@article{RN157,
   author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Ebus, S. C. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy},
   journal = {PLoS One},
   volume = {8},
   number = {12},
   pages = {e83568},
   note = {Besseling, Rene M H
Jansen, Jacobus F A
Overvliet, Geke M
van der Kruijs, Sylvie J M
Ebus, Saskia C M
de Louw, Anton
Hofman, Paul A M
Vles, Johannes S H
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
2014/01/01 06:00
PLoS One. 2013 Dec 23;8(12):e83568. doi: 10.1371/journal.pone.0083568. eCollection 2013.},
   abstract = {INTRODUCTION: Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. METHODS: Twenty-three children with RE and 23 matched controls (age: 8-14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm(2), 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. RESULTS: Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). CONCLUSION: In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca's area) and the supramarginal gyrus (Wernicke's area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE.},
   keywords = {Adolescent
Anisotropy
Case-Control Studies
Child
Diffusion Tensor Imaging
Epilepsy, Rolandic/*pathology/physiopathology
Female
Humans
*Language
Language Tests
Male
Sensorimotor Cortex/*pathology/physiopathology
White Matter/*pathology/physiopathology},
   ISSN = {1932-6203 (Electronic)
1932-6203 (Linking)},
   DOI = {10.1371/journal.pone.0083568},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24376719
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871667/pdf/pone.0083568.pdf},
   year = {2013},
   type = {Journal Article}
}

{"_id":"h6LzJYqtxK6jZY3DA","bibbaseid":"besseling-jansen-overvliet-vanderkruijs-ebus-delouw-hofman-vles-etal-reducedstructuralconnectivitybetweensensorimotorandlanguageareasinrolandicepilepsy-2013","downloads":0,"creationDate":"2017-09-02T18:10:13.491Z","title":"Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy","author_short":["Besseling, R. M.","Jansen, J. F.","Overvliet, G. M.","van der Kruijs, S. J.","Ebus, S. C.","de Louw, A.","Hofman, P. A.","Vles, J. S.","Aldenkamp, A. P.","Backes, W. H."],"year":2013,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Besseling"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Overvliet"],"firstnames":["G.","M."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kruijs"],"firstnames":["S.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Ebus"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Vles"],"firstnames":["J.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy","journal":"PLoS One","volume":"8","number":"12","pages":"e83568","note":"Besseling, Rene M H Jansen, Jacobus F A Overvliet, Geke M van der Kruijs, Sylvie J M Ebus, Saskia C M de Louw, Anton Hofman, Paul A M Vles, Johannes S H Aldenkamp, Albert P Backes, Walter H eng Research Support, Non-U.S. Gov't 2014/01/01 06:00 PLoS One. 2013 Dec 23;8(12):e83568. doi: 10.1371/journal.pone.0083568. eCollection 2013.","abstract":"INTRODUCTION: Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. METHODS: Twenty-three children with RE and 23 matched controls (age: 8-14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm(2), 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. RESULTS: Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). CONCLUSION: In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca's area) and the supramarginal gyrus (Wernicke's area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE.","keywords":"Adolescent Anisotropy Case-Control Studies Child Diffusion Tensor Imaging Epilepsy, Rolandic/*pathology/physiopathology Female Humans *Language Language Tests Male Sensorimotor Cortex/*pathology/physiopathology White Matter/*pathology/physiopathology","issn":"1932-6203 (Electronic) 1932-6203 (Linking)","doi":"10.1371/journal.pone.0083568","url":"http://www.ncbi.nlm.nih.gov/pubmed/24376719 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871667/pdf/pone.0083568.pdf","year":"2013","bibtex":"@article{RN157,\n author = {Besseling, R. M. and Jansen, J. F. and Overvliet, G. M. and van der Kruijs, S. J. and Ebus, S. C. and de Louw, A. and Hofman, P. A. and Vles, J. S. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Reduced structural connectivity between sensorimotor and language areas in rolandic epilepsy},\n journal = {PLoS One},\n volume = {8},\n number = {12},\n pages = {e83568},\n note = {Besseling, Rene M H\nJansen, Jacobus F A\nOvervliet, Geke M\nvan der Kruijs, Sylvie J M\nEbus, Saskia C M\nde Louw, Anton\nHofman, Paul A M\nVles, Johannes S H\nAldenkamp, Albert P\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\n2014/01/01 06:00\nPLoS One. 2013 Dec 23;8(12):e83568. doi: 10.1371/journal.pone.0083568. eCollection 2013.