A binuclear silver complex with l-buthionine sulfoximine: synthesis, spectroscopic characterization, DFT studies and antibacterial assays

A binuclear silver complex with l-buthionine sulfoximine: synthesis, spectroscopic characterization, DFT studies and antibacterial assays. Bergamini, F., R., G., Ferreira, M., A., de Paiva, R., E., F., Gomes, A., F., Gozzo, F., C., Formiga, A., L., B., Corbi, F., C., A., Mazali, I., O., Alves, D., A., Lancellotti, M., & Corbi, P., P. RSC Advances, 2(27):10372, 2012.

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A binuclear silver(I) complex with the amino acid L-buthionine sulfoximine (BSO) of compn. Ag2C8H16N2O3S was synthesized and characterized by chem. and spectroscopic measurements, and DFT (d. functional theory) studies. Solid-state 13C NMR (SSNMR) and IR vibrational spectroscopy (IR) analyses indicate the coordination of the nitrogen and carboxylate groups of the amino acid moiety to one of the silver atoms, while coordination to the second silver atom occurs through the nitrogen of the sulfoximine group. ESI-QTOF-MS measurements show the maintenance of the binuclear structure in soln. DFT studies confirm the proposed structure as a min. of the potential energy surface (PES) with calcns. of the hessians showing no imaginary frequencies. Raman spectroscopic measurements of the [Ag2(BSO)] complex led to the assignments of the Ag-N bonds. Biol. assays of BSO and [Ag2(BSO)] were performed by the well-diffusion method over Staphyloccocus aureus (Gram-pos.), Escherichia coli and Pseudomonas aeruginosa (Gram-neg.) bacterial strains. The ligand was inactive under the tested concn. (100 $μ$g mL-1). The [Ag2(BSO)] complex was active against the Gram-neg. and Gram-pos. bacteria tested, with MIC values of 3.125 $μ$g mL-1. [on SciFinder(R)]

@article{
 title = {A binuclear silver complex with l-buthionine sulfoximine: synthesis, spectroscopic characterization, DFT studies and antibacterial assays},
 type = {article},
 year = {2012},
 keywords = {silver buthionine sulfoximine complex prepn DFT an},
 pages = {10372},
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 websites = {http://xlink.rsc.org/?DOI=c2ra21433d},
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 citation_key = {Bergamini2012},
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 abstract = {A binuclear silver(I) complex with the amino acid L-buthionine sulfoximine (BSO) of compn. Ag2C8H16N2O3S was synthesized and characterized by chem. and spectroscopic measurements, and DFT (d. functional theory) studies. Solid-state 13C NMR (SSNMR) and IR vibrational spectroscopy (IR) analyses indicate the coordination of the nitrogen and carboxylate groups of the amino acid moiety to one of the silver atoms, while coordination to the second silver atom occurs through the nitrogen of the sulfoximine group. ESI-QTOF-MS measurements show the maintenance of the binuclear structure in soln. DFT studies confirm the proposed structure as a min. of the potential energy surface (PES) with calcns. of the hessians showing no imaginary frequencies. Raman spectroscopic measurements of the [Ag2(BSO)] complex led to the assignments of the Ag-N bonds. Biol. assays of BSO and [Ag2(BSO)] were performed by the well-diffusion method over Staphyloccocus aureus (Gram-pos.), Escherichia coli and Pseudomonas aeruginosa (Gram-neg.) bacterial strains. The ligand was inactive under the tested concn. (100 $μ$g mL-1). The [Ag2(BSO)] complex was active against the Gram-neg. and Gram-pos. bacteria tested, with MIC values of 3.125 $μ$g mL-1. [on SciFinder(R)]},
 bibtype = {article},
 author = {Bergamini, Fernando Rodrigues Goulart and Ferreira, Marcos Antonio and de Paiva, Raphael Enoque Ferraz and Gomes, Alexandre Ferreira and Gozzo, Fábio Cesar and Formiga, André Luiz Barboza and Corbi, Fabiana Cristina Andrade and Mazali, Italo Odone and Alves, Danilo Antonini and Lancellotti, Marcelo and Corbi, Pedro Paulo.},
 doi = {10.1039/c2ra21433d},
 journal = {RSC Advances},
 number = {27}
}

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