Bottlebrush Glycopolymers from 2-Oxazolines and Acrylamides for Targeting Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin and Mannose-Binding Lectin. Beyer, V. P., Monaco, A., Napier, R., Yilmaz, G., & Becer, C. R. BIOMACROMOLECULES, 21(6):2298–2308, June, 2020. doi abstract bibtex Lectins are omnipresent carbohydrate binding proteins that are involved in a multitude of biological processes. Unearthing their binding properties is a powerful tool toward the understanding and modification of their functions in biological applications. Herein, we present the synthesis of glycopolymers with a brush architecture via a "grafting from" methodology. The use of a versatile 2-oxazoline inimer was demonstrated to open avenues for a wide range of 2-oxazoline/acrylamide bottle brush polymers utilizing aqueous Cu-mediated reversible deactivation radical polymerization (Cu-RDRP). The polymers in the obtained library were assessed for their thermal properties in aqueous solution and their binding toward the C-type animal lectins dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin DC-SIGN) and mannose-binding lectin (MBL) via surface plasmon resonance spectrometry. The encapsulation properties of a hydrophobic drug-mimicking compound demonstrated the potential use of glyco brush copolymers in biological applications.
@article{beyer_bottlebrush_2020,
title = {Bottlebrush {Glycopolymers} from 2-{Oxazolines} and {Acrylamides} for {Targeting} {Dendritic} {Cell}-{Specific} {Intercellular} {Adhesion} {Molecule}-3-{Grabbing} {Nonintegrin} and {Mannose}-{Binding} {Lectin}},
volume = {21},
issn = {1525-7797},
doi = {10.1021/acs.biomac.0c00246},
abstract = {Lectins are omnipresent carbohydrate binding proteins that are involved in a multitude of biological processes. Unearthing their binding properties is a powerful tool toward the understanding and modification of their functions in biological applications. Herein, we present the synthesis of glycopolymers with a brush architecture via a "grafting from" methodology. The use of a versatile 2-oxazoline inimer was demonstrated to open avenues for a wide range of 2-oxazoline/acrylamide bottle brush polymers utilizing aqueous Cu-mediated reversible deactivation radical polymerization (Cu-RDRP). The polymers in the obtained library were assessed for their thermal properties in aqueous solution and their binding toward the C-type animal lectins dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin DC-SIGN) and mannose-binding lectin (MBL) via surface plasmon resonance spectrometry. The encapsulation properties of a hydrophobic drug-mimicking compound demonstrated the potential use of glyco brush copolymers in biological applications.},
number = {6},
urldate = {2020-07-07},
journal = {BIOMACROMOLECULES},
author = {Beyer, Valentin P. and Monaco, Alessandra and Napier, Richard and Yilmaz, Gokhan and Becer, C. Remzi},
month = jun,
year = {2020},
pages = {2298--2308},
}
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