SCOTfluors: Small, conjugatable, orthogonal, and tunable fluorophores for in vivo imaging of cell metabolism. Benson, S., Fernandez, A., Barth, N. D, de Moliner, F., Horrocks, M. H, Herrington, C S., Abad, J. L., Delgado, A., Kelly, L., Chang, Z., Feng, Y., Nishiura, M., Hori, Y., Kikuchi, K., & Vendrell, M. Angew. Chem. Int. Ed Engl., 58(21):6911–6915, Wiley, May, 2019.
abstract   bibtex   
The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small-sized multi-colored fluorophores for real-time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.
@ARTICLE{Benson2019-kd,
  title     = "{SCOTfluors}: Small, conjugatable, orthogonal, and tunable
               fluorophores for in vivo imaging of cell metabolism",
  author    = "Benson, Sam and Fernandez, Antonio and Barth, Nicole D and de
               Moliner, Fabio and Horrocks, Mathew H and Herrington, C Simon
               and Abad, Jose Luis and Delgado, Antonio and Kelly, Lisa and
               Chang, Ziyuan and Feng, Yi and Nishiura, Miyako and Hori,
               Yuichiro and Kikuchi, Kazuya and Vendrell, Marc",
  abstract  = "The transport and trafficking of metabolites are critical for
               the correct functioning of live cells. However, in situ
               metabolic imaging studies are hampered by the lack of
               fluorescent chemical structures that allow direct monitoring of
               small metabolites under physiological conditions with high
               spatial and temporal resolution. Herein, we describe SCOTfluors
               as novel small-sized multi-colored fluorophores for real-time
               tracking of essential metabolites in live cells and in vivo and
               for the acquisition of metabolic profiles from human cancer
               cells of variable origin.",
  journal   = "Angew. Chem. Int. Ed Engl.",
  publisher = "Wiley",
  volume    =  58,
  number    =  21,
  pages     = "6911--6915",
  month     =  may,
  year      =  2019,
  keywords  = "cancer; fluorescence; imaging agents; metabolites;
               super-resolution imaging",
  copyright = "http://creativecommons.org/licenses/by/4.0/",
  language  = "en"
}

Downloads: 0