differences in biocompatibility between the three cell types studied. Cu addition had a significant effect on reducing the glass particle size, while both increased density. Cell viability was significantly improved for some doping combinations, demonstrating that while combined Cu–La doping was beneficial for biocompatibility with lymphoblasts, individual high-Cu or low-La doping was better with fibroblasts, and either high-Cu or low-La doping, or certain combined Cu–La combinations, were the optimum for osteoblasts. However, the bioactivity of doped samples was generally similar to that of the parent glass, although both La, and particularly Cu, did appear to aid dissolution of ions when immersed in SBF, act as glass modifiers, and encourage HAp crystallization. The results reveal that potential synergistic benefits can be obtained by combining the effects on the mean particle size, density, cytotoxicity, and bioactivity of the glasses. The greatly improved biocompatibility of some of the doped glasses makes them promising candidates for biomedical applications. © 2019 Wiley Periodicals, Inc.},
publisher={John Wiley and Sons Inc.},
issn={15493296},
coden={JBMRC},
pubmed_id={31390153},
document_type={Article},
source={Scopus},
}
Downloads: 0
{"_id":"XSpK4B3btY3R4ErFR","bibbaseid":"benarfa-palam-mirandasalvado-ferreira-pullar-cytotoxicityandbioactivityassessmentsforcu2andla3dopedhighsilicasolgelderivedbioglassesthecomplexinterplaybetweenadditiveionsrevealed-2019","authorIDs":[],"author_short":["Ben-Arfa, B.","Palamá, I.","Miranda Salvado, I.","Ferreira, J.","Pullar, R."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Ben-Arfa"],"firstnames":["B.A.E."],"suffixes":[]},{"propositions":[],"lastnames":["Palamá"],"firstnames":["I.E."],"suffixes":[]},{"propositions":[],"lastnames":["Miranda","Salvado"],"firstnames":["I.M."],"suffixes":[]},{"propositions":[],"lastnames":["Ferreira"],"firstnames":["J.M.F."],"suffixes":[]},{"propositions":[],"lastnames":["Pullar"],"firstnames":["R.C."],"suffixes":[]}],"title":"Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: The complex interplay between additive ions revealed","journal":"Journal of Biomedical Materials Research - Part A","year":"2019","volume":"107","number":"12","pages":"2680-2693","doi":"10.1002/jbm.a.36772","note":"cited By 1","url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071284911&doi=10.1002%2fjbm.a.36772&partnerID=40&md5=ed8d5e2ea06d659b70459576c3a154e9","abstract":"We show the influence of two functional ions (Cu2+ and La3+), incorporated into a quaternary (Si, Ca, Na, P) sol-gel derived bioactive glass system, on its particle size, cytotoxicity, and bioactivity. By doping the parent glass with the two ions in singular or combined forms, 15 doped glasses were prepared by a rapid sol-gel technique. The influence of the combined doping on the particle size and cell viability was successfully evaluated by the aid of signal-to-noise-ratio (S/N), using Taguchi analysis. This allowed us to analyze the complex interplay of effects between these ions, and the marked differences in biocompatibility between the three cell types studied. Cu addition had a significant effect on reducing the glass particle size, while both increased density. Cell viability was significantly improved for some doping combinations, demonstrating that while combined Cu–La doping was beneficial for biocompatibility with lymphoblasts, individual high-Cu or low-La doping was better with fibroblasts, and either high-Cu or low-La doping, or certain combined Cu–La combinations, were the optimum for osteoblasts. However, the bioactivity of doped samples was generally similar to that of the parent glass, although both La, and particularly Cu, did appear to aid dissolution of ions when immersed in SBF, act as glass modifiers, and encourage HAp crystallization. The results reveal that potential synergistic benefits can be obtained by combining the effects on the mean particle size, density, cytotoxicity, and bioactivity of the glasses. The greatly improved biocompatibility of some of the doped glasses makes them promising candidates for biomedical applications. © 2019 Wiley Periodicals, Inc.","publisher":"John Wiley and Sons Inc.","issn":"15493296","coden":"JBMRC","pubmed_id":"31390153","document_type":"Article","source":"Scopus","bibtex":"@ARTICLE{Ben-Arfa20192680,\nauthor={Ben-Arfa, B.A.E. and Palamá, I.E. and Miranda Salvado, I.M. and Ferreira, J.M.F. and Pullar, R.C.