@ARTICLE{Bhaduri2021-ch,
  title    = "Identification of Lipid Heterogeneity and Diversity in the
              Developing Human Brain",
  author   = "Bhaduri, Aparna and Neumann, Elizabeth K and Kriegstein, Arnold R
              and Sweedler, Jonathan V",
  abstract = "The lipidome is currently understudied but fundamental to life.
              Within the brain, little is known about cell-type lipid
              heterogeneity, and even less is known about cell-to-cell lipid
              diversity because it is difficult to study the lipids within
              individual cells. Here, we used single-cell mass
              spectrometry-based protocols to profile the lipidomes of 154 910
              single cells across ten individuals consisting of five
              developmental ages and five brain regions, resulting in a unique
              lipid atlas available via a web browser of the developing human
              brain. From these data, we identify differentially expressed
              lipids across brain structures, cortical areas, and developmental
              ages. We inferred lipid profiles of several major cell types from
              this data set and additionally detected putative cell-type
              specific lipids. This data set will enable further interrogation
              of the developing human brain lipidome.",
  journal  = "JACS Au",
  volume   =  1,
  number   =  12,
  pages    = "2261--2270",
  month    =  nov,
  year     =  2021,
  language = "en"
}

{"_id":"3S4ePGjs4hJmpsu9Q","bibbaseid":"bhaduri-neumann-kriegstein-sweedler-identificationoflipidheterogeneityanddiversityinthedevelopinghumanbrain-2021","author_short":["Bhaduri, A.","Neumann, E. K","Kriegstein, A. R","Sweedler, J. V"],"bibdata":{"bibtype":"article","type":"article","title":"Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain","author":[{"propositions":[],"lastnames":["Bhaduri"],"firstnames":["Aparna"],"suffixes":[]},{"propositions":[],"lastnames":["Neumann"],"firstnames":["Elizabeth","K"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Sweedler"],"firstnames":["Jonathan","V"],"suffixes":[]}],"abstract":"The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, and even less is known about cell-to-cell lipid diversity because it is difficult to study the lipids within individual cells. Here, we used single-cell mass spectrometry-based protocols to profile the lipidomes of 154 910 single cells across ten individuals consisting of five developmental ages and five brain regions, resulting in a unique lipid atlas available via a web browser of the developing human brain. From these data, we identify differentially expressed lipids across brain structures, cortical areas, and developmental ages. We inferred lipid profiles of several major cell types from this data set and additionally detected putative cell-type specific lipids. This data set will enable further interrogation of the developing human brain lipidome.","journal":"JACS Au","volume":"1","number":"12","pages":"2261–2270","month":"November","year":"2021","language":"en","bibtex":"@ARTICLE{Bhaduri2021-ch,\n title = \"Identification of Lipid Heterogeneity and Diversity in the\n Developing Human Brain\",\n author = \"Bhaduri, Aparna and Neumann, Elizabeth K and Kriegstein, Arnold R\n and Sweedler, Jonathan V\",\n abstract = \"The lipidome is currently understudied but fundamental to life.\n Within the brain, little is known about cell-type lipid\n heterogeneity, and even less is known about cell-to-cell lipid\n diversity because it is difficult to study the lipids within\n individual cells. Here, we used single-cell mass\n spectrometry-based protocols to profile the lipidomes of 154 910\n single cells across ten individuals consisting of five\n developmental ages and five brain regions, resulting in a unique\n lipid atlas available via a web browser of the developing human\n brain. From these data, we identify differentially expressed\n lipids across brain structures, cortical areas, and developmental\n ages. We inferred lipid profiles of several major cell types from\n this data set and additionally detected putative cell-type\n specific lipids. This data set will enable further interrogation\n of the developing human brain lipidome.\",\n journal = \"JACS Au\",\n volume = 1,\n number = 12,\n pages = \"2261--2270\",\n month = nov,\n year = 2021,\n language = \"en\"\n}\n\n","author_short":["Bhaduri, A.","Neumann, E. K","Kriegstein, A. R","Sweedler, J. V"],"key":"Bhaduri2021-ch","id":"Bhaduri2021-ch","bibbaseid":"bhaduri-neumann-kriegstein-sweedler-identificationoflipidheterogeneityanddiversityinthedevelopinghumanbrain-2021","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["identification","lipid","heterogeneity","diversity","developing","human","brain","bhaduri","neumann","kriegstein","sweedler"],"title":"Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain","year":2021}