Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Bentley, A. R, Sung, Y. J, Brown, M. R, Winkler, T. W, Kraja, A. T, Ntalla, I., Schwander, K., Chasman, D. I, Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C., Sim, X., Vojinovic, D., Huffman, J. E, Musani, S. K, Li, C., Feitosa, M. F, Richard, M. A, Noordam, R., Baker, J., Chen, G., Aschard, H., Bartz, T. M, Ding, J., Dorajoo, R., Manning, A. K, Rankinen, T., Smith, A. V, Tajuddin, S. M, Zhao, W., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Evangelou, E., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E, Hartwig, F. P, He, M., Horimoto, A. R V R, Hsu, F., Hung, Y., Jackson, A. U, Kasturiratne, A., Komulainen, P., Kuhnel, B., Leander, K., Lin, K., Luan, J., Lyytikäinen, L., Matoba, N., Nolte, I. M, Pietzner, M., Prins, B., Riaz, M., Robino, A., Said, M A., Schupf, N., Scott, R. A, Sofer, T., Stančáková, A., Takeuchi, F., Tayo, B. O, van der Most, P. J, Varga, T. V, Wang, T., Wang, Y., Ware, E. B, Wen, W., Xiang, Y., Yanek, L. R, Zhang, W., Zhao, J. H., Adeyemo, A., Afaq, S., Amin, N., Amini, M., Arking, D. E, Arzumanyan, Z., Aung, T., Ballantyne, C., Barr, R G., Bielak, L. F, Boerwinkle, E., Bottinger, E. P, Broeckel, U., Brown, M., Cade, B. E, Campbell, A., Canouil, M., Charumathi, S., Chen, Y. I., Christensen, K., Concas, M. P., Connell, J. M, de Las Fuentes, L., de Silva, H J., de Vries, P. S, Doumatey, A., Duan, Q., Eaton, C. B, Eppinga, R. N, Faul, J. D, Floyd, J. S, Forouhi, N. G, Forrester, T., Friedlander, Y., Gandin, I., Gao, H., Ghanbari, M., Gharib, S. A, Gigante, B., Giulianini, F., Grabe, H. J, Gu, C C., Harris, T. B, Heikkinen, S., Heng, C., Hirata, M., Hixson, J. E, Ikram, M A., Jia, Y., Joehanes, R., Johnson, C., Jonas, J. B., Justice, A. E, Katsuya, T., Khor, C. C., Kilpeläinen, T. O, Koh, W., Kolcic, I., Kooperberg, C., Krieger, J. E, Kritchevsky, S. B, Kubo, M., Kuusisto, J., Lakka, T. A, Langefeld, C. D, Langenberg, C., Launer, L. J, Lehne, B., Lewis, C. E, Li, Y., Liang, J., Lin, S., Liu, C., Liu, J., Liu, K., Loh, M., Lohman, K. K, Louie, T., Luzzi, A., Mägi, R., Mahajan, A., Manichaikul, A. W, McKenzie, C. A, Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mohlke, K. L, Momozawa, Y., Morris, A. P, Murray, A. D, Nalls, M. A, Nauck, M., Nelson, C. P, North, K. E, O’Connell, J. R, Palmer, N. D, Papanicolau, G. J, Pedersen, N. L, Peters, A., Peyser, P. A, Polasek, O., Poulter, N., Raitakari, O. T, Reiner, A. P, Renstrom, F., Rice, T. K, Rich, S. S, Robinson, J. G, Rose, L. M, Rosendaal, F. R, Rudan, I., Schmidt, C. O, Schreiner, P. J, Scott, W. R, Sever, P., Shi, Y., Sidney, S., Sims, M., Smith, J. A, Snieder, H., Starr, J. M, Strauch, K., Stringham, H. M, Tan, N. Y Q, Tang, H., Taylor, K. D, Teo, Y. Y., Tham, Y. C., Tiemeier, H., Turner, S. T, Uitterlinden, A. G, van Heemst, D., Waldenberger, M., Wang, H., Wang, L., Wang, L., Wei, W. B., Williams, C. A, Wilson, G., Wojczynski, M. K, Yao, J., Young, K., Yu, C., Yuan, J., Zhou, J., Zonderman, A. B, Becker, D. M, Boehnke, M., Bowden, D. W, Chambers, J. C, Cooper, R. S, de Faire, U., Deary, I. J, Elliott, P., Esko, T., Farrall, M., Franks, P. W, Freedman, B. I, Froguel, P., Gasparini, P., Gieger, C., Horta, B. L, Juang, J. J., Kamatani, Y., Kammerer, C. M, Kato, N., Kooner, J. S, Laakso, M., Laurie, C. C, Lee, I., Lehtimäki, T., Magnusson, P. K E, Oldehinkel, A. J, Penninx, B. W J H, Pereira, A. C, Rauramaa, R., Redline, S., Samani, N. J, Scott, J., Shu, X., van der Harst, P., Wagenknecht, L. E, Wang, J., Wang, Y. X., Wareham, N. J, Watkins, H., Weir, D. R, Wickremasinghe, A. R, Wu, T., Zeggini, E., Zheng, W., Bouchard, C., Evans, M. K, Gudnason, V., Kardia, S. L R, Liu, Y., Psaty, B. M, Ridker, P. M, van Dam, R. M, Mook-Kanamori, D. O, Fornage, M., Province, M. A, Kelly, T. N, Fox, E. R, Hayward, C., van Duijn, C. M, Tai, E S., Wong, T. Y., Loos, R. J F, Franceschini, N., Rotter, J. I, Zhu, X., Bierut, L. J, Gauderman, W J., Rice, K., Munroe, P. B, Morrison, A. C, Rao, D. C, Rotimi, C. N, & Cupples, L A. Nat Genet, 51:636–648, April, 2019.