},\n abstract = {INTRODUCTION: Rolandic epilepsy (RE) is a childhood epilepsy with centrotemporal (rolandic) spikes, that is increasingly associated with language impairment. In this study, we tested for a white matter (connectivity) correlate, employing diffusion weighted MRI and language testing. METHODS: Twenty-three children with RE and 23 matched controls (age: 8-14 years) underwent structural (T1-weighted) and diffusion-weighted MRI (b = 1200 s/mm(2), 66 gradient directions) at 3T, as well as neuropsychological language testing. Combining tractography and a cortical segmentation derived from the T1-scan, the rolandic tract were reconstructed (pre- and postcentral gyri), and tract fractional anisotropy (FA) values were compared between patients and controls. Aberrant tracts were tested for correlations with language performance. RESULTS: Several reductions of tract FA were found in patients compared to controls, mostly in the left hemisphere; the most significant effects involved the left inferior frontal (p = 0.005) and supramarginal (p = 0.004) gyrus. In the patient group, lower tract FA values were correlated with lower language performance, among others for the connection between the left postcentral and inferior frontal gyrus (p = 0.043, R = 0.43). CONCLUSION: In RE, structural connectivity is reduced for several connections involving the rolandic regions, from which the epileptiform activity originates. Most of these aberrant tracts involve the left (typically language mediating) hemisphere, notably the pars opercularis of the inferior frontal gyrus (Broca's area) and the supramarginal gyrus (Wernicke's area). For the former, reduced language performance for lower tract FA was found in the patients. These findings provide a first microstructural white matter correlate for language impairment in RE.},\n keywords = {Adolescent\nAnisotropy\nCase-Control Studies\nChild\nDiffusion Tensor Imaging\nEpilepsy, Rolandic/*pathology/physiopathology\nFemale\nHumans\n*Language\nLanguage Tests\nMale\nSensorimotor Cortex/*pathology/physiopathology\nWhite Matter/*pathology/physiopathology},\n ISSN = {1932-6203 (Electronic)\n1932-6203 (Linking)},\n DOI = {10.1371/journal.pone.0083568},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/24376719\nhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871667/pdf/pone.0083568.pdf},\n year = {2013},\n type = {Journal Article}\n}\n\n","author_short":["Besseling, R. M.","Jansen, J. F.","Overvliet, G. M.","van der Kruijs, S. J.","Ebus, S. C.","de Louw, A.","Hofman, P. A.","Vles, J. S.","Aldenkamp, A. P.","Backes, W. H."],"key":"RN157","id":"RN157","bibbaseid":"besseling-jansen-overvliet-vanderkruijs-ebus-delouw-hofman-vles-etal-reducedstructuralconnectivitybetweensensorimotorandlanguageareasinrolandicepilepsy-2013","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/24376719 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871667/pdf/pone.0083568.pdf"},"keyword":["Adolescent Anisotropy Case-Control Studies Child Diffusion Tensor Imaging Epilepsy","Rolandic/*pathology/physiopathology Female Humans *Language Language Tests Male Sensorimotor Cortex/*pathology/physiopathology White Matter/*pathology/physiopathology"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["reduced","structural","connectivity","between","sensorimotor","language","areas","rolandic","epilepsy","besseling","jansen","overvliet","van der kruijs","ebus","de louw","hofman","vles","aldenkamp","backes"],"keywords":["adolescent anisotropy case-control studies child diffusion tensor imaging epilepsy","rolandic/*pathology/physiopathology female humans *language language tests male sensorimotor cortex/*pathology/physiopathology white matter/*pathology/physiopathology"],"authorIDs":["59aae01e5ead235c6f00001d","5df1707557cfb4de0100001d","5e024e386ffa15df0100007a","5e47cbe8af70c7de0100001a","5e4ea88f64b624de01000110","5e685fc7149172de01000144","9uYiZAT4SGYEdwuhG","CHX5tw5dNmS7tFMt9","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","H6wbK4u5jYRFL8LDs","Jeci2sNzJiMSDeJvc","QqoDaykDZWJd9YuAu","RLbGKAvkbQAw2q2pz","TCejZCDssndxpTcJg","TEAWLnKpXtQE8hs6C","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","gxe8DkJ5qKbznZgZq","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","ryLRyF5HAWnpncbbr","sFGhcvCCManvCwLHz","zTR82AHQxLXLWt4wi"],"dataSources":["TCkfRWJAZvbLAZi29"]}