Spectroscopic, Molecular Modeling, and NMR-spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-quadruplex DNA. Bessi, I., Bazzicalupi, C., Richter, C., a Jonker, H. R, Saxena, K., Sissi, C., Chioccioli, M., Bianco, S., Bilia, A. R., Schwalbe, H., & Gratteri, P. ACS chemical biology, 7(6):1109–19, June, 2012. doi abstract bibtex G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA, and ligands able to stabilize this structure have recently been identified as potential anticancer drugs. Among the potential G-quadruplex binders, we have studied the binding ability of berberine and sanguinarine, two members of the alkaloid family, an important class of natural products long known for medicinal purpose. Our spectroscopic (CD, NMR, and fluorescence) studies and molecular modeling approaches revealed binding modes at ligand-complex stoichiometries ¿1:1 and ligand self-association induced by DNA for the interactions of the natural alkaloids berberine and sanguinarine with the human telomeric G-quadruplex DNA.
@article{Bessi2012,
title = {Spectroscopic, Molecular Modeling, and {{NMR-spectroscopic}} Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric {{G-quadruplex DNA}}.},
author = {Bessi, Irene and Bazzicalupi, Carla and Richter, Christian and a Jonker, Hendrik R and Saxena, Krishna and Sissi, Claudia and Chioccioli, Matteo and Bianco, Sara and Bilia, Anna Rita and Schwalbe, Harald and Gratteri, Paola},
year = {2012},
month = jun,
journal = {ACS chemical biology},
volume = {7},
number = {6},
eprint = {22486369},
eprinttype = {pubmed},
pages = {1109--19},
issn = {1554-8937},
doi = {10.1021/cb300096g},
abstract = {G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA, and ligands able to stabilize this structure have recently been identified as potential anticancer drugs. Among the potential G-quadruplex binders, we have studied the binding ability of berberine and sanguinarine, two members of the alkaloid family, an important class of natural products long known for medicinal purpose. Our spectroscopic (CD, NMR, and fluorescence) studies and molecular modeling approaches revealed binding modes at ligand-complex stoichiometries {\textquestiondown}1:1 and ligand self-association induced by DNA for the interactions of the natural alkaloids berberine and sanguinarine with the human telomeric G-quadruplex DNA.},
pmid = {22486369},
keywords = {\#nosource}
}
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R.","Schwalbe, H.","Gratteri, P."],"bibdata":{"bibtype":"article","type":"article","title":"Spectroscopic, Molecular Modeling, and NMR-spectroscopic Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric G-quadruplex DNA.","author":[{"propositions":[],"lastnames":["Bessi"],"firstnames":["Irene"],"suffixes":[]},{"propositions":[],"lastnames":["Bazzicalupi"],"firstnames":["Carla"],"suffixes":[]},{"propositions":[],"lastnames":["Richter"],"firstnames":["Christian"],"suffixes":[]},{"propositions":["a"],"lastnames":["Jonker"],"firstnames":["Hendrik","R"],"suffixes":[]},{"propositions":[],"lastnames":["Saxena"],"firstnames":["Krishna"],"suffixes":[]},{"propositions":[],"lastnames":["Sissi"],"firstnames":["Claudia"],"suffixes":[]},{"propositions":[],"lastnames":["Chioccioli"],"firstnames":["Matteo"],"suffixes":[]},{"propositions":[],"lastnames":["Bianco"],"firstnames":["Sara"],"suffixes":[]},{"propositions":[],"lastnames":["Bilia"],"firstnames":["Anna","Rita"],"suffixes":[]},{"propositions":[],"lastnames":["Schwalbe"],"firstnames":["Harald"],"suffixes":[]},{"propositions":[],"lastnames":["Gratteri"],"firstnames":["Paola"],"suffixes":[]}],"year":"2012","month":"June","journal":"ACS chemical biology","volume":"7","number":"6","eprint":"22486369","eprinttype":"pubmed","pages":"1109–19","issn":"1554-8937","doi":"10.1021/cb300096g","abstract":"G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA, and ligands able to stabilize this structure have recently been identified as potential anticancer drugs. Among the potential G-quadruplex binders, we have studied the binding ability of berberine and sanguinarine, two members of the alkaloid family, an important class of natural products long known for medicinal purpose. Our spectroscopic (CD, NMR, and fluorescence) studies and molecular modeling approaches revealed binding modes at ligand-complex stoichiometries ¿1:1 and ligand self-association induced by DNA for the interactions of the natural alkaloids berberine and sanguinarine with the human telomeric G-quadruplex DNA.","pmid":"22486369","keywords":"#nosource","bibtex":"@article{Bessi2012,\n title = {Spectroscopic, Molecular Modeling, and {{NMR-spectroscopic}} Investigation of the Binding Mode of the Natural Alkaloids Berberine and Sanguinarine to Human Telomeric {{G-quadruplex DNA}}.},\n author = {Bessi, Irene and Bazzicalupi, Carla and Richter, Christian and a Jonker, Hendrik R and Saxena, Krishna and Sissi, Claudia and Chioccioli, Matteo and Bianco, Sara and Bilia, Anna Rita and Schwalbe, Harald and Gratteri, Paola},\n year = {2012},\n month = jun,\n journal = {ACS chemical biology},\n volume = {7},\n number = {6},\n eprint = {22486369},\n eprinttype = {pubmed},\n pages = {1109--19},\n issn = {1554-8937},\n doi = {10.1021/cb300096g},\n abstract = {G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA, and ligands able to stabilize this structure have recently been identified as potential anticancer drugs. 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