@article{RN159,
   author = {Besseling, R. M. and Overvliet, G. M. and Jansen, J. F. and van der Kruijs, S. J. and Vles, J. S. and Ebus, S. C. and Hofman, P. A. and de Louw, A. J. and Aldenkamp, A. P. and Backes, W. H.},
   title = {Aberrant functional connectivity between motor and language networks in rolandic epilepsy},
   journal = {Epilepsy Res},
   volume = {107},
   number = {3},
   pages = {253-62},
   note = {Besseling, Rene M H
Overvliet, Geke M
Jansen, Jacobus F A
van der Kruijs, Sylvie J M
Vles, Johannes S H
Ebus, Saskia C M
Hofman, Paul A M
de Louw, Anton J A
Aldenkamp, Albert P
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
Netherlands
2013/11/12 06:00
Epilepsy Res. 2013 Dec;107(3):253-62. doi: 10.1016/j.eplepsyres.2013.10.008. Epub 2013 Oct 23.},
   abstract = {INTRODUCTION: Rolandic epilepsy (RE) is an idiopathic focal childhood epilepsy with a well-established neuropsychological profile of language impairment. The aim of this study is to provide a functional correlate that links rolandic (sensorimotor) pathology to language problems using functional MRI. MATERIALS AND METHODS: Twenty-three children with RE (8-14 years old) and 21 matched controls underwent extensive language assessment (Clinical Evaluation of Language Fundamentals). fMRI was performed at rest and using word generation, reading, and finger tapping paradigms. Since no activation group differences were found, regions of interest (ROIs) were defined at pooled (patients and controls combined) activation maxima and in contralateral homotopic cortex, and used to assess language lateralization as well as for a resting-state connectivity analysis. Furthermore, the association between connection strength and language performance was investigated. RESULTS: Reduced language performance was found in the children with RE. Bilateral activation was found for both language tasks with some predominance of the left hemisphere in both groups. Compared to controls, patient connectivity was decreased between the left sensorimotor area and right inferior frontal gyrus (p<0.01). For this connection, lower connectivity was associated with lower language scores in the patient group (r=0.49, p=0.02), but not in the controls. CONCLUSION: Language laterality analysis revealed bilateral language representation in the age range under study (8-14 years). As a consequence, the connection of reduced functional connectivity we found represents an impaired interplay between motor and language networks, and aberrant functional connectivity associated with poorer language performance. These findings provide a first neuronal correlate in terms of aberrant resting-state functional connectivity for language impairment in RE.},
   keywords = {Adolescent
Cerebral Cortex/*pathology/physiology
Child
Epilepsy, Rolandic/*diagnosis/physiopathology
Female
Humans
*Language
Language Tests
Magnetic Resonance Imaging/methods
Male
Nerve Net/*pathology/*physiology
Psychomotor Performance/*physiology
Sensory Gating/physiology
Benign rolandic epilepsy of childhood with centro temporal spikes
Language impairment
Re
Resting-state functional MRI
rolandic epilepsy},
   ISSN = {1872-6844 (Electronic)
0920-1211 (Linking)},
   DOI = {10.1016/j.eplepsyres.2013.10.008},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/24210960
https://www.sciencedirect.com/science/article/abs/pii/S0920121113002623?via%3Dihub},
   year = {2013},
   type = {Journal Article}
}

{"_id":"Yp2gYCyYuJeH5gvYn","bibbaseid":"besseling-overvliet-jansen-vanderkruijs-vles-ebus-hofman-delouw-etal-aberrantfunctionalconnectivitybetweenmotorandlanguagenetworksinrolandicepilepsy-2013","downloads":0,"creationDate":"2017-09-02T18:10:13.495Z","title":"Aberrant functional connectivity between motor and language networks in rolandic epilepsy","author_short":["Besseling, R. M.","Overvliet, G. M.","Jansen, J. F.","van der Kruijs, S. J.","Vles, J. S.","Ebus, S. C.","Hofman, P. A.","de Louw, A. J.","Aldenkamp, A. P.","Backes, W. H."],"year":2013,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Besseling"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Overvliet"],"firstnames":["G.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kruijs"],"firstnames":["S.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Vles"],"firstnames":["J.","S."],"suffixes":[]},{"propositions":[],"lastnames":["Ebus"],"firstnames":["S.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Aberrant functional connectivity between motor and language networks in rolandic epilepsy","journal":"Epilepsy Res","volume":"107","number":"3","pages":"253-62","note":"Besseling, Rene M H Overvliet, Geke M Jansen, Jacobus F A van der Kruijs, Sylvie J M Vles, Johannes S H Ebus, Saskia C M Hofman, Paul A M de Louw, Anton J A Aldenkamp, Albert P Backes, Walter H eng Research Support, Non-U.S. Gov't Netherlands 2013/11/12 06:00 Epilepsy Res. 2013 Dec;107(3):253-62. doi: 10.1016/j.eplepsyres.2013.10.008. Epub 2013 Oct 23.","abstract":"INTRODUCTION: Rolandic epilepsy (RE) is an idiopathic focal childhood epilepsy with a well-established neuropsychological profile of language impairment. The aim of this study is to provide a functional correlate that links rolandic (sensorimotor) pathology to language problems using functional MRI. MATERIALS AND METHODS: Twenty-three children with RE (8-14 years old) and 21 matched controls underwent extensive language assessment (Clinical Evaluation of Language Fundamentals). fMRI was performed at rest and using word generation, reading, and finger tapping paradigms. Since no activation group differences were found, regions of