doi  abstract   bibtex   
\textlessp\textgreaterThe concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.\textless/p\textgreater
@article{bentley_multi-ancestry_2019,
	title = {Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.},
	volume = {51},
	issn = {1546-1718},
	doi = {10.1038/s41588-019-0378-y},
	abstract = {{\textless}p{\textgreater}The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.{\textless}/p{\textgreater}},
	journal = {Nat Genet},
	author = {Bentley, Amy R and Sung, Yun J and Brown, Michael R and Winkler, Thomas W and Kraja, Aldi T and Ntalla, Ioanna and Schwander, Karen and Chasman, Daniel I and Lim, Elise and Deng, Xuan and Guo, Xiuqing and Liu, Jingmin and Lu, Yingchang and Cheng, Ching-Yu and Sim, Xueling and Vojinovic, Dina and Huffman, Jennifer E and Musani, Solomon K and Li, Changwei and Feitosa, Mary F and Richard, Melissa A and Noordam, Raymond and Baker, Jenna and Chen, Guanjie and Aschard, Hugues and Bartz, Traci M and Ding, Jingzhong and Dorajoo, Rajkumar and Manning, Alisa K and Rankinen, Tuomo and Smith, Albert V and Tajuddin, Salman M and Zhao, Wei and Graff, Mariaelisa and Alver, Maris and Boissel, Mathilde and Chai, Jin Fang and Chen, Xu and Divers, Jasmin and Evangelou, Evangelos and Gao, Chuan and Goel, Anuj and Hagemeijer, Yanick and Harris, Sarah E and Hartwig, Fernando P and He, Meian and Horimoto, Andrea R V R and Hsu, Fang-Chi and Hung, Yi-Jen and Jackson, Anne U and Kasturiratne, Anuradhani and Komulainen, Pirjo and Kuhnel, Brigitte and Leander, Karin and Lin, Keng-Hung and Luan, Jian’an and Lyytikäinen, Leo-Pekka and Matoba, Nana and Nolte, Ilja M and Pietzner, Maik and Prins, Bram and Riaz, Muhammad and Robino, Antonietta and Said, M Abdullah and Schupf, Nicole and Scott, Robert A and Sofer, Tamar and Stančáková, Alena and Takeuchi, Fumihiko and Tayo, Bamidele O and van der Most, Peter J and Varga, Tibor V and Wang, Tzung-Dau and Wang, Yajuan and Ware, Erin B and Wen, Wanqing and Xiang, Yong-Bing and Yanek, Lisa R and Zhang, Weihua and Zhao, Jing Hua and Adeyemo, Adebowale and Afaq, Saima and Amin, Najaf and Amini, Marzyeh and Arking, Dan E and Arzumanyan, Zorayr and Aung, Tin and Ballantyne, Christie and Barr, R Graham and Bielak, Lawrence F and Boerwinkle, Eric and Bottinger, Erwin P and Broeckel, Ulrich and Brown, Morris and Cade, Brian E and Campbell, Archie and Canouil, Mickaël and Charumathi, Sabanayagam and Chen, Yii-Der Ida and Christensen, Kaare and Concas, Maria Pina and Connell, John M and de Las Fuentes, Lisa and de Silva, H Janaka and de Vries, Paul S and Doumatey, Ayo and Duan, Qing and Eaton, Charles B and Eppinga, Ruben N and Faul, Jessica D and Floyd, James S and Forouhi, Nita G and Forrester, Terrence and Friedlander, Yechiel and Gandin, Ilaria and Gao, He and Ghanbari, Mohsen and Gharib, Sina A and Gigante, Bruna and Giulianini, Franco and Grabe, Hans J and Gu, C Charles and Harris, Tamara B and Heikkinen, Sami and Heng, Chew-Kiat and Hirata, Makoto and Hixson, James E and Ikram, M Arfan and Jia, Yucheng and Joehanes, Roby and Johnson, Craig and Jonas, Jost Bruno and Justice, Anne E and Katsuya, Tomohiro and Khor, Chiea Chuen and Kilpeläinen, Tuomas O and Koh, Woon-Puay and Kolcic, Ivana and Kooperberg, Charles and Krieger, Jose E and Kritchevsky, Stephen B and Kubo, Michiaki and Kuusisto, Johanna