@article{betton_biomarkers_2012,
	title = {Biomarkers of collecting duct injury in {Han}-{Wistar} and {Sprague}-{Dawley} rats treated with {N}-phenylanthranilic {Acid}},
	volume = {40},
	issn = {1533-1601},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22301952},
	doi = {10.1177/0192623311436174},
	abstract = {N-phenylanthranilic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Studies were conducted in two strains of male rats to evaluate novel biomarkers of nephrotoxicity. Han-Wistar rats were given daily oral doses of 50, 350, or up to 700 mg/kg/day of NPAA, and Sprague-Dawley rats were given 50 or 400 mg/kg/day of NPAA. Rats were euthanized on days 8 and 15. The candidate kidney injury biomarkers renal papillary antigen-1 (RPA-1, for collecting duct injury), clusterin (for general kidney injury), α-glutathione-S-transferase (a proximal tubular marker), and µ-glutathione-S-transferase (a distal tubular marker) were measured in urine by enzyme immunoassay. Characteristic degeneration and necrosis of the collecting duct and renal papilla were observed in Han-Wistar rats at the high dose on day 8 and at the mid and high doses on day 15, and in Sprague-Dawley rats given the high dose on days 8 and 15. Increases in urinary RPA-1, and to a lesser extent urine clusterin, were generally associated with the presence of collecting duct injury and were more sensitive than BUN and serum creatinine. On the other hand, decreases in α-glutathione-S-transferase without proximal tubule lesions in both strains and decreases in µ-glutathione-S-transferase in Sprague-Dawley rats only were not associated with morphological proximal or distal tubule abnormalities, so both were of less utility. It was concluded that RPA-1 is a new biomarker with utility in the detection of collecting duct injury in papillary necrosis in male rats.},
	language = {eng},
	number = {4},
	journal = {Toxicologic Pathology},
	author = {Betton, Graham R. and Ennulat, Daniela and Hoffman, David and Gautier, Jean-Charles and Harpur, Ernie and Pettit, Syril},
	month = jun,
	year = {2012},
	pmid = {22301952},
	keywords = {Analysis of Variance, Animals, Biological Markers, Blood Urea Nitrogen, Clusterin, Glutathione Transferase, Histocytochemistry, Kidney Diseases, Kidney Tubules, Collecting, Male, Necrosis, Organ Size, Rats, Rats, Sprague-Dawley, Rats, Wistar, Toxicity Tests, ortho-Aminobenzoates},
	pages = {682--694},
}

{"_id":"3YBZsbGPzEYnvnN23","bibbaseid":"betton-ennulat-hoffman-gautier-harpur-pettit-biomarkersofcollectingductinjuryinhanwistarandspraguedawleyratstreatedwithnphenylanthranilicacid-2012","author_short":["Betton, G. R.","Ennulat, D.","Hoffman, D.","Gautier, J.","Harpur, E.","Pettit, S."],"bibdata":{"bibtype":"article","type":"article","title":"Biomarkers of collecting duct injury in Han-Wistar and Sprague-Dawley rats treated with N-phenylanthranilic Acid","volume":"40","issn":"1533-1601","url":"http://www.ncbi.nlm.nih.gov/pubmed/22301952","doi":"10.1177/0192623311436174","abstract":"N-phenylanthranilic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Studies were conducted in two strains of male rats to evaluate novel biomarkers of nephrotoxicity. Han-Wistar rats were given daily oral doses of 50, 350, or up to 700 mg/kg/day of NPAA, and Sprague-Dawley rats were given 50 or 400 mg/kg/day of NPAA. Rats were euthanized on days 8 and 15. The candidate kidney injury biomarkers renal papillary antigen-1 (RPA-1, for collecting duct injury), clusterin (for general kidney injury), α-glutathione-S-transferase (a proximal tubular marker), and µ-glutathione-S-transferase (a distal tubular marker) were measured in urine by enzyme immunoassay. Characteristic degeneration and necrosis of the collecting duct and renal papilla were observed in Han-Wistar rats at the high dose on day 8 and at the mid and high doses on day 15, and in Sprague-Dawley rats given the high dose on days 8 and 15. Increases in urinary RPA-1, and to a lesser extent urine clusterin, were generally associated with the presence of collecting duct injury and were more sensitive than BUN and serum creatinine. On the other hand, decreases in α-glutathione-S-transferase without proximal tubule lesions in both strains and decreases in µ-glutathione-S-transferase in Sprague-Dawley rats only were not associated with morphological proximal or distal tubule abnormalities, so both were of less utility. It was concluded that RPA-1 is a new biomarker with utility in the detection of collecting duct injury in papillary necrosis in male rats.","language":"eng","number":"4","journal":"Toxicologic