White-matter lesions without lacunar infarcts in CADASIL. Benisty, S., Reyes, S., Godin, O., Herve, D., Zieren, N., Jouvent, E., Zhu, Y., During, M., Dichgans, M., & Chabriat, H. J Alzheimers Dis, 29(4):903–11, 2012. doi abstract bibtex To better characterize the clinical spectrum related to white-matter hyperintensities (WMH) in small vessel disease, 66 patients with WMH but without any lacunar infarct were selected out of a cohort of 248 CADASIL individuals. Characteristics of these patients were compared to those of patients with lacunar infarcts. Relationships between the normalized volume of WMH (nWMH), presence of microhemorrhages, brain parenchymal fraction (BPF). and cognitive performances were assessed. The Trail Making Test (TMT) A and B times, Mattis Dementia Rating Scale (MDRS) total score, attention subscore, verbal fluency score and delayed memory recall were significantly correlated with nWMH but not with BPF. Presence of microhemorrhages was associated with worse TMT B time and attention MDRS subscore after adjustment for WMH. All subjects had Mini-Mental Status Examination scores \textgreater/=24 and presented with no or only mild disability. These results suggest that CADASIL patients with isolated WMH can present with executive and attention deficit but not with severe disability and that additional lesions are needed to cause significant disability and/or dementia.
@article{benisty_white-matter_2012,
title = {White-matter lesions without lacunar infarcts in {CADASIL}},
volume = {29},
issn = {1875-8908 (Electronic) 1387-2877 (Linking)},
doi = {10.3233/JAD-2012-111784},
abstract = {To better characterize the clinical spectrum related to white-matter hyperintensities (WMH) in small vessel disease, 66 patients with WMH but without any lacunar infarct were selected out of a cohort of 248 CADASIL individuals. Characteristics of these patients were compared to those of patients with lacunar infarcts. Relationships between the normalized volume of WMH (nWMH), presence of microhemorrhages, brain parenchymal fraction (BPF). and cognitive performances were assessed. The Trail Making Test (TMT) A and B times, Mattis Dementia Rating Scale (MDRS) total score, attention subscore, verbal fluency score and delayed memory recall were significantly correlated with nWMH but not with BPF. Presence of microhemorrhages was associated with worse TMT B time and attention MDRS subscore after adjustment for WMH. All subjects had Mini-Mental Status Examination scores {\textgreater}/=24 and presented with no or only mild disability. These results suggest that CADASIL patients with isolated WMH can present with executive and attention deficit but not with severe disability and that additional lesions are needed to cause significant disability and/or dementia.},
number = {4},
journal = {J Alzheimers Dis},
author = {Benisty, S. and Reyes, S. and Godin, O. and Herve, D. and Zieren, N. and Jouvent, E. and Zhu, Y. and During, M. and Dichgans, M. and Chabriat, H.},
year = {2012},
pmid = {22330818},
keywords = {Adult, Aged, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Magnetic Resonance Imaging, Young Adult, Nerve Fibers, Myelinated/*pathology, Trail Making Test, Cohort Studies, Brain/*pathology, Cognition Disorders/etiology, CADASIL/complications/*pathology, Psychiatric Status Rating Scales, Stroke, Lacunar/pathology, Brain, Cognition Disorders, CADASIL, Nerve Fibers, Myelinated, Stroke, Lacunar},
pages = {903--11},
}
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Relationships between the normalized volume of WMH (nWMH), presence of microhemorrhages, brain parenchymal fraction (BPF). and cognitive performances were assessed. The Trail Making Test (TMT) A and B times, Mattis Dementia Rating Scale (MDRS) total score, attention subscore, verbal fluency score and delayed memory recall were significantly correlated with nWMH but not with BPF. Presence of microhemorrhages was associated with worse TMT B time and attention MDRS subscore after adjustment for WMH. All subjects had Mini-Mental Status Examination scores \\textgreater/=24 and presented with no or only mild disability. 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