Registration on the renal transplantation waiting list and mortality on dialysis: an analysis of the French REIN registry using a multi-state model. Beuscart, J., Pagniez, D., Boulanger, E., & Duhamel, A. Journal of Epidemiology / Japan Epidemiological Association, 25(2):133–141, 2015. doi abstract bibtex BACKGROUND: Access to the renal transplantation (RT) waiting list depends on factors related to lower mortality rates and often occurs after dialysis initiation. The aim of the study was to use a flexible regression model to determine if registration on the RT waiting list is associated with mortality on dialysis, independent of the comorbidities associated with such registration. METHODS: Data from the French REIN registry on 7138 incident hemodialysis (HD) patients were analyzed. A multi-state model including four states ('HD, not wait-listed', 'HD, wait-listed', 'death', and 'RT') was used to estimate the effect of being wait-listed on the probability of death. RESULTS: During the study, 1392 (19.5%) patients were wait-listed. Of the 2954 deaths observed in the entire cohort during follow-up, 2921 (98.9%) were observed in the not wait-listed group compared with only 33 (1.1%) in the wait-listed group. In the multivariable analysis, the adjusted hazard ratio for death associated with non-registration on the waiting list was 3.52 (95% CI, 1.70-7.30). The risk factors for death identified for not wait-listed patients were not found to be significant risk factors for wait-listed patients, with the exception of age. CONCLUSIONS: The use of a multi-state model allowed a flexible analysis of mortality on dialysis. Patients who were not wait-listed had a much higher risk of death, regardless of co-morbidities associated with being wait-listed, and did not share the same risk factors of death as wait-listed patients. Registration on the waiting list should therefore be taken into account in survival analysis of patients on dialysis.
@article{beuscart_registration_2015,
title = {Registration on the renal transplantation waiting list and mortality on dialysis: an analysis of the {French} {REIN} registry using a multi-state model},
volume = {25},
issn = {1349-9092},
shorttitle = {Registration on the renal transplantation waiting list and mortality on dialysis},
doi = {10.2188/jea.JE20130193},
abstract = {BACKGROUND: Access to the renal transplantation (RT) waiting list depends on factors related to lower mortality rates and often occurs after dialysis initiation. The aim of the study was to use a flexible regression model to determine if registration on the RT waiting list is associated with mortality on dialysis, independent of the comorbidities associated with such registration.
METHODS: Data from the French REIN registry on 7138 incident hemodialysis (HD) patients were analyzed. A multi-state model including four states ('HD, not wait-listed', 'HD, wait-listed', 'death', and 'RT') was used to estimate the effect of being wait-listed on the probability of death.
RESULTS: During the study, 1392 (19.5\%) patients were wait-listed. Of the 2954 deaths observed in the entire cohort during follow-up, 2921 (98.9\%) were observed in the not wait-listed group compared with only 33 (1.1\%) in the wait-listed group. In the multivariable analysis, the adjusted hazard ratio for death associated with non-registration on the waiting list was 3.52 (95\% CI, 1.70-7.30). The risk factors for death identified for not wait-listed patients were not found to be significant risk factors for wait-listed patients, with the exception of age.
CONCLUSIONS: The use of a multi-state model allowed a flexible analysis of mortality on dialysis. Patients who were not wait-listed had a much higher risk of death, regardless of co-morbidities associated with being wait-listed, and did not share the same risk factors of death as wait-listed patients. Registration on the waiting list should therefore be taken into account in survival analysis of patients on dialysis.},
language = {eng},
number = {2},
journal = {Journal of Epidemiology / Japan Epidemiological Association},
author = {Beuscart, Jean-Baptiste and Pagniez, Dominique and Boulanger, Eric and Duhamel, Alain},
year = {2015},
pmid = {25721069},
pmcid = {PMC4310874},
pages = {133--141},
}
Downloads: 0
{"_id":"4MfQd2FmqDHvRjJqG","bibbaseid":"beuscart-pagniez-boulanger-duhamel-registrationontherenaltransplantationwaitinglistandmortalityondialysisananalysisofthefrenchreinregistryusingamultistatemodel-2015","author_short":["Beuscart, J.","Pagniez, D.","Boulanger, E.","Duhamel, A."],"bibdata":{"bibtype":"article","type":"article","title":"Registration on the renal transplantation waiting list and mortality on dialysis: an analysis of the French REIN registry using a multi-state model","volume":"25","issn":"1349-9092","shorttitle":"Registration on the renal transplantation waiting list and mortality on dialysis","doi":"10.2188/jea.JE20130193","abstract":"BACKGROUND: Access to the renal transplantation (RT) waiting list depends on factors related to lower mortality rates and often occurs after dialysis initiation. The aim of the study was to use a flexible regression model to determine if registration