Pathology","author":[{"propositions":[],"lastnames":["Betton"],"firstnames":["Graham","R."],"suffixes":[]},{"propositions":[],"lastnames":["Ennulat"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Hoffman"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Gautier"],"firstnames":["Jean-Charles"],"suffixes":[]},{"propositions":[],"lastnames":["Harpur"],"firstnames":["Ernie"],"suffixes":[]},{"propositions":[],"lastnames":["Pettit"],"firstnames":["Syril"],"suffixes":[]}],"month":"June","year":"2012","pmid":"22301952","keywords":"Analysis of Variance, Animals, Biological Markers, Blood Urea Nitrogen, Clusterin, Glutathione Transferase, Histocytochemistry, Kidney Diseases, Kidney Tubules, Collecting, Male, Necrosis, Organ Size, Rats, Rats, Sprague-Dawley, Rats, Wistar, Toxicity Tests, ortho-Aminobenzoates","pages":"682–694","bibtex":"@article{betton_biomarkers_2012,\n\ttitle = {Biomarkers of collecting duct injury in {Han}-{Wistar} and {Sprague}-{Dawley} rats treated with {N}-phenylanthranilic {Acid}},\n\tvolume = {40},\n\tissn = {1533-1601},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/22301952},\n\tdoi = {10.1177/0192623311436174},\n\tabstract = {N-phenylanthranilic acid is a chloride channel blocker that causes renal papillary necrosis in rats. Studies were conducted in two strains of male rats to evaluate novel biomarkers of nephrotoxicity. Han-Wistar rats were given daily oral doses of 50, 350, or up to 700 mg/kg/day of NPAA, and Sprague-Dawley rats were given 50 or 400 mg/kg/day of NPAA. Rats were euthanized on days 8 and 15. The candidate kidney injury biomarkers renal papillary antigen-1 (RPA-1, for collecting duct injury), clusterin (for general kidney injury), α-glutathione-S-transferase (a proximal tubular marker), and µ-glutathione-S-transferase (a distal tubular marker) were measured in urine by enzyme immunoassay. Characteristic degeneration and necrosis of the collecting duct and renal papilla were observed in Han-Wistar rats at the high dose on day 8 and at the mid and high doses on day 15, and in Sprague-Dawley rats given the high dose on days 8 and 15. Increases in urinary RPA-1, and to a lesser extent urine clusterin, were generally associated with the presence of collecting duct injury and were more sensitive than BUN and serum creatinine. On the other hand, decreases in α-glutathione-S-transferase without proximal tubule lesions in both strains and decreases in µ-glutathione-S-transferase in Sprague-Dawley rats only were not associated with morphological proximal or distal tubule abnormalities, so both were of less utility. It was concluded that RPA-1 is a new biomarker with utility in the detection of collecting duct injury in papillary necrosis in male rats.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Toxicologic Pathology},\n\tauthor = {Betton, Graham R. and Ennulat, Daniela and Hoffman, David and Gautier, Jean-Charles and Harpur, Ernie and Pettit, Syril},\n\tmonth = jun,\n\tyear = {2012},\n\tpmid = {22301952},\n\tkeywords = {Analysis of Variance, Animals, Biological Markers, Blood Urea Nitrogen, Clusterin, Glutathione Transferase, Histocytochemistry, Kidney Diseases, Kidney Tubules, Collecting, Male, Necrosis, Organ Size, Rats, Rats, Sprague-Dawley, Rats, Wistar, Toxicity Tests, ortho-Aminobenzoates},\n\tpages = {682--694},\n}\n\n\n\n","author_short":["Betton, G. R.","Ennulat, D.","Hoffman, D.","Gautier, J.","Harpur, E.","Pettit, S."],"key":"betton_biomarkers_2012","id":"betton_biomarkers_2012","bibbaseid":"betton-ennulat-hoffman-gautier-harpur-pettit-biomarkersofcollectingductinjuryinhanwistarandspraguedawleyratstreatedwithnphenylanthranilicacid-2012","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/22301952"},"keyword":["Analysis of Variance","Animals","Biological Markers","Blood Urea Nitrogen","Clusterin","Glutathione Transferase","Histocytochemistry","Kidney Diseases","Kidney Tubules","Collecting","Male","Necrosis","Organ Size","Rats","Rats","Sprague-Dawley","Rats","Wistar","Toxicity Tests","ortho-Aminobenzoates"],"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero-group/kperon/94544","dataSources":["knnrEJWve9PHkHyWX"],"keywords":["analysis of variance","animals","biological markers","blood urea nitrogen","clusterin","glutathione transferase","histocytochemistry","kidney diseases","kidney tubules","collecting","male","necrosis","organ size","rats","rats","sprague-dawley","rats","wistar","toxicity tests","ortho-aminobenzoates"],"search_terms":["biomarkers","collecting","duct","injury","han","wistar","sprague","dawley","rats","treated","phenylanthranilic","acid","betton","ennulat","hoffman","gautier","harpur","pettit"],"title":"Biomarkers of collecting duct injury in Han-Wistar and Sprague-Dawley rats treated with N-phenylanthranilic Acid","year":2012}