Determination of a Large Set of β-Adrenergic Agonists in Animal Matrices Based on Ion Mobility and Mass Separations. Beucher, L.; Dervilly-Pinel, G.; Prévost, S.; Monteau, F.; and Le Bizec, B. 87(18):9234–9242.
Determination of a Large Set of β-Adrenergic Agonists in Animal Matrices Based on Ion Mobility and Mass Separations [link]Paper  doi  abstract   bibtex   
While the coupling of traveling wave ion mobility spectrometry (TWIMS) and mass spectrometry is mainly reported for structural purposes, we studied its potential in enhancing compounds analysis such as growth promoters used in livestock animals at trace concentrations. βAdrenergic agonists have been selected as model compounds since they exhibit a range of close physicochemical properties leading to analytical issues using classical approaches. In this paper, the potential of Synapt G2-S (Q-TWIM-TOF MS) has been investigated for sensitive and specific detection of a range of these synthetic phenethanolamines in various complex biological matrices (retina, meat, and urine) from bovine considered as relevant in the context of detecting β-adrenergic agonists use in animals. In particular, the specificity of the additional information provided by the TWIMS (i.e., collision cross section) together with the interest of the extra dimension of separation is discussed.
@article{beucher_determination_2015,
	title = {Determination of a Large Set of β-Adrenergic Agonists in Animal Matrices Based on Ion Mobility and Mass Separations},
	volume = {87},
	issn = {0003-2700, 1520-6882},
	url = {http://pubs.acs.org/doi/10.1021/acs.analchem.5b01831},
	doi = {10.1021/acs.analchem.5b01831},
	abstract = {While the coupling of traveling wave ion mobility spectrometry ({TWIMS}) and mass spectrometry is mainly reported for structural purposes, we studied its potential in enhancing compounds analysis such as growth promoters used in livestock animals at trace concentrations. βAdrenergic agonists have been selected as model compounds since they exhibit a range of close physicochemical properties leading to analytical issues using classical approaches. In this paper, the potential of Synapt G2-S (Q-{TWIM}-{TOF} {MS}) has been investigated for sensitive and specific detection of a range of these synthetic phenethanolamines in various complex biological matrices (retina, meat, and urine) from bovine considered as relevant in the context of detecting β-adrenergic agonists use in animals. In particular, the specificity of the additional information provided by the {TWIMS} (i.e., collision cross section) together with the interest of the extra dimension of separation is discussed.},
	pages = {9234--9242},
	number = {18},
	journaltitle = {Analytical Chemistry},
	author = {Beucher, Laure and Dervilly-Pinel, Gaud and Prévost, Stéphanie and Monteau, Fabrice and Le Bizec, Bruno},
	urldate = {2019-03-29},
	date = {2015-09-15},
	langid = {english},
	file = {Beucher et al. - 2015 - Determination of a Large Set of β-Adrenergic Agoni.pdf:C\:\\Users\\ygu\\Documents\\PCPOR066_YGU\\YGU\\Zotero\\storage\\G74WRU5V\\Beucher et al. - 2015 - Determination of a Large Set of β-Adrenergic Agoni.pdf:application/pdf}
}
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