Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice. Berry, R. L., Ozdemir, D. D., Aronow, B., Lindström, N. O., Dudnakova, T., Thornburn, A., Perry, P., Baldock, R., Armit, C., Joshi, A., Jeanpierre, C., Shan, J., Vainio, S., Baily, J., Brownstein, D., Davies, J., Hastie, N. D., & Hohenstein, P. Disease Models & Mechanisms, 8(8):903–917, August, 2015. ![Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Skip to Next Section Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in different stages of nephron development before and after the mesenchymal-to-epithelial transition (MET). We demonstrate that Wt1 is essential for normal development at all kidney developmental stages under study. Comparison of genome-wide expression data from the mutant mouse models with human tumour material of mutant or wild-type WT1 datasets identified the stage of origin of human WT1-mutant tumours, and emphasizes fundamental differences between the two human tumour groups due to different developmental stages of origin.
@article{berry_deducing_2015,
title = {Deducing the stage of origin of {Wilms}' tumours from a developmental series of {Wt1}-mutant mice},
volume = {8},
copyright = {© 2015. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.},
issn = {1754-8403, 1754-8411},
url = {https://dmm.biologists.org/content/8/8/903},
doi = {10.1242/dmm.018523},
abstract = {Skip to Next Section
Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in different stages of nephron development before and after the mesenchymal-to-epithelial transition (MET). We demonstrate that Wt1 is essential for normal development at all kidney developmental stages under study. Comparison of genome-wide expression data from the mutant mouse models with human tumour material of mutant or wild-type WT1 datasets identified the stage of origin of human WT1-mutant tumours, and emphasizes fundamental differences between the two human tumour groups due to different developmental stages of origin.},
language = {en},
number = {8},
urldate = {2019-08-29},
journal = {Disease Models \& Mechanisms},
author = {Berry, Rachel L. and Ozdemir, Derya D. and Aronow, Bruce and Lindström, Nils O. and Dudnakova, Tatiana and Thornburn, Anna and Perry, Paul and Baldock, Richard and Armit, Chris and Joshi, Anagha and Jeanpierre, Cécile and Shan, Jingdong and Vainio, Seppo and Baily, James and Brownstein, David and Davies, Jamie and Hastie, Nicholas D. and Hohenstein, Peter},
month = aug,
year = {2015},
pmid = {26035382},
pages = {903--917},
file = {Full Text PDF:/Users/cristina/Zotero/storage/2Y5EMGQQ/Berry et al. - 2015 - Deducing the stage of origin of Wilms' tumours fro.pdf:application/pdf;Snapshot:/Users/cristina/Zotero/storage/EVCS3VL3/903.html:text/html},
}
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