@article{RN165,
   author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Ebus, S. C. and de Louw, A. J. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Delayed convergence between brain network structure and function in rolandic epilepsy},
   journal = {Front Hum Neurosci},
   volume = {8},
   pages = {704},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
Overvliet, Geke M
van der Kruijs, Sylvie J M
Ebus, Saskia C M
de Louw, Anton J A
Hofman, Paul A M
Aldenkamp, Albert P
Backes, Walter H
eng
Switzerland
2014/09/25 06:00
Front Hum Neurosci. 2014 Sep 9;8:704. doi: 10.3389/fnhum.2014.00704. eCollection 2014.},
   abstract = {INTRODUCTION: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. METHODS: Twenty-two children with RE (age, mean +/- SD: 11.3 +/- 2.0 y) and 22 healthy controls (age 10.5 +/- 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01-0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. RESULTS: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. CONCLUSION: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of epileptiform activity, and bear relevance for language function.},
   keywords = {brain maturation
functional connectivity
graph theory
rolandic epilepsy
structural connectivity
structure-function correlation},
   ISSN = {1662-5161 (Print)
1662-5161 (Linking)},
   DOI = {10.3389/fnhum.2014.00704},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/25249968
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158874/pdf/fnhum-08-00704.pdf},
   year = {2014},
   type = {Journal Article}
}

{"_id":"cxGbbSP6qH4LYbdaz","bibbaseid":"besseling-jansen-overvliet-vanderkruijs-ebus-delouw-hofman-aldenkamp-etal-delayedconvergencebetweenbrainnetworkstructureandfunctioninrolandicepilepsy-2014","downloads":0,"creationDate":"2017-09-02T18:10:13.479Z","title":"Delayed convergence between brain network structure and function in rolandic epilepsy","author_short":["Besseling, R. M.","Jansen, J. F.","Overvliet, G. M.","van der Kruijs, S. J.","Ebus, S. C.","de Louw, A. J.","Hofman, P. A.","Aldenkamp, A. P.","Backes, W. H."],"year":2014,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Besseling"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Overvliet"],"firstnames":["G.","M."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kruijs"],"firstnames":["S.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Ebus"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Delayed convergence between brain network structure and function in rolandic epilepsy","journal":"Front Hum Neurosci","volume":"8","pages":"704","note":"Besseling, Rene M H Jansen, Jacobus F A Overvliet, Geke M van der Kruijs, Sylvie J M Ebus, Saskia C M de Louw, Anton J A Hofman, Paul A M Aldenkamp, Albert P Backes, Walter H eng Switzerland 2014/09/25 06:00 Front Hum Neurosci. 2014 Sep 9;8:704. doi: 10.3389/fnhum.2014.00704. eCollection 2014.","abstract":"INTRODUCTION: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. METHODS: Twenty-two children with RE (age, mean +/- SD: 11.3 +/- 2.0 y) and 22 healthy controls (age 10.5 +/- 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01-0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. RESULTS: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. CONCLUSION: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of epileptiform activity, and bear relevance for language function.","keywords":"brain maturation functional connectivity graph theory rolandic epilepsy structural connectivity structure-function correlation","issn":"1662-5161 (Print) 1662-5161 (Linking)","doi":"10.3389/fnhum.2014.00704","url":"http://www.ncbi.nlm.nih.gov/pubmed/25249968 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158874/pdf/fnhum-08-00704.pdf","year":"2014","bibtex":"@article{RN165,\n author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Ebus, S. C. and de Louw, A. J. and Hofman, P. A. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Delayed convergence between brain network structure and function in rolandic epilepsy},\n journal = {Front Hum Neurosci},\n volume = {8},\n pages = {704},\n note = {Besseling, Rene M H\nJansen, Jacobus F A\nOvervliet, Geke M\nvan der Kruijs, Sylvie J M\nEbus, Saskia C M\nde Louw, Anton J A\nHofman, Paul A M\nAldenkamp, Albert P\nBackes, Walter H\neng\nSwitzerland\n2014/09/25 06:00\nFront Hum Neurosci. 2014 Sep 9;8:704. doi: 10.3389/fnhum.2014.00704. eCollection 2014.},\n abstract = {INTRODUCTION: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. METHODS: Twenty-two children with RE (age, mean +/- SD: 11.3 +/- 2.0 y) and 22 healthy controls (age 10.5 +/- 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01-0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. RESULTS: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. CONCLUSION: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of epileptiform activity, and bear relevance for language function.},\n keywords = {brain maturation\nfunctional connectivity\ngraph theory\nrolandic epilepsy\nstructural connectivity\nstructure-function correlation},\n ISSN = {1662-5161 (Print)\n1662-5161 (Linking)},\n DOI = {10.3389/fnhum.2014.00704},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/25249968\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158874/pdf/fnhum-08-00704.pdf},\n year = {2014},\n type = {Journal Article}\n}\n\n","author_short":["Besseling, R. M.","Jansen, J. F.","Overvliet, G. M.","van der Kruijs, S. J.","Ebus, S. C.","de Louw, A. J.","Hofman, P. A.","Aldenkamp, A. P.","Backes, W. 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