on the RT waiting list is associated with mortality on dialysis, independent of the comorbidities associated with such registration. METHODS: Data from the French REIN registry on 7138 incident hemodialysis (HD) patients were analyzed. A multi-state model including four states ('HD, not wait-listed', 'HD, wait-listed', 'death', and 'RT') was used to estimate the effect of being wait-listed on the probability of death. RESULTS: During the study, 1392 (19.5%) patients were wait-listed. Of the 2954 deaths observed in the entire cohort during follow-up, 2921 (98.9%) were observed in the not wait-listed group compared with only 33 (1.1%) in the wait-listed group. In the multivariable analysis, the adjusted hazard ratio for death associated with non-registration on the waiting list was 3.52 (95% CI, 1.70-7.30). The risk factors for death identified for not wait-listed patients were not found to be significant risk factors for wait-listed patients, with the exception of age. CONCLUSIONS: The use of a multi-state model allowed a flexible analysis of mortality on dialysis. Patients who were not wait-listed had a much higher risk of death, regardless of co-morbidities associated with being wait-listed, and did not share the same risk factors of death as wait-listed patients. Registration on the waiting list should therefore be taken into account in survival analysis of patients on dialysis.","language":"eng","number":"2","journal":"Journal of Epidemiology / Japan Epidemiological Association","author":[{"propositions":[],"lastnames":["Beuscart"],"firstnames":["Jean-Baptiste"],"suffixes":[]},{"propositions":[],"lastnames":["Pagniez"],"firstnames":["Dominique"],"suffixes":[]},{"propositions":[],"lastnames":["Boulanger"],"firstnames":["Eric"],"suffixes":[]},{"propositions":[],"lastnames":["Duhamel"],"firstnames":["Alain"],"suffixes":[]}],"year":"2015","pmid":"25721069","pmcid":"PMC4310874","pages":"133–141","bibtex":"@article{beuscart_registration_2015,\n\ttitle = {Registration on the renal transplantation waiting list and mortality on dialysis: an analysis of the {French} {REIN} registry using a multi-state model},\n\tvolume = {25},\n\tissn = {1349-9092},\n\tshorttitle = {Registration on the renal transplantation waiting list and mortality on dialysis},\n\tdoi = {10.2188/jea.JE20130193},\n\tabstract = {BACKGROUND: Access to the renal transplantation (RT) waiting list depends on factors related to lower mortality rates and often occurs after dialysis initiation. The aim of the study was to use a flexible regression model to determine if registration on the RT waiting list is associated with mortality on dialysis, independent of the comorbidities associated with such registration.\nMETHODS: Data from the French REIN registry on 7138 incident hemodialysis (HD) patients were analyzed. A multi-state model including four states ('HD, not wait-listed', 'HD, wait-listed', 'death', and 'RT') was used to estimate the effect of being wait-listed on the probability of death.\nRESULTS: During the study, 1392 (19.5\\%) patients were wait-listed. Of the 2954 deaths observed in the entire cohort during follow-up, 2921 (98.9\\%) were observed in the not wait-listed group compared with only 33 (1.1\\%) in the wait-listed group. In the multivariable analysis, the adjusted hazard ratio for death associated with non-registration on the waiting list was 3.52 (95\\% CI, 1.70-7.30). The risk factors for death identified for not wait-listed patients were not found to be significant risk factors for wait-listed patients, with the exception of age.\nCONCLUSIONS: The use of a multi-state model allowed a flexible analysis of mortality on dialysis. Patients who were not wait-listed had a much higher risk of death, regardless of co-morbidities associated with being wait-listed, and did not share the same risk factors of death as wait-listed patients. Registration on the waiting list should therefore be taken into account in survival analysis of patients on dialysis.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Epidemiology / Japan Epidemiological Association},\n\tauthor = {Beuscart, Jean-Baptiste and Pagniez, Dominique and Boulanger, Eric and Duhamel, Alain},\n\tyear = {2015},\n\tpmid = {25721069},\n\tpmcid = {PMC4310874},\n\tpages = {133--141},\n}\n\n","author_short":["Beuscart, J.","Pagniez, D.","Boulanger, E.","Duhamel, A."],"key":"beuscart_registration_2015","id":"beuscart_registration_2015","bibbaseid":"beuscart-pagniez-boulanger-duhamel-registrationontherenaltransplantationwaitinglistandmortalityondialysisananalysisofthefrenchreinregistryusingamultistatemodel-2015","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/576834/collections/NYCBQQBB/items?key=MJNBdUsYThALl7viNVVbkecN&format=bibtex&limit=100","dataSources":["KcAAuaxski6XBszw2"],"keywords":[],"search_terms":["registration","renal","transplantation","waiting","list","mortality","dialysis","analysis","french","rein","registry","using","multi","state","model","beuscart","pagniez","boulanger","duhamel"],"title":"Registration on the renal transplantation waiting list and mortality on dialysis: an analysis of the French REIN registry using a multi-state model","year":2015}