@article{Benede2024,
abstract = {SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropositive or seronegative for SARS-CoV-2. SARS-CoV-2-specific CD4+ T cell responses were detectable in 83{\%} of seropositive and 60{\%} of seronegative children. Although the magnitude of the CD4+ T cell response did not differ significantly between the two groups, their functional profiles were distinct, with SARS-CoV-2 seropositive children exhibiting a higher proportion of polyfunctional T cells compared to their seronegative counterparts. The frequency of SARS-CoV-2-specific CD4+ T cells in seronegative children was associated with the endemic human coronavirus (HCoV) HKU1 IgG response. Overall, the presence of SARS-CoV-2-responding T cells in seronegative children may result from cross-reactivity to endemic coronaviruses and could contribute to the relative protection from disease observed in SARS-CoV-2-infected children.},
author = {Benede, Ntombi and Tincho, Marius B and Walters, Avril and Subbiah, Vennesa and Ngomti, Amkele and Baguma, Richard and Butters, Claire and Hahnle, Lina and Mennen, Mathilda and Skelem, Sango and Adriaanse, Marguerite and Facey-Thomas, Heidi and Scott, Christiaan and Day, Jonathan and Spracklen, Timothy F and van Graan, Strauss and Balla, Sashkia R and Moyo-Gwete, Thandeka and Moore, Penny L and MacGinty, Rae and Botha, Maresa and Workman, Lesley and Johnson, Marina and Goldblatt, David and Zar, Heather J and Ntusi, Ntobeko A B and Z{\"{u}}hlke, Liesl and Webb, Kate and Riou, Catherine and Burgers, Wendy A and Keeton, Roanne S},
doi = {10.1016/J.ISCI.2023.108728},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Benede et al. - 2024 - Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavi.pdf:pdf},
issn = {2589-0042},
journal = {iScience},
keywords = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}ack,genomics{\_}fund{\_}ack,original},
month = {jan},
number = {1},
pages = {108728},
pmid = {38235336},
publisher = {Elsevier},
title = {{Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity}},
volume = {27},
year = {2024}
}

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