Occurrence, resistance patterns and management of carbapenemase-producing bacteria in war-wounded refugees from Ukraine. Berger, F., Schmartz, G., Fritz, T., Veith, N., Alhussein, F., Roth, S., Schneitler, S., Gilcher, T., Gärtner, B., Pirpilashvili, V., Pohlemann, T., Keller, A., Rehner, J., & Becker, S. L. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 132, 04, 2023.
Occurrence, resistance patterns and management of carbapenemase-producing bacteria in war-wounded refugees from Ukraine [link]Paper  doi  abstract   bibtex   
We analysed consecutive clinical cases of infections due to carbapenemase-producing Gram-negative bacteria detected in war-wounded patients from Ukraine who were treated at one University medical centre in southwest Germany between June and December 2022. Isolates of multiresistant Gram-negative bacteria were subjected to a thorough microbiological characterisation and whole-genome sequencing. We identified five war-wounded Ukrainian patients who developed infections with NDM-1-positive Klebsiella pneumoniae. Two isolates also carried OXA-48 carbapenemases. The bacteria were resistant to novel antibiotics such as ceftazidime/avibactam and cefiderocol. Employed treatment strategies included combinations of ceftazidime/avibactam + aztreonam, colistin, or tigecycline. Whole-genome sequencing suggested transmission during primary care in Ukraine. We conclude that there is an urgent need for thorough surveillance of multiresistant pathogens in patients from war zones.
@article{ber123,
	author = {Berger, Fabian and Schmartz, Georges and Fritz, Tobias and Veith, Nils and Alhussein, Farah and Roth, Sophie and Schneitler, Sophie and Gilcher, Thomas and Gärtner, Barbara and Pirpilashvili, Vakhtang and Pohlemann, Tim and Keller, Andreas and Rehner, Jacqueline and Becker, Soeren Leif},
	year = {2023},
	month = {04},
	abstract = "{We analysed consecutive clinical cases of infections due to carbapenemase-producing Gram-negative bacteria detected in war-wounded patients from Ukraine who were treated at one University medical centre in southwest Germany between June and December 2022. Isolates of multiresistant Gram-negative bacteria were subjected to a thorough microbiological characterisation and whole-genome sequencing. We identified five war-wounded Ukrainian patients who developed infections with NDM-1-positive Klebsiella pneumoniae. Two isolates also carried OXA-48 carbapenemases. The bacteria were resistant to novel antibiotics such as ceftazidime/avibactam and cefiderocol. Employed treatment strategies included combinations of ceftazidime/avibactam + aztreonam, colistin, or tigecycline. Whole-genome sequencing suggested transmission during primary care in Ukraine. We conclude that there is an urgent need for thorough surveillance of multiresistant pathogens in patients from war zones.}",
	pages = {},
	title = {Occurrence, resistance patterns and management of carbapenemase-producing bacteria in war-wounded refugees from Ukraine},
	volume = {132},
	journal = {International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases},
    	url = {https://doi.org/10.1016/j.ijid.2023.04.394},
	doi = {10.1016/j.ijid.2023.04.394}
}

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