@ARTICLE{Bhaduri2020-pa,
  title    = "Outer Radial Glia-like Cancer Stem Cells Contribute to
              Heterogeneity of Glioblastoma",
  author   = "Bhaduri, Aparna and Di Lullo, Elizabeth and Jung, Diane and
              M{\"u}ller, S{\"o}ren and Crouch, Elizabeth Erin and Espinosa,
              Carmen Sandoval and Ozawa, Tomoko and Alvarado, Beatriz and
              Spatazza, Julien and Cadwell, Cathryn Ren{\'e} and Wilkins, Grace
              and Velmeshev, Dmitry and Liu, Siyuan John and Malatesta, Martina
              and Andrews, Madeline Gail and Mostajo-Radji, Mohammed Andres and
              Huang, Eric Jinsheng and Nowakowski, Tomasz Jan and Lim, Daniel
              Amos and Diaz, Aaron and Raleigh, David Ronan and Kriegstein,
              Arnold Richard",
  abstract = "Glioblastoma is a devastating form of brain cancer. To identify
              aspects of tumor heterogeneity that may illuminate drivers of
              tumor invasion, we created a glioblastoma tumor cell atlas with
              single-cell transcriptomics of cancer cells mapped onto a
              reference framework of the developing and adult human brain. We
              find that multiple GSC subtypes exist within a single tumor.
              Within these GSCs, we identify an invasive cell population
              similar to outer radial glia (oRG), a fetal cell type that
              expands the stem cell niche in normal human cortex. Using live
              time-lapse imaging of primary resected tumors, we discover that
              tumor-derived oRG-like cells undergo characteristic mitotic somal
              translocation behavior previously only observed in human
              development, suggesting a reactivation of developmental programs.
              In addition, we show that PTPRZ1 mediates both mitotic somal
              translocation and glioblastoma tumor invasion. These data suggest
              that the presence of heterogeneous GSCs may underlie
              glioblastoma's rapid progression and invasion.",
  journal  = "Cell Stem Cell",
  volume   =  26,
  number   =  1,
  pages    = "48--63.e6",
  month    =  jan,
  year     =  2020,
  keywords = "cancer stem cell; glioblastoma; outer radial glia; single-cell
              sequencing; tumor heterogeneity",
  language = "en"
}

{"_id":"uhnmMjBAfLxAPTQJJ","bibbaseid":"bhaduri-dilullo-jung-mller-crouch-espinosa-ozawa-alvarado-etal-outerradialglialikecancerstemcellscontributetoheterogeneityofglioblastoma-2020","author_short":["Bhaduri, A.","Di Lullo, E.","Jung, D.","Müller, S.","Crouch, E. E.","Espinosa, C. S.","Ozawa, T.","Alvarado, B.","Spatazza, J.","Cadwell, C. R.","Wilkins, G.","Velmeshev, D.","Liu, S. J.","Malatesta, M.","Andrews, M. G.","Mostajo-Radji, M. A.","Huang, E. J.","Nowakowski, T. J.","Lim, D. A.","Diaz, A.","Raleigh, D. R.","Kriegstein, A. R."],"bibdata":{"bibtype":"article","type":"article","title":"Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma","author":[{"propositions":[],"lastnames":["Bhaduri"],"firstnames":["Aparna"],"suffixes":[]},{"propositions":[],"lastnames":["Di","Lullo"],"firstnames":["Elizabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Jung"],"firstnames":["Diane"],"suffixes":[]},{"propositions":[],"lastnames":["Müller"],"firstnames":["Sören"],"suffixes":[]},{"propositions":[],"lastnames":["Crouch"],"firstnames":["Elizabeth","Erin"],"suffixes":[]},{"propositions":[],"lastnames":["Espinosa"],"firstnames":["Carmen","Sandoval"],"suffixes":[]},{"propositions":[],"lastnames":["Ozawa"],"firstnames":["Tomoko"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarado"],"firstnames":["Beatriz"],"suffixes":[]},{"propositions":[],"lastnames":["Spatazza"],"firstnames":["Julien"],"suffixes":[]},{"propositions":[],"lastnames":["Cadwell"],"firstnames":["Cathryn","René"],"suffixes":[]},{"propositions":[],"lastnames":["Wilkins"],"firstnames":["Grace"],"suffixes":[]},{"propositions":[],"lastnames":["Velmeshev"],"firstnames":["Dmitry"],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["Siyuan","John"],"suffixes":[]},{"propositions":[],"lastnames":["Malatesta"],"firstnames":["Martina"],"suffixes":[]},{"propositions":[],"lastnames":["Andrews"],"firstnames":["Madeline","Gail"],"suffixes":[]},{"propositions":[],"lastnames":["Mostajo-Radji"],"firstnames":["Mohammed","Andres"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Eric","Jinsheng"],"suffixes":[]},{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","Jan"],"suffixes":[]},{"propositions":[],"lastnames":["Lim"],"firstnames":["Daniel","Amos"],"suffixes":[]},{"propositions":[],"lastnames":["Diaz"],"firstnames":["Aaron"],"suffixes":[]},{"propositions":[],"lastnames":["Raleigh"],"firstnames":["David","Ronan"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","Richard"],"suffixes":[]}],"abstract":"Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor