Electrocardiogram monitoring: computerized detection of ventricular changes induced by drugs. Berni, A J, Luttges, M W, & Dick, D E Science (New York, N.Y.), 179(4080):1338–1340, March, 1973.
abstract   bibtex   
Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantoin. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.
@article{berni_electrocardiogram_1973,
	title = {Electrocardiogram monitoring: computerized detection of ventricular changes induced by drugs},
	volume = {179},
	issn = {0036-8075},
	shorttitle = {Electrocardiogram monitoring},
	abstract = {Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantoin. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.},
	language = {eng},
	number = {4080},
	journal = {Science (New York, N.Y.)},
	author = {Berni, A J and Luttges, M W and Dick, D E},
	month = mar,
	year = {1973},
	pmid = {4687024},
	keywords = {Animals, Computers, Electrocardiography, Heart Rate, Heart Ventricles, Lidocaine, Methods, Mice, Monitoring, Physiologic, Ouabain, Phenytoin},
	pages = {1338--1340}
}

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