Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants. Bhattarai, A. Ph.D. Thesis, Univeristät Duisburg-Essen, Essen, 2019. ZSCC: NoCitationData[s0] ![Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Female pelvic floor dysfunctions (PFDs) such as incontinence and prolapse are observed in multiparous elderly females caused by denervation injuries during childbirth and progressive tissue remodeling after menopause. With continuously increasing average life expectancy, these disorders have become an important public health issue that require high costs for the treatment and a standardized study. Minimally invasive surgery has become a more frequent repair procedure for which more than 20 million implants are implanted worldwide every year. However, serious postoperative mesh relative complications are reported. This thesis reviews the static, functional and dynamic anatomy of the female pelvic floor. A detail methodology to construct a realistic computer model from sheet plastination of a female cadaver pelvic floor has been described. Based on the published literature and multi-disciplinary communication with surgeons and urologist, a most complete form of 3D finite element (FE) model has been constructed, which considers smoothed NURBS based surfaces for frictionless contacts between organs and internal self-contact of the hollow organs. Further, an isotropic, hyperelastic, incompressible multiscale modeling of the soft connective tissues is adopted. In addition, transversely isotropic and non-linear Humphrey's constitutive model has been implemented to describe the passive stretching of the pelvic skeletal muscle without neural excitation. Similarly, for the experimented surgical meshes with different pore characteristics and stress-strain curves, linearly elastic orthotropic and non-linear hyperelastic models are fitted and used in the numerical study. Various FE analyses are performed to investigate pathophysiological situations and surgical treatments using mesh implants to compare their biofunctionality and to optimize the preferred surgery. Hence, the presented models and the modeling approaches included in this thesis facilitate the work of surgeons and urologists by a biomechanical study of female PFDs.
@phdthesis{bhattarai_constitutive_2019,
address = {Essen},
type = {Dr.-{Ing}. {Dissertation}},
title = {Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants},
copyright = {Alle Rechte vorbehalten},
url = {https://duepublico2.uni-due.de/receive/duepublico_mods_00070340},
abstract = {Female pelvic floor dysfunctions (PFDs) such as incontinence and prolapse are observed in multiparous elderly females caused by denervation injuries during childbirth and progressive tissue remodeling after menopause. With continuously increasing average life expectancy, these disorders have become an important public health issue that require high costs for the treatment and a standardized study. Minimally invasive surgery has become a more frequent repair procedure for which more than 20 million implants are implanted worldwide every year. However, serious postoperative mesh relative complications are reported.
This thesis reviews the static, functional and dynamic anatomy of the female pelvic floor. A detail methodology to construct a realistic computer model from sheet plastination of a female cadaver pelvic floor has been described. Based on the published literature and multi-disciplinary communication with surgeons and urologist, a most complete form of 3D finite element (FE) model has been constructed, which considers smoothed NURBS based surfaces for frictionless contacts between organs and internal self-contact of the hollow organs. Further, an isotropic, hyperelastic, incompressible multiscale modeling of the soft connective tissues is adopted. In addition, transversely isotropic and non-linear Humphrey's constitutive model has been implemented to describe the passive stretching of the pelvic skeletal muscle without neural excitation. Similarly, for the experimented surgical meshes with different pore characteristics and stress-strain curves, linearly elastic orthotropic and non-linear hyperelastic models are fitted and used in the numerical study. Various FE analyses are performed to investigate pathophysiological situations and surgical treatments using mesh implants to compare their biofunctionality and to optimize the preferred surgery. Hence, the presented models and the modeling approaches included in this thesis facilitate the work of surgeons and urologists by a biomechanical study of female PFDs.},
language = {English},
urldate = {2019-11-01},
school = {Univeristät Duisburg-Essen},
author = {Bhattarai, Aroj},
year = {2019},
doi = {10.17185/duepublico/70340},
note = {ZSCC: NoCitationData[s0] },
}
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Minimally invasive surgery has become a more frequent repair procedure for which more than 20 million implants are implanted worldwide every year. However, serious postoperative mesh relative complications are reported. This thesis reviews the static, functional and dynamic anatomy of the female pelvic floor. A detail methodology to construct a realistic computer model from sheet plastination of a female cadaver pelvic floor has been described. Based on the published literature and multi-disciplinary communication with surgeons and urologist, a most complete form of 3D finite element (FE) model has been constructed, which considers smoothed NURBS based surfaces for frictionless contacts between organs and internal self-contact of the hollow organs. Further, an isotropic, hyperelastic, incompressible multiscale modeling of the soft connective tissues is adopted. In addition, transversely isotropic and non-linear Humphrey's constitutive model has been implemented to describe the passive stretching of the pelvic skeletal muscle without neural excitation. Similarly, for the experimented surgical meshes with different pore characteristics and stress-strain curves, linearly elastic orthotropic and non-linear hyperelastic models are fitted and used in the numerical study. Various FE analyses are performed to investigate pathophysiological situations and surgical treatments using mesh implants to compare their biofunctionality and to optimize the preferred surgery. 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Further, an isotropic, hyperelastic, incompressible multiscale modeling of the soft connective tissues is adopted. In addition, transversely isotropic and non-linear Humphrey's constitutive model has been implemented to describe the passive stretching of the pelvic skeletal muscle without neural excitation. Similarly, for the experimented surgical meshes with different pore characteristics and stress-strain curves, linearly elastic orthotropic and non-linear hyperelastic models are fitted and used in the numerical study. Various FE analyses are performed to investigate pathophysiological situations and surgical treatments using mesh implants to compare their biofunctionality and to optimize the preferred surgery. 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