interest (ROIs) were defined at pooled (patients and controls combined) activation maxima and in contralateral homotopic cortex, and used to assess language lateralization as well as for a resting-state connectivity analysis. Furthermore, the association between connection strength and language performance was investigated. RESULTS: Reduced language performance was found in the children with RE. Bilateral activation was found for both language tasks with some predominance of the left hemisphere in both groups. Compared to controls, patient connectivity was decreased between the left sensorimotor area and right inferior frontal gyrus (p<0.01). For this connection, lower connectivity was associated with lower language scores in the patient group (r=0.49, p=0.02), but not in the controls. CONCLUSION: Language laterality analysis revealed bilateral language representation in the age range under study (8-14 years). As a consequence, the connection of reduced functional connectivity we found represents an impaired interplay between motor and language networks, and aberrant functional connectivity associated with poorer language performance. These findings provide a first neuronal correlate in terms of aberrant resting-state functional connectivity for language impairment in RE.","keywords":"Adolescent Cerebral Cortex/*pathology/physiology Child Epilepsy, Rolandic/*diagnosis/physiopathology Female Humans *Language Language Tests Magnetic Resonance Imaging/methods Male Nerve Net/*pathology/*physiology Psychomotor Performance/*physiology Sensory Gating/physiology Benign rolandic epilepsy of childhood with centro temporal spikes Language impairment Re Resting-state functional MRI rolandic epilepsy","issn":"1872-6844 (Electronic) 0920-1211 (Linking)","doi":"10.1016/j.eplepsyres.2013.10.008","url":"http://www.ncbi.nlm.nih.gov/pubmed/24210960 https://www.sciencedirect.com/science/article/abs/pii/S0920121113002623?via%3Dihub","year":"2013","bibtex":"@article{RN159,\n author = {Besseling, R. M. and Overvliet, G. M. and Jansen, J. F. and van der Kruijs, S. J. and Vles, J. S. and Ebus, S. C. and Hofman, P. A. and de Louw, A. J. and Aldenkamp, A. P. and Backes, W. H.},\n title = {Aberrant functional connectivity between motor and language networks in rolandic epilepsy},\n journal = {Epilepsy Res},\n volume = {107},\n number = {3},\n pages = {253-62},\n note = {Besseling, Rene M H\nOvervliet, Geke M\nJansen, Jacobus F A\nvan der Kruijs, Sylvie J M\nVles, Johannes S H\nEbus, Saskia C M\nHofman, Paul A M\nde Louw, Anton J A\nAldenkamp, Albert P\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\nNetherlands\n2013/11/12 06:00\nEpilepsy Res. 2013 Dec;107(3):253-62. doi: 10.1016/j.eplepsyres.2013.10.008. Epub 2013 Oct 23.},\n abstract = {INTRODUCTION: Rolandic epilepsy (RE) is an idiopathic focal childhood epilepsy with a well-established neuropsychological profile of language impairment. The aim of this study is to provide a functional correlate that links rolandic (sensorimotor) pathology to language problems using functional MRI. MATERIALS AND METHODS: Twenty-three children with RE (8-14 years old) and 21 matched controls underwent extensive language assessment (Clinical Evaluation of Language Fundamentals). fMRI was performed at rest and using word generation, reading, and finger tapping paradigms. Since no activation group differences were found, regions of interest (ROIs) were defined at pooled (patients and controls combined) activation maxima and in contralateral homotopic cortex, and used to assess language lateralization as well as for a resting-state connectivity analysis. Furthermore, the association between connection strength and language performance was investigated. RESULTS: Reduced language performance was found in the children with RE. Bilateral activation was found for both language tasks with some predominance of the left hemisphere in both groups. Compared to controls, patient connectivity was decreased between the left sensorimotor area and right inferior frontal gyrus (p<0.01). For this connection, lower connectivity was associated with lower language scores in the patient group (r=0.49, p=0.02), but not in the controls. CONCLUSION: Language laterality analysis revealed bilateral language representation in the age range under study (8-14 years). As a consequence, the connection of reduced functional connectivity we found represents an impaired interplay between motor and language networks, and aberrant functional connectivity associated with poorer language performance. These findings provide a first neuronal correlate in terms of aberrant resting-state functional connectivity for language impairment in RE.},\n keywords = {Adolescent\nCerebral Cortex/*pathology/physiology\nChild\nEpilepsy, Rolandic/*diagnosis/physiopathology\nFemale\nHumans\n*Language\nLanguage Tests\nMagnetic Resonance Imaging/methods\nMale\nNerve Net/*pathology/*physiology\nPsychomotor Performance/*physiology\nSensory Gating/physiology\nBenign rolandic epilepsy of childhood with centro temporal spikes\nLanguage impairment\nRe\nResting-state functional MRI\nrolandic epilepsy},\n ISSN = {1872-6844 (Electronic)\n0920-1211 (Linking)},\n DOI = {10.1016/j.eplepsyres.2013.10.008},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/24210960\nhttps://www.sciencedirect.com/science/article/abs/pii/S0920121113002623?via%3Dihub},\n year = {2013},\n type = {Journal Article}\n}\n\n","author_short":["Besseling, R. M.","Overvliet, G. M.","Jansen, J. F.","van der Kruijs, S. J.","Vles, J. S.","Ebus, S. 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