},\ntitle={Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: The complex interplay between additive ions revealed},\njournal={Journal of Biomedical Materials Research - Part A},\nyear={2019},\nvolume={107},\nnumber={12},\npages={2680-2693},\ndoi={10.1002/jbm.a.36772},\nnote={cited By 1},\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071284911&doi=10.1002%2fjbm.a.36772&partnerID=40&md5=ed8d5e2ea06d659b70459576c3a154e9},\nabstract={We show the influence of two functional ions (Cu2+ and La3+), incorporated into a quaternary (Si, Ca, Na, P) sol-gel derived bioactive glass system, on its particle size, cytotoxicity, and bioactivity. By doping the parent glass with the two ions in singular or combined forms, 15 doped glasses were prepared by a rapid sol-gel technique. The influence of the combined doping on the particle size and cell viability was successfully evaluated by the aid of signal-to-noise-ratio (S/N), using Taguchi analysis. This allowed us to analyze the complex interplay of effects between these ions, and the marked differences in biocompatibility between the three cell types studied. Cu addition had a significant effect on reducing the glass particle size, while both increased density. Cell viability was significantly improved for some doping combinations, demonstrating that while combined Cu–La doping was beneficial for biocompatibility with lymphoblasts, individual high-Cu or low-La doping was better with fibroblasts, and either high-Cu or low-La doping, or certain combined Cu–La combinations, were the optimum for osteoblasts. However, the bioactivity of doped samples was generally similar to that of the parent glass, although both La, and particularly Cu, did appear to aid dissolution of ions when immersed in SBF, act as glass modifiers, and encourage HAp crystallization. The results reveal that potential synergistic benefits can be obtained by combining the effects on the mean particle size, density, cytotoxicity, and bioactivity of the glasses. The greatly improved biocompatibility of some of the doped glasses makes them promising candidates for biomedical applications. © 2019 Wiley Periodicals, Inc.},\npublisher={John Wiley and Sons Inc.},\nissn={15493296},\ncoden={JBMRC},\npubmed_id={31390153},\ndocument_type={Article},\nsource={Scopus},\n}\n\n","author_short":["Ben-Arfa, B.","Palamá, I.","Miranda Salvado, I.","Ferreira, J.","Pullar, R."],"key":"Ben-Arfa20192680","id":"Ben-Arfa20192680","bibbaseid":"benarfa-palam-mirandasalvado-ferreira-pullar-cytotoxicityandbioactivityassessmentsforcu2andla3dopedhighsilicasolgelderivedbioglassesthecomplexinterplaybetweenadditiveionsrevealed-2019","role":"author","urls":{"Paper":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071284911&doi=10.1002%2fjbm.a.36772&partnerID=40&md5=ed8d5e2ea06d659b70459576c3a154e9"},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"http://nanotec.cnr.it/data/nanotec/scopus-2019.bib","creationDate":"2020-04-27T18:01:49.293Z","downloads":0,"keywords":[],"search_terms":["cytotoxicity","bioactivity","assessments","cu2","la3","doped","high","silica","sol","gel","derived","bioglasses","complex","interplay","between","additive","ions","revealed","ben-arfa","palamá","miranda salvado","ferreira","pullar"],"title":"Cytotoxicity and bioactivity assessments for Cu2+ and La3+ doped high-silica sol-gel derived bioglasses: The complex interplay between additive ions revealed","year":2019,"dataSources":["HKgFFA62AaaN8o73w","TgRzGSnFk8ZF7cwa2","8SjgEWYLNZNyufxJM"]}