Determination of a Viral Load Threshold To Distinguish Symptomatic versus Asymptomatic Rotavirus Infection in a High-Disease-Burden African Population. Bennett, A., Bar-Zeev, N., Jere, K. C., Tate, J. E., Parashar, U. D., Nakagomi, O., Heyderman, R. S., French, N., Iturriza-Gomara, M., & Cunliffe, N. A. Journal of Clinical Microbiology, 53(6):1951–1954, June, 2015. doi abstract bibtex We evaluated quantitative real-time PCR to establish the diagnosis of rotavirus gastroenteritis in a high-disease-burden population in Malawi using enzyme immunoassay as the gold standard diagnostic test. In 146 children with acute gastroenteritis and 65 asymptomatic children, we defined a cutoff point in the threshold cycle value (26.7) that predicts rotavirus-attributable gastroenteritis in this population. These data will inform the evaluation of direct and indirect rotavirus vaccine effects in Africa.
@article{bennett_determination_2015,
title = {Determination of a {Viral} {Load} {Threshold} {To} {Distinguish} {Symptomatic} versus {Asymptomatic} {Rotavirus} {Infection} in a {High}-{Disease}-{Burden} {African} {Population}},
volume = {53},
issn = {1098-660X},
doi = {10.1128/JCM.00875-15},
abstract = {We evaluated quantitative real-time PCR to establish the diagnosis of rotavirus gastroenteritis in a high-disease-burden population in Malawi using enzyme immunoassay as the gold standard diagnostic test. In 146 children with acute gastroenteritis and 65 asymptomatic children, we defined a cutoff point in the threshold cycle value (26.7) that predicts rotavirus-attributable gastroenteritis in this population. These data will inform the evaluation of direct and indirect rotavirus vaccine effects in Africa.},
language = {eng},
number = {6},
journal = {Journal of Clinical Microbiology},
author = {Bennett, A. and Bar-Zeev, N. and Jere, K. C. and Tate, J. E. and Parashar, U. D. and Nakagomi, O. and Heyderman, R. S. and French, N. and Iturriza-Gomara, M. and Cunliffe, N. A.},
month = jun,
year = {2015},
pmid = {25854480},
pmcid = {PMC4432065},
pages = {1951--1954},
}
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