Zinc and Copper Status and Blood Pressure. Bergomi, M., Rovesti, S., Vinceti, M., Vivoli, R., Caselgrandi, E., & Vivoli, G. Journal of Trace Elements in Medicine and Biology, 11(3):166–169, January, 1997.
Zinc and Copper Status and Blood Pressure [link]Paper  doi  abstract   bibtex   
In order to elucidate the relationships between Zn and Cu and blood pressure, the present case-control study was carried out. Zn and Cu status was evaluated in 60 subjects, pharmacologically untreated, affected by mild stable hypertension and in 60 normotensives matched for sex, age and smoking habits. Different markers of Zn and Cu status, including serum, erythrocyte and urine levels of the two trace elements and activities of some Zn- or Cu-dependent enzymes (alkaline phosphatase, lactic dehydrogenase, superoxide dismutase and lysyl oxidase) were evaluated. No significant difference between hypertensives and normotensives was observed in the mean levels of Zn and Cu as well as in Zn- or Cu-dependent enzymes, though higher levels of serum copper were associated with increased risk of hypertension. Interesting relationships between the biological parameters investigated were observed in the hypertensive subjects. Inverse correlations between blood pressures and serum Zn were observed. Furthermore, blood pressure was inversely related to lysyl oxidase activity. These findings give further support to the hypothesis that an imbalance of Zn and Cu bioavailability may be associated to hypertensive condition.
@article{bergomi_zinc_1997,
	title = {Zinc and {Copper} {Status} and {Blood} {Pressure}},
	volume = {11},
	issn = {0946-672X},
	url = {http://www.sciencedirect.com/science/article/pii/S0946672X97800478},
	doi = {10.1016/S0946-672X(97)80047-8},
	abstract = {In order to elucidate the relationships between Zn and Cu and blood pressure, the present case-control study was carried out. Zn and Cu status was evaluated in 60 subjects, pharmacologically untreated, affected by mild stable hypertension and in 60 normotensives matched for sex, age and smoking habits. Different markers of Zn and Cu status, including serum, erythrocyte and urine levels of the two trace elements and activities of some Zn- or Cu-dependent enzymes (alkaline phosphatase, lactic dehydrogenase, superoxide dismutase and lysyl oxidase) were evaluated. No significant difference between hypertensives and normotensives was observed in the mean levels of Zn and Cu as well as in Zn- or Cu-dependent enzymes, though higher levels of serum copper were associated with increased risk of hypertension. Interesting relationships between the biological parameters investigated were observed in the hypertensive subjects. Inverse correlations between blood pressures and serum Zn were observed. Furthermore, blood pressure was inversely related to lysyl oxidase activity. These findings give further support to the hypothesis that an imbalance of Zn and Cu bioavailability may be associated to hypertensive condition.},
	language = {en},
	number = {3},
	urldate = {2020-03-09},
	journal = {Journal of Trace Elements in Medicine and Biology},
	author = {Bergomi, M. and Rovesti, S. and Vinceti, M. and Vivoli, R. and Caselgrandi, E. and Vivoli, G.},
	month = jan,
	year = {1997},
	keywords = {Zinc, copper, hypertension, lysyl oxidase, superoxide dismutase},
	pages = {166--169},
}

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