cell atlas with single-cell transcriptomics of cancer cells mapped onto a reference framework of the developing and adult human brain. We find that multiple GSC subtypes exist within a single tumor. Within these GSCs, we identify an invasive cell population similar to outer radial glia (oRG), a fetal cell type that expands the stem cell niche in normal human cortex. Using live time-lapse imaging of primary resected tumors, we discover that tumor-derived oRG-like cells undergo characteristic mitotic somal translocation behavior previously only observed in human development, suggesting a reactivation of developmental programs. In addition, we show that PTPRZ1 mediates both mitotic somal translocation and glioblastoma tumor invasion. These data suggest that the presence of heterogeneous GSCs may underlie glioblastoma's rapid progression and invasion.","journal":"Cell Stem Cell","volume":"26","number":"1","pages":"48–63.e6","month":"January","year":"2020","keywords":"cancer stem cell; glioblastoma; outer radial glia; single-cell sequencing; tumor heterogeneity","language":"en","bibtex":"@ARTICLE{Bhaduri2020-pa,\n title = \"Outer Radial Glia-like Cancer Stem Cells Contribute to\n Heterogeneity of Glioblastoma\",\n author = \"Bhaduri, Aparna and Di Lullo, Elizabeth and Jung, Diane and\n M{\\\"u}ller, S{\\\"o}ren and Crouch, Elizabeth Erin and Espinosa,\n Carmen Sandoval and Ozawa, Tomoko and Alvarado, Beatriz and\n Spatazza, Julien and Cadwell, Cathryn Ren{\\'e} and Wilkins, Grace\n and Velmeshev, Dmitry and Liu, Siyuan John and Malatesta, Martina\n and Andrews, Madeline Gail and Mostajo-Radji, Mohammed Andres and\n Huang, Eric Jinsheng and Nowakowski, Tomasz Jan and Lim, Daniel\n Amos and Diaz, Aaron and Raleigh, David Ronan and Kriegstein,\n Arnold Richard\",\n abstract = \"Glioblastoma is a devastating form of brain cancer. To identify\n aspects of tumor heterogeneity that may illuminate drivers of\n tumor invasion, we created a glioblastoma tumor cell atlas with\n single-cell transcriptomics of cancer cells mapped onto a\n reference framework of the developing and adult human brain. We\n find that multiple GSC subtypes exist within a single tumor.\n Within these GSCs, we identify an invasive cell population\n similar to outer radial glia (oRG), a fetal cell type that\n expands the stem cell niche in normal human cortex. Using live\n time-lapse imaging of primary resected tumors, we discover that\n tumor-derived oRG-like cells undergo characteristic mitotic somal\n translocation behavior previously only observed in human\n development, suggesting a reactivation of developmental programs.\n In addition, we show that PTPRZ1 mediates both mitotic somal\n translocation and glioblastoma tumor invasion. These data suggest\n that the presence of heterogeneous GSCs may underlie\n glioblastoma's rapid progression and invasion.\",\n journal = \"Cell Stem Cell\",\n volume = 26,\n number = 1,\n pages = \"48--63.e6\",\n month = jan,\n year = 2020,\n keywords = \"cancer stem cell; glioblastoma; outer radial glia; single-cell\n sequencing; tumor heterogeneity\",\n language = \"en\"\n}\n\n","author_short":["Bhaduri, A.","Di Lullo, E.","Jung, D.","Müller, S.","Crouch, E. E.","Espinosa, C. S.","Ozawa, T.","Alvarado, B.","Spatazza, J.","Cadwell, C. R.","Wilkins, G.","Velmeshev, D.","Liu, S. J.","Malatesta, M.","Andrews, M. G.","Mostajo-Radji, M. A.","Huang, E. J.","Nowakowski, T. J.","Lim, D. A.","Diaz, A.","Raleigh, D. R.","Kriegstein, A. R."],"key":"Bhaduri2020-pa","id":"Bhaduri2020-pa","bibbaseid":"bhaduri-dilullo-jung-mller-crouch-espinosa-ozawa-alvarado-etal-outerradialglialikecancerstemcellscontributetoheterogeneityofglioblastoma-2020","role":"author","urls":{},"keyword":["cancer stem cell; glioblastoma; outer radial glia; single-cell sequencing; tumor heterogeneity"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":["cancer stem cell; glioblastoma; outer radial glia; single-cell sequencing; tumor heterogeneity"],"search_terms":["outer","radial","glia","cancer","stem","cells","contribute","heterogeneity","glioblastoma","bhaduri","di lullo","jung","müller","crouch","espinosa","ozawa","alvarado","spatazza","cadwell","wilkins","velmeshev","liu","malatesta","andrews","mostajo-radji","huang","nowakowski","lim","diaz","raleigh","kriegstein"],"title":"Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma","year":2020}