In Vitro Cell Cultures Obtained from Different Explants of Corylus Avellana Produce Taxol and Taxanes. Bestoso, F.; Ottaggio, L.; Armirotti, A.; Balbi, A.; Damonte, G.; Degan, P.; Mazzei, M.; Cavalli, F.; Ledda, B.; and Miele, M. 6(1):45+.
In Vitro Cell Cultures Obtained from Different Explants of Corylus Avellana Produce Taxol and Taxanes [link]Paper  doi  abstract   bibtex   
Taxol is an effective antineoplastic agent, originally extracted from the bark of Taxus brevifolia with a low yield. Many attempts have been made to produce Taxol by chemical synthesis, semi-synthesis and plant tissue cultures. However, to date, the availability of this compound is not sufficient to satisfy the commercial requirements. The aim of the present work was to produce suspension cell cultures from plants not belonging to Taxus genus and to verify whether they produced Taxol and taxanes. For this purpose different explants of hazel (Corylus avellana species) were used to optimize the protocol for inducing in vitro callus, an undifferentiated tissue from which suspension cell cultures were established.
@article{bestosoVitroCellCultures2006,
  title = {In Vitro Cell Cultures Obtained from Different Explants of {{Corylus}} Avellana Produce {{Taxol}} and Taxanes},
  author = {Bestoso, F. and Ottaggio, L. and Armirotti, A. and Balbi, A. and Damonte, G. and Degan, P. and Mazzei, M. and Cavalli, F. and Ledda, B. and Miele, M.},
  date = {2006-12},
  journaltitle = {BMC Biotechnology},
  volume = {6},
  pages = {45+},
  issn = {1472-6750},
  doi = {10.1186/1472-6750-6-45},
  url = {https://doi.org/10.1186/1472-6750-6-45},
  abstract = {Taxol is an effective antineoplastic agent, originally extracted from the bark of Taxus brevifolia with a low yield. Many attempts have been made to produce Taxol by chemical synthesis, semi-synthesis and plant tissue cultures. However, to date, the availability of this compound is not sufficient to satisfy the commercial requirements. The aim of the present work was to produce suspension cell cultures from plants not belonging to Taxus genus and to verify whether they produced Taxol and taxanes. For this purpose different explants of hazel (Corylus avellana species) were used to optimize the protocol for inducing in vitro callus, an undifferentiated tissue from which suspension cell cultures were established.},
  keywords = {*imported-from-citeulike-INRMM,~INRMM-MiD:c-976862,corylus-avellana,forest-resources,in-vitro-culture,taxol},
  number = {1}
}
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