and Lakka, Timo A and Langefeld, Carl D and Langenberg, Claudia and Launer, Lenore J and Lehne, Benjamin and Lewis, Cora E and Li, Yize and Liang, Jingjing and Lin, Shiow and Liu, Ching-Ti and Liu, Jianjun and Liu, Kiang and Loh, Marie and Lohman, Kurt K and Louie, Tin and Luzzi, Anna and Mägi, Reedik and Mahajan, Anubha and Manichaikul, Ani W and McKenzie, Colin A and Meitinger, Thomas and Metspalu, Andres and Milaneschi, Yuri and Milani, Lili and Mohlke, Karen L and Momozawa, Yukihide and Morris, Andrew P and Murray, Alison D and Nalls, Mike A and Nauck, Matthias and Nelson, Christopher P and North, Kari E and O’Connell, Jeffrey R and Palmer, Nicholette D and Papanicolau, George J and Pedersen, Nancy L and Peters, Annette and Peyser, Patricia A and Polasek, Ozren and Poulter, Neil and Raitakari, Olli T and Reiner, Alex P and Renstrom, Frida and Rice, Treva K and Rich, Stephen S and Robinson, Jennifer G and Rose, Lynda M and Rosendaal, Frits R and Rudan, Igor and Schmidt, Carsten O and Schreiner, Pamela J and Scott, William R and Sever, Peter and Shi, Yuan and Sidney, Stephen and Sims, Mario and Smith, Jennifer A and Snieder, Harold and Starr, John M and Strauch, Konstantin and Stringham, Heather M and Tan, Nicholas Y Q and Tang, Hua and Taylor, Kent D and Teo, Yik Ying and Tham, Yih Chung and Tiemeier, Henning and Turner, Stephen T and Uitterlinden, André G and van Heemst, Diana and Waldenberger, Melanie and Wang, Heming and Wang, Lan and Wang, Lihua and Wei, Wen Bin and Williams, Christine A and Wilson, Gregory and Wojczynski, Mary K and Yao, Jie and Young, Kristin and Yu, Caizheng and Yuan, Jian-Min and Zhou, Jie and Zonderman, Alan B and Becker, Diane M and Boehnke, Michael and Bowden, Donald W and Chambers, John C and Cooper, Richard S and de Faire, Ulf and Deary, Ian J and Elliott, Paul and Esko, Tõnu and Farrall, Martin and Franks, Paul W and Freedman, Barry I and Froguel, Philippe and Gasparini, Paolo and Gieger, Christian and Horta, Bernardo L and Juang, Jyh-Ming Jimmy and Kamatani, Yoichiro and Kammerer, Candace M and Kato, Norihiro and Kooner, Jaspal S and Laakso, Markku and Laurie, Cathy C and Lee, I-Te and Lehtimäki, Terho and Magnusson, Patrik K E and Oldehinkel, Albertine J and Penninx, Brenda W J H and Pereira, Alexandre C and Rauramaa, Rainer and Redline, Susan and Samani, Nilesh J and Scott, James and Shu, Xiao-Ou and van der Harst, Pim and Wagenknecht, Lynne E and Wang, Jun-Sing and Wang, Ya Xing and Wareham, Nicholas J and Watkins, Hugh and Weir, David R and Wickremasinghe, Ananda R and Wu, Tangchun and Zeggini, Eleftheria and Zheng, Wei and Bouchard, Claude and Evans, Michele K and Gudnason, Vilmundur and Kardia, Sharon L R and Liu, Yongmei and Psaty, Bruce M and Ridker, Paul M and van Dam, Rob M and Mook-Kanamori, Dennis O and Fornage, Myriam and Province, Michael A and Kelly, Tanika N and Fox, Ervin R and Hayward, Caroline and van Duijn, Cornelia M and Tai, E Shyong and Wong, Tien Yin and Loos, Ruth J F and Franceschini, Nora and Rotter, Jerome I and Zhu, Xiaofeng and Bierut, Laura J and Gauderman, W James and Rice, Kenneth and Munroe, Patricia B and Morrison, Alanna C and Rao, Dabeeru C and Rotimi, Charles N and Cupples, L Adrienne},
	month = apr,
	year = {2019},
	pages = {636